Protein Alignment CG5921 and ush1c

DIOPT Version :10

• Sequence 1: NP_727061.2
• Gene: CG5921 / 31538
• FlyBaseID: FBgn0029835
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: XP_031755612.1
• Gene: ush1c / 100125158
• XenbaseID: XB-GENE-1018491
• Length: 930
• Species: Xenopus tropicalis
• Alignment Length: 816
• Identity: 176/816 - (21%)
• Similarity: 258/816 - (31%)
• Gaps: 276/816 - (33%)

  Fly    58 SSRLRVLRLVRPHQRRLLVGGPERGSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQIL 122
            |.:||.::|.|.|...|           |.::|||.|...|.|:||:...|:|...||:|||:::
 Frog    82 SRKLREVKLDRTHPDGL-----------GLSMRGGLEFNCGLFISHIMKEGQADNTGLQIGDELV 135

  Fly   123 RINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPSESSFK 187
            |||||.:....|:|.|.|:..:..|::|||.|||:||:...:|.|.|.............:||..
 Frog   136 RINGFSIASCTHEEVINLIRTKKIVSIKVRHVGMIPVKSREDEPLKWQYSDQFVSESADGKSSVA 200

  Fly   188 GERRGASRDI---SVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQILSVN 249
            |......|::   .|.:.:...|.:|..|..||..|||||:...|..|::.|.||..||||:.||
 Frog   201 GLASAGGREMKEKKVFISLVGTTGMGCSISSGPSQKPGIFISNVKPGSLSAEVGLEVGDQIVEVN 265

  Fly   250 SIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSASSVTGDQSPCWADAKSKRL 314
            ..||:::...:||.|:|.|..|.:.|...||.:||..|..............|..    .:.|:|
 Frog   266 GEDFTNLDHKQAVKVLKGSRSLTITVVAGAGRELFMTEDERLTEQRRRELERQEL----LRQKKL 326

  Fly   315 T-----AVREESGAGGGGCGLSSAPGAGSPNWSQGV-EVHKQMNKTIIKLTENGTSINNTYIAST 373
            .     .|:|:          ...........||.| |...:..:.|.|::.....|...:....
 Frog   327 AMETNKIVKEQ----------QEKERMRKMEISQKVAEEEDRFRREIEKISSQEEKIKKDWDEDW 381

  Fly   374 GGSSVSGSGSTGSGTSGRSQQSQSNPSNPSRNSTTMKRSHLRPVNSAGSGIGLSSGSAGSAGSAG 438
            |....:.|.......:.||..::|.|
 Frog   382 GPKEEAKSVKPPGAKTQRSPPAKSKP--------------------------------------- 407

  Fly   439 SSGSGSRSGGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDR 503
             .|...|..|..       |....:|.:..    .|.|.::.|:.|.:||.:.:|:..|......
 Frog   408 -FGWFYRYEGKF-------PTLRKKGKDRK----KSKSDSLFEQKKSKKEMEFEQKLAQEKEEML 460

  Fly   504 DRDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERI---------------- 552
            :::....::|             .|.:||..:|.:       |:.||::
 Frog   461 EKEKQLKINR-------------LVQEVSETERED-------LEESEKVQVWVERLCQTRLEQIS 505

  Fly   553 ----SNLTGGGGAGGAGGSNGAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLA 613
                .|...|||...|..|...........|          .|.|..|.|
 Frog   506 SAENENHEVGGGHPPAPPSPPPTAQPPSSST----------MRRFVGGLH--------------- 545

  Fly   614 DRSLYGREMSLLRVKNGGSGGGEGSGVMPT-----MRPVSMGRPLVTMSTYQERGETLKRTSIMP 673
                                       :||     :..|...||...|:........|..:|..|
 Frog   546 ---------------------------LPTTDLDEVHSVETSRPTKRMAPPPPSPRLLSASSHQP 583

  Fly   674 DESCYRNSINSNNNNGFSRNRSNSNTNNNNRLQSQNGVNPANGNGSPELPPPPP----------- 727
                      |:.|..|.|..:                           |||||
 Frog   584 ----------SSPNITFIRRNA---------------------------PPPPPVAPRSSLIQPT 611

  Fly   728 --QFANPQPKQMPPQHIKPMTGNAAANGSGSA-----------NGLGNGSLAKVRQ----PMSP- 774
              ...:|.|..:|          |.|...|||           |..|..:|.....    |.||
 Frog   612 WMHLPSPSPPPVP----------APAQSMGSARPPLPFSEELKNYRGRSALRSSNPEPSFPPSPK 666

  Fly   775 ----------MRSASISVGGFRP-------PATPQP 793
                      |.|:||.: .|.|       ||.|.|
 Frog   667 VVRNVSDASKMSSSSIPL-QFAPSPPTQRRPAVPIP 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ1_harmonin	72..155	CDD:467219	30/82 (37%)
		PDZ_canonical	195..276	CDD:483948	31/83 (37%)
ush1c	XP_031755612.1	harmonin_N	2..80	CDD:259819
		PDZ1_harmonin	84..168	CDD:467219	35/94 (37%)
		PDZ2_harmonin	211..292	CDD:467220	30/80 (38%)
		SMC_N	297..>487	CDD:481474	40/274 (15%)
		CCDC66	<314..>391	CDD:434558	14/90 (16%)
		PDZ3_harmonin	768..860	CDD:467221