DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Patj

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_038965114.1	Gene:	Patj / 140581	RGDID:	1565362	Length:	1858	Species:	Rattus norvegicus

Alignment Length:	976	Identity:	180/976 - (18%)
Similarity:	304/976 - (31%)	Gaps:	320/976 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SSDVMTLTTTAASSWCAIPASSR--------------LRVLRLVRPHQRRLLVGGPERGSTYGFT 88
            ||.|..:::..|::.|.:|....              .|::.:.|           |...:.|.:
  Rat  1037 SSHVGMVSSRHANAACELPEREEGEGEETPNFSHWGPPRIVEIFR-----------EPNVSLGIS 1090

  Fly    89 VRGGR---------EHGTGFFVSHV-EHGGEAHLKGLRIGDQILRINGFRLDDAVHKE------- 136
            :.||:         |...|.|:..| |.......|.|:.||:||.::|..|.:|.|.|
  Rat  1091 IVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTKALKTGDKILEVSGVDLQNASHAEAVEAIKS 1155

  Fly   137 -------FIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSV---------VKLPSVSGTPSESS 185
                   .:|.::...||...|...|..|.::..:.......         :|||.....||..:
  Rat  1156 AGNPVVFVVQSLSSTPRVIPSVNNKGKTPPQNQDQNTQEKKAKRHGTAPPPMKLPPPYRAPSADT 1220

  Fly   186 FKGERRGASRDISV---------VLHV--APRTKLGLGIC---KGPEWKPGIF-VQFTKDRSVAR 235
            .:.|...|..|..:         .||:  ..:.|.|||:.   .....:..|| |....|...|.
  Rat  1221 EESEEDSALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPDGPAAA 1285

  Fly   236 EAGLRPGDQILSVNSIDFSDVLF----SEAVAVMKSSS---KL------DMVVRTAAGCDLFPGE 287
            :..:|.||::|.:|    :.:|:    ..|.|::|::.   ||      |.|.:.|......|..
  Rat  1286 DGRMRVGDELLEIN----NQILYGRSHQNASAIIKTAPTRVKLVFIRNEDAVNQMAVAPFPVPSH 1346

  Fly   288 SSG-----------YNSSASSVTGDQSPCWADAKSKRLT------AVREESGAGGGGCGLSSAPG 335
            |..           .:...|||.....|....:|.:.||      .|.|:..|       |.:|.
  Rat  1347 SPSPVEDLGGTEPVSSEEDSSVDAKPLPERESSKPEDLTQAVDDSMVAEQEKA-------SESPD 1404

  Fly   336 AGSPNWSQGVEVHKQMNKTIIKLTENGTSINNTYIASTGGSS-----------------VSGSGS 383
            :.:          :||.:.             .|.|....||                 |:|||:
  Rat  1405 SAA----------RQMKQP-------------GYSAQVSSSSQEIPSAPAPLCQSTHADVTGSGN 1446

  Fly   384 TGSGTSGRSQQSQSNPS----NPSRNSTTMKRSHLRPVNSAGSGIGLSSGSAGSAGSAGSSGSGS 444
            ..:..|       .:|:    :|:.......:..:..::...||:|||.
  Rat  1447 FQAPLS-------VDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSI---------------- 1488

  Fly   445 RSGGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQ---HQQRHNRDRDRD 506
             .||...|.|                 |.||.:.:....||.:|...|..   |:........||
  Rat  1489 -VGGKDTPLP-----------------GGSLPTKVGVWEKKLQEMMSQDAIVIHEVYEEGAAARD 1535

  Fly   507 GNGNVDRQLTGHNG----NGGHRSSV----------------GQVSHRQRANVAGVAATLQGSER 551
            |......|:...||    :..|..::                .:..:|...|:......||
  Rat  1536 GRLWAGDQILEVNGVDLRSSSHEEAITALRQTPQKVRLVIYRDEAQYRDEENLEVFLVDLQ---- 1596

  Fly   552 ISNLTGGG-GAGGAGGSNGAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADR 615
              ..||.| |....|                    ||:...:|          :|.:.|...||
  Rat  1597 --KKTGRGLGLSIVG--------------------KRSGSGVF----------ISDIVKGGAAD- 1628

  Fly   616 SLYGREMSLLRVKNGGSGGGEGSGVMPTMRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRN 680
             |.||   |:|.....|..||      .:|..|           ||...|:.:        |.:.
  Rat  1629 -LDGR---LIRGDQILSVNGE------DVRQAS-----------QETVATILK--------CVQG 1664

  Fly   681 ----SINSNNNNGFSRNRSNSNTNNNNRLQSQNGVNPA---------NGNGSPELPPPPPQFANP 732
                .|.......::.:|..|..:..::..:.:...|:         |..|:.....||.:....
  Rat  1665 LVQLEIGRLRAGSWASSRKTSQNSQGDQHSAHSSCRPSFAPVITSLQNLVGTKRSSDPPQKCTEE 1729

  Fly   733 QPKQMP-PQHIKPMTGNAAANGSGSANG---------LGNGSLAKVRQPMSPMRSASISVGGFRP 787
            :|:.:. .:.:....|.:.|.|.||..|         ..||..|:.::  ..:....:|:.|  .
  Rat  1730 EPRTVEIIRELSDALGVSIAGGKGSPLGDIPIFIAMIQANGVAARTQK--LKVGDRIVSING--Q 1790

  Fly   788 PATPQPDYDAVQ-IRSSQGS---ESVSGRDVATSQQQRRTLRLGTVTIGEYGDQRTTGKRETLRK 848
            |.......|||. ::::.|.   :.|:..:::....|...:..|:.......|:......|.|::
  Rat  1791 PLDGLSHTDAVNLLKNAFGRIILQVVADTNISAIATQLEMMSAGSQLGSPTADRHPQDPEELLQR 1855

  Fly   849 T 849
            |
  Rat  1856 T 1856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	22/93 (24%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	24/106 (23%)
Patj	XP_038965114.1	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492
		PDZ_signaling	366..450	CDD:238492
		CtpA	<391..>511	CDD:223864
		PDZ_signaling	572..636	CDD:238492
		PDZ	684..773	CDD:214570
		PDZ_signaling	1074..1165	CDD:238492	22/101 (22%)
		PDZ	1244..1329	CDD:214570	22/88 (25%)
		PDZ	1471..1578	CDD:214570	24/140 (17%)
		PDZ_signaling	1590..1670	CDD:238492	28/145 (19%)
		PDZ_signaling	1731..1816	CDD:238492	17/88 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810