DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5921 and Lnx1

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001153049.1	Gene:	Lnx1 / 16924	MGIID:	1278335	Length:	728	Species:	Mus musculus

Alignment Length:	327	Identity:	87/327 - (26%)
Similarity:	122/327 - (37%)	Gaps:	80/327 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GFFVSHVEHGGEAHLKG-LRIGDQILRINGFRL-----DDAVHKEFIQLVAGQDRVTLKVRGVGM 156
            |.|:.:|.:||.|...| |...|::|.|||..|     :.|.|  .||  |.:.||.|.|.....
Mouse   409 GVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAH--LIQ--ASERRVHLVVSRQVR 469

  Fly   157 LPVRDLPEERLSWSVVKLPSVSGTPSESSFKGERRGASRDIS------VVLHVAPRTKLGLGICK 215
            ....|:.:| ..|        .....:|...|||..||:..:      |.:...|...||:.:..
Mouse   470 QSSPDIFQE-AGW--------ISNGQQSPGPGERNTASKPAATCHEKVVSVWKDPSESLGMTVGG 525

  Fly   216 GP---EWKPGIFVQFTKDRSV-AREAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSS-----KL 271
            |.   ||...|:|...:...| :|:..::.||.:|:||.|:.::|..:||||::||:.     |.
Mouse   526 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSAPSSVVLKA 590

  Fly   272 DMVVRTAAGCDLFPGE-SSGYNSSASSVT--GDQSPCWA-------------DAKSKRLTAVREE 320
            ..|....|..|..|.. .|.:|     ||  ||.||.|.             |...:|.||
Mouse   591 LEVKEQEAQEDCSPAALDSNHN-----VTPPGDWSPSWVMWLELPQYLCNCKDVILRRNTA---- 646

  Fly   321 SGAGGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINN-------TYIASTGGSSV 378
                 |..|....         .|.|.:.......||....||...|       ..:.:..|.|.
Mouse   647 -----GSLGFCIV---------GGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697

  Fly   379 SG 380
            ||
Mouse   698 SG 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	22/59 (37%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	26/93 (28%)
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..220
		NPXY motif	185..188
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244
		PDZ_signaling	276..360	CDD:238492
		PDZ_signaling	384..464	CDD:238492	22/58 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..500		7/26 (27%)
		PDZ_signaling	506..589	CDD:238492	24/82 (29%)
		PDZ_signaling	637..721	CDD:238492	17/81 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900