DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and whrnb

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_005172005.1	Gene:	whrnb / 100534775	ZFINID:	ZDB-GENE-060526-377	Length:	946	Species:	Danio rerio

Alignment Length:	933	Identity:	195/933 - (20%)
Similarity:	315/933 - (33%)	Gaps:	254/933 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SASLTNSASTDCSSSMQGSTTSSA----SSD-------------VMTLTTTAASSWCAIPASSRL 61
            :||:.:..|.|.||:...:..||.    .||             |.:.:....:....:.|.|.:
Zfish   111 AASVKHECSEDLSSTNAHAGASSVHFAPQSDQAGPSHGSLRPASVFSTSAEGTAPALMLEAPSEI 175

  Fly    62 RVLRLVRPHQRRLLVGGPERGSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQILRING 126
            |.:.|.|......|          ||::|||.|||.|.:||.||.|..|..:|||:||||:::|.
Zfish   176 RQVTLKRSKSHEGL----------GFSIRGGSEHGVGIYVSLVEPGSSAEREGLRVGDQIMKVNN 230

  Fly   127 FRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPS--ESSFKGE 189
            ...|...|.|.::::.|..::::.|..:|.:|...:.....:|...:..|||..|.  |....|.
Zfish   231 VVFDRVTHGEAVKVLKGSKKLSMSVCSMGRIPGGYVTNHVYTWVDPQGRSVSPPPDLVEQHSLGG 295

  Fly   190 RRG---ASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQILSVNSI 251
            |..   .:.:..|.:.:.....|||.|..|.|:..||::......|.|..:||:.|||||.||..
Zfish   296 RLSDLHTNTEKKVNISLDDGRSLGLMIRGGAEYALGIYITGVDRGSAAEYSGLKVGDQILEVNGR 360

  Fly   252 DFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSASSVTGDQSPCW---------- 306
            :|..:...|||.::|:|..:.|.::..           |....|.:|..:..  |
Zfish   361 NFRSICHDEAVQILKNSRHMLMTIKDV-----------GRLPHARTVVDETK--WIPSAQIAESS 412

  Fly   307 ADAKSKRLTAVREESGA-GGGGCGLSSAPGAGSPN---WSQGVEVHKQMNKTIIKLTENGTSINN 367
            |::.|:.:.:|...:|: |...|.....|..|:..   ||...|      :..:.|||......:
Zfish   413 ANSNSQSILSVDVGTGSLGKSVCCKGVVPAVGAVRAGAWSSLEE------QAFMLLTETERQTMS 471

  Fly   368 TYI-----ASTGGSSVSGSGSTGSGTSGR-----SQQSQSNPSNPSR--NSTTMKRSHLRPVNSA 420
            .||     |..|...::.:......|..:     ..::...|.:..|  ....::..........
Zfish   472 YYIQEYQRAHIGVEPLAMALFELFNTHAKLSLLAEVRTLVAPQDLERFDGQVLLREMEAWRARHG 536

  Fly   421 GSGI------------GL--SSGSAGSAGSAGSSGSGSRSGGVIAPAPA---------------- 455
            |.|:            ||  |.....:.|.:|.|.|..|..|.:.|...
Zfish   537 GQGLLHPDSICITQPEGLVPSPACQMNTGGSGYSKSECRLDGSLMPLETLNSLPDVALDKVQVSS 601

  Fly   456 -------PPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQ---------QQHQQRHNRDRD 504
                   ||||.:...:..:             :.|:...|..|         ::||:.|..:..
Zfish   602 ESPPSFKPPPPPIRHASPKT-------------QTKRPSSKLSQTNLFFTAPFRRHQENHTLNHS 653

  Fly   505 RDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNG 569
            .....:.....|.|     |.:|...:||     .....:....|.|.|:.            :.
Zfish   654 HLSCSSHTSPCTIH-----HTTSPCSISH-----TPPPCSHHHSSPRTSSY------------HS 696

  Fly   570 AAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGG 634
            :..:|.|     :.:|....|....:...||.:: |..|...::.||......|||
Zfish   697 SPSSGRD-----LVQFLMNRQAGTLSPHPESPNR-SRDGTPMISPRSSPSLSPSLL--------- 746

  Fly   635 GEGSGVMPTMRPVSMGRPLVTMSTY------------------QERGETLKRTSIMPDESCYRNS 681
                  ||...|.|..|...:.||:                  |.||.||.:.|
Zfish   747 ------MPAPPPCSPERLDGSPSTHSCGPQHAEPETTEDRPQPQLRGATLSQLS----------- 794

  Fly   682 INSNNNNGFSRNRSNSNTNNNNRLQSQNGVNPANGNGSPELPPPPPQFANPQPKQMPPQHIKPMT 746
                              ::...|...:||:.|...|.       .:.::|:|.:.|.|.....|
Zfish   795 ------------------DSGQTLSEDSGVDIAEAGGL-------SKDSSPRPGKPPFQQFTGDT 834

  Fly   747 GNAAANGSGSANGLGNGSLAKVRQPMSPMRSAS---ISVGGFRPPATPQPDYDAVQIRSSQGSES 808
            ..|......:|..:|......||.|    :.||   |:|.|......|.|....:|   ..||..
Zfish   835 RRAEGLAQATAKQMGMMEPILVRVP----KCASTLGIAVEGGANTRQPLPRIATIQ---KGGSVH 892

  Fly   809 VSGRDVATSQQQRRTLRLGTVTI 831
            :.|:           ||:|.|.:
Zfish   893 LCGQ-----------LRVGQVIL 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	27/69 (39%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	27/78 (35%)
whrnb	XP_005172005.1	HN_L-whirlin_R1_like	24..101	CDD:259822
		PDZ_signaling	175..256	CDD:238492	31/90 (34%)
		PDZ_signaling	305..385	CDD:238492	27/79 (34%)
		HN_L-whirlin_R2_like	454..527	CDD:259823	11/78 (14%)
		PDZ_signaling	853..939	CDD:238492	18/70 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920