DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Il16

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001347016.1	Gene:	Il16 / 16170	MGIID:	1270855	Length:	1424	Species:	Mus musculus

Alignment Length:	931	Identity:	183/931 - (19%)
Similarity:	304/931 - (32%)	Gaps:	273/931 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SASLTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGG 78
            :|..|.|.||.....:.|...:|..|::                                :|:.|
Mouse   289 TARPTRSLSTAQLGQLSGGLQASVISNI--------------------------------VLMKG 321

  Fly    79 PERGSTYGFTVRGGRE--HG-TGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKEFIQ 139
            ..:|  .||::.||::  :| .|.:|..:..||.|...| |:.||:||.:||..:....|::.:|
Mouse   322 QAKG--LGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 384

  Fly   140 LV--AGQDRVTLKVRGVGMLPVRDLPE--ERLSWSVVKLPSVS--GTPSESSFKGERRG-----A 193
            ..  |.:..:||.||.....|    |.  ..||..:.:..|.|  |....|.|..|...     |
Mouse   385 KFKQAKKGLLTLTVRTRLTTP----PSLCSHLSPPLCRSLSSSTCGAQDSSPFSLESPASPASTA 445

  Fly   194 SRDISVVLHVAPRTK----LGLGICKGPEWK--PGIFVQFTKDRSVAREAG-LRPGDQILSVNSI 251
            ..:..:::.|:.:.:    ||:|:|..|.::  .||||......|||...| ||.||:|:.:|..
Mouse   446 KPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEINDS 510

  Fly   252 DFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSASSVTG-----DQSPCWADAKS 311
            ....:..:|...::.......:.:..:...|....|.....:.|.:|.|     |:.. |:....
Mouse   511 PVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVEGVKFGKDRHQ-WSLEGV 574

  Fly   312 KRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINNTYIA-STGG 375
            |||    |.|..|        .|.............|::..|.:::     :|.:::|:: |.||
Mouse   575 KRL----ESSWHG--------RPTLEKEREKHSAPPHRRAQKIMVR-----SSSDSSYMSGSPGG 622

  Fly   376 SSVSG---------SGSTGSGTSGRSQQSQSNPSNPSRNS-------TTMKRSHLRPVNSAGSGI 424
            |..|.         .|||.|.:....::.:..|..|||..       .:::|....|:..
Mouse   623 SPCSAGAEPQPSEREGSTHSPSLSPGEEQEPCPGVPSRPQQESPPLPESLERESHPPLRL----- 682

  Fly   425 GLSSGSAGSAGSAGSSGSGSRSGGVIAPAPA---PPPPAMNEGANASGSVGSSLSSAITEELKKR 486
                               .:|..::...|.   |.||......|.|            |..||.
Mouse   683 -------------------KKSFEILVRKPTSSKPKPPPRKYFKNDS------------EPQKKL 716

  Fly   487 KEKQQQQQHQQRHNRDRDRDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQ------RANVAG---- 541
            :||::.                          ....||.........|:      :.:.||
Mouse   717 EEKEKV--------------------------TDPSGHTLPTCSQETRELLPLLLQEDTAGRAPC 755

  Fly   542 VAATLQG---SERISNLTGGGGAGGAGGSNGAAG------------------AGGDQHTALMDEF 585
            .||...|   |.:.|:.|.|.....|.....|:.                  ...|....:.|..
Mouse   756 TAACCPGPAASTQTSSSTEGESRRSASPETPASPGKHPLLKRQARMDYSFDITAEDPWVRISDCI 820

  Fly   586 KRAHQR-MFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMPTMRPVSM 649
            |..... |..|..|......:|||:                  ::|..|..|| |:  :....:.
Mouse   821 KNLFSPIMSENHSHTPLQPNTSLGE------------------EDGTQGCPEG-GL--SKMDAAN 864

  Fly   650 GRPLVTMSTYQERGETLKR-TSIMPDESCYRNSINSNNNNGFSRNRSNSNTNNNNRLQSQNGVNP 713
            |.|.|..|.   .|.|:|: ..:.|..:.:|.|:....|......|..         :..:.:.|
Mouse   865 GAPRVYKSA---DGSTVKKGPPVAPKPAWFRQSLKGLRNRAPDPRRPP---------EVASAIQP 917

  Fly   714 ANGNGSPELPPPPPQ-----------FANPQPKQMPPQ-----HIKPMTGNAA-----ANGSGSA 757
            ...:..|  |.|.||           |.|....|:|.:     .::|.:|...     .:|...:
Mouse   918 TPVSRDP--PGPQPQASSSIRQRISSFENFGSSQLPDRGVQRLSLQPSSGETTKFPGKQDGGRFS 980

  Fly   758 NGLGNGSLAKVRQPMSPMRSASISV---GGFRPPATPQ--------------PDYDAVQIRSSQG 805
            ..||.|:....:...:.:.|.|.:.   ...|.|..|:              || ..:::.::|
Mouse   981 GLLGQGATVTAKHRQTEVESMSTTFPNSSEVRDPGLPESPPPGQRPSTKALSPD-PLLRLLTTQ- 1043

  Fly   806 SESVSGRDVATSQQQRRTLRL 826
            ||...|..:....|:.|:..|
Mouse  1044 SEDTQGPGLKMPSQRARSFPL 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	24/75 (32%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	21/85 (25%)
Il16	NP_001347016.1	PDZ_signaling	316..391	CDD:238492	24/108 (22%)
		PDZ_signaling	454..536	CDD:238492	21/81 (26%)
		Atrophin-1	<620..931	CDD:331285	71/407 (17%)
		PDZ_signaling	1206..1283	CDD:238492
		PDZ_signaling	1328..1409	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900