DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and FRMPD2

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	417	Identity:	95/417 - (22%)
Similarity:	146/417 - (35%)	Gaps:	134/417 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SLTNS--ASTD-CSSSMQGSTTS-SASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLV 76
            |..||  :||| .|...|||..| :...|..|.....|.....:|   |||       ||...|
Human   874 STANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVP---RLR-------HQLSFL- 927

  Fly    77 GGPERGS--------------------------TYGFTVRGGREHGT---GFFVSHVEHGGEAHL 112
              |.:|:                          |.||:|.||.....   |.:|..:..||.|..
Human   928 --PLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAK 990

  Fly   113 KG-LRIGDQILRINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPS 176
            :| :..||::|:::|..|....||:.:|.:.|..:|           .|.:.|.|:..|..:.||
Human   991 EGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQV-----------ARLVLERRVPRSTQQCPS 1044

  Fly   177 VSGTPSESSFKGERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGI----------FVQFTKDR 231
            .:.:      .|:.|.|   :|:|..:..|....:.:..||:::..:          |||..|:.
Human  1045 ANDS------MGDERTA---VSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKES 1100

  Fly   232 -----------------SVAREAG-LRPGDQILSVNSIDFSDVLFSEAVAVMKSS-SKLDMVVRT 277
                             ..|.|.| :..||.||:||......::|.|.:.:::.: .::.:::
Human  1101 CSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL-- 1163

  Fly   278 AAGCDLFPG------------ESSG--------YNSSASSVTGDQSPCWADAKSKRLTAVREESG 322
               |...||            |.|.        ...|.:|...||...|.|:.|.
Human  1164 ---CRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASP---------- 1215

  Fly   323 AGGGGCGL---SSAPGAGSPNWSQGVE 346
            ..|.|.||   ||........|.|..|
Human  1216 DAGEGLGLRPESSQKAIREAQWGQNRE 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	23/99 (23%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	20/107 (19%)
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302
		B41	346..550	CDD:214604
		FERM_C_PTPH13	546..647	CDD:270008
		PDZ_signaling	773..857	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880		3/5 (60%)
		PDZ	947..1034	CDD:214570	24/97 (25%)
		PDZ	1078..1167	CDD:214570	16/93 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900