DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and pdzd7a

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001177686.1	Gene:	pdzd7a / 100332580	ZFINID:	ZDB-GENE-090313-191	Length:	954	Species:	Danio rerio

Alignment Length:	1017	Identity:	209/1017 - (20%)
Similarity:	337/1017 - (33%)	Gaps:	351/1017 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASASISTSASLTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIP-----ASSRLRVLRL 66
            |.:|.:....:||.|.........|::|                    :|     ...|.|.:|.
Zfish     2 AHSSDTARKDMTNGAHPSAQPGPSGTST--------------------LPRYLHKKQQRQRGVRS 46

  Fly    67 VRPHQRRLLVGGPERGST-----------------YGFTVRGGREHGTGFFVSHVEHGGEAHLKG 114
            ..|..|.:|:..|..|..                 .||:||||.|||.|.|||.||....|.:.|
Zfish    47 SSPMGRVILINAPVDGGDDSEDIHTITVDKSEDGHLGFSVRGGSEHGLGIFVSKVEDDSTAEMAG 111

  Fly   115 LRIGDQILRINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSW-------SVV 172
            |.:||:::.:||..|:.......::::.|.:|:.:.||.||.:|.....:|:.:|       .||
Zfish   112 LCVGDKLVEVNGISLESITMSSAVKVLTGNNRLRMVVRRVGKVPGIRYSKEKTTWVDLIHRRMVV 176

  Fly   173 KLPSVSG-TPSESSFKGERRGASRDISVVLHVAPRTK---LGLGICKGPEWKPGIFVQFTKDRSV 233
            :   .|| ||||:|..|..|.       ::|:...:.   ||..|..|.|:..||:|.......:
Zfish   177 E---ESGRTPSEASSDGALRR-------IVHLYTTSDDYCLGFNIRGGKEFGLGIYVSKLDPGGL 231

  Fly   234 AREAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSASSV 298
            |.:.|::.|||||:.|.:.|.|:..|.||.|:||.:.:.:.::.|       |....|....:..
Zfish   232 AEQNGIKMGDQILAANGVSFEDITHSNAVEVLKSHTHVMLTIKEA-------GRYPAYKEMVAEY 289

  Fly   299 TGDQSPCWADAKSKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGT 363
            :      |                       |:.....|.|:.|||.:.:...:.     ..:||
Zfish   290 S------W-----------------------LNKLANGGQPSSSQGSDSYSSTSS-----LSSGT 320

  Fly   364 SINNTYIASTGGSSVSGSGSTGS-------GTSGRSQQS---------QSNPSNP---SRNSTTM 409
            .:::.    :|.|.|:...:.||       .|..||::.         |::|.:|   ||.|..|
Zfish   321 PVSSL----SGLSQVTFPPAFGSEMVDVCISTEDRSRRPSSERIETAIQTDPQDPDTISRTSRVM 381

  Fly   410 KRSHLRPVNSAGSGIGLSS-----GSAGS---AGSAGSSGSGSRSGGVIAPAPAPPPPAMNEGAN 466
            .....|.|   |..:.|..     |:|.|   ..|||...:.......:..|.:.|..|:....:
Zfish   382 STETSRMV---GETVLLKDTVIRRGTAHSRTRTFSAGDKETLDSPKTAVLMALSKPRKAIRRSQS 443

  Fly   467 -------------ASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVDRQLTGH 518
                         ||...|.:..|       ::::||::::||:           |.|:.:
Zfish   444 HITVSEFWFATERASCLCGCTSRS-------RQEDKQKKRKHQK-----------GKVETE---- 486

  Fly   519 NGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAGGDQHTALMD 583
                                    .:|||.|:....|
Zfish   487 ------------------------GSTLQRSKTFVTL---------------------------- 499

  Fly   584 EFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMPTMRPVS 648
            .||...:|                .:||..||...|||       :|..|..:....:.......
Zfish   500 PFKSGRRR----------------ERSSSRDRKDTGRE-------DGHKGRSKSPKHLDNEPGKE 541

  Fly   649 MGRPLVT-MSTYQERGETLKRTSIMPD-------ESCYRNSINSNNNNGFSRNRSN--------- 696
            .|||::. :|:.:|....|:..|.||.       |...|..:|.:......|:...
Zfish   542 RGRPIINLLSSPRETRAGLREQSPMPSPETMALLEDVARKLLNEDEVAAVMRHCKRFLVDRVVED 606

  Fly   697 ---------SNTNNNNRLQSQNGVNPANGNG-----------------------SPELPPP---- 725
                     ........|:....:.||...|                       ||.|..|
Zfish   607 LVRPLLAILDKPEKLLLLREVRMIIPATDLGRFDSMVLPFELEAYDILKSRSVRSPVLRSPRHGG 671

  Fly   726 PPQ--FANPQPKQMPPQHIKPMTGNAAANGSGSANGLGNGSLAKVRQ---PMSPMRSASISVGGF 785
            .|:  ...|.|......|::|:.                 .|.:.||   .:..||.|.:..|..
Zfish   672 TPRRHLITPIPDYRGGFHLQPVQ-----------------DLERERQLIEDLERMRLAGLPTGRL 719

  Fly   786 RPPA--TPQPD-----YDAVQIRSSQGSESVSGRDVATSQQQRRTLRLGTVTIGEYGDQRTTGKR 843
            .||.  ||..|     |....:|:...|.:.||...:.|               .|..:||  .|
Zfish   720 PPPRAFTPLLDVPVDTYITDSLRNRSLSPARSGFSHSES---------------PYSTERT--GR 767

  Fly   844 ETLRKTNGEPASNGILKNGSN---RSSASFNHGSSHQTEKTI 882
            ..||:.||.| .:.:...|.:   |..:.:.:|...:|:|::
Zfish   768 SPLRRDNGFP-HDSLSSRGDSVPERGRSPYRNGHRMKTDKSL 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	26/86 (30%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	25/81 (31%)
pdzd7a	NP_001177686.1	PDZ_signaling	69..149	CDD:238492	25/79 (32%)
		PDZ_signaling	194..274	CDD:238492	25/86 (29%)
		HN_PDZD7_like	568..645	CDD:259824	8/76 (11%)
		PDZ_signaling	860..948	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920