Protein Alignment CG5937 and GEA1

DIOPT Version :9

• Sequence 1: NP_001096888.2
• Gene: CG5937 / 31537
• FlyBaseID: FBgn0029834
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_012565.1
• Gene: GEA1 / 853488
• SGDID: S000003792
• Length: 1408
• Species: Saccharomyces cerevisiae
• Alignment Length: 1620
• Identity: 297/1620 - (18%)
• Similarity: 515/1620 - (31%)
• Gaps: 561/1620 - (34%)

  Fly   229 NHSSLYLTECILTLSSALPRNVHANPHFTSFLWQKFCPTLAAALGSPGRINLDKKFTYKDALHMI 293
            |.:::.:.||| .|.||:.:...          .|...::||.||....|.|.:..::.|:.|.:
Yeast    13 NPATMIVKECI-NLCSAMNKQSR----------DKSQTSVAALLGGGSDIFLSQSDSFVDSFHNL 66

  Fly   294 ENEARGFFTGP----------------GLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEAL---- 338
            ...:   :..|                |||.       |.|::|         |:|.||.:
Yeast    67 PTSS---YHDPLISGLVQLRLKINDLKGLDS-------LNALEL---------LKPFLEIVSASS 112

  Fly   339 ---FHRMLLLPAPQNRTEPLRCVREIFKSPERLIDLAVILYVDKNTAQGCSDEMALFRLLVDAME 400
               :...|.|.:.| :...|:.:.:.|..    |.:||                   |..|.|:.
Yeast   113 VSGYTTSLALDSLQ-KVFTLKIINKTFND----IQIAV-------------------RETVVALT 153

  Fly   401 ECAYGASGGGSATEASLQASVEC----MVALLDSLQVLCSGE-LTESMISDQIVQVVN-----GR 455
            .|.:         |||.|.|.:.    :|.||..:.....|: |::::|.|.:...::     .|
Yeast   154 HCRF---------EASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTLSLACNTQR 209

  Fly   456 HDLL-KDADYS-GPLT---YQSMARLPAPYRDAIVEFRQTVFETSSGSESEGEPQHEQDAASNGS 515
            .::| |.|:.: ..:|   :..:..|..|          |..|.....||..:...:.|.....:
Yeast   210 SEVLRKTAEVTIAGITVKLFTKLKLLDPP----------TKTEKYINDESYTDNNLKDDIIGTTT 264

  Fly   516 GDTEGPEDDDPSSSSDETSRVENRWPYSHLEAPVMPIRTDSDNDRQHAR-------DFARALRQD 573
            .|.:....||.|:.:|:...          |.||..:..:.:||.:.|.       ::...:.:|
Yeast   265 SDNDLSSTDDDSAVADDNKN----------EKPVQQVIREQENDEETAEKAENVEPNYGITVIKD 319

  Fly   574 LVPKLLRLRSCVELDEAMQEFASAVCQENSMNF--SDFDYNLTAINA------------------ 618
            .:..||                |.|..||.|..  |....:|..|||
Yeast   320 YLGLLL----------------SLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSL 368

  Fly   619 --DGIYLAI---------YSSLLLSLQLMRA-----GFY---------EQVAQGMSHKDILVPMS 658
              |.|:.::         ||.|..:|||..:     |.|         .::.:.:....|...:|
Yeast   369 ISDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVS 433

  Fly   659 EQQFVTSVQNTGVLVYLSSPWL--------------CELYQSVTVCNVLEAMPRQQLEGMGPRCA 709
            :|: ..:::.. ::..||..|:              |.|.:|....:.::.:.:..|    |..|
Yeast   434 KQK-PPAIREL-IIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSL----PAAA 492

  Fly   710 L-----VDMLCDAGGLGATQ-MLSEWQRLQTAN-VKHKEEEQLHDKR-------------REAAK 754
            :     :..:|..|.|...: :.::.||...|. ||:::|..:..:|             .|.||
Yeast   493 VNTSNNIPPICLEGVLSLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCVETFNEKAK 557

  Fly   755 KLCRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVA---------LSKRT---LRVKAKANKSNG 807
            |           .:.:::..|..|    |.||:.:|         |:|:|   |....|......
Yeast   558 K-----------GIQMLIEKGFID----SDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLK 607

  Fly   808 EALYAMCLDGLHSAATLSNSLNLQHLAGKILNLLASNVCQTSGPRISASQAMSMDVV----LTGG 868
            |.:......||.....:...|....|.|:...:  ..:.:....:.||.|  |.|.|    ...|
Yeast   608 EFIDLFDFKGLRVDEAIRILLTKFRLPGESQQI--ERIVEAFSSKYSADQ--SNDKVELEDKKAG 668

  Fly   869 LNLGSYS------------ADCWPSIFAVCRHVSQLEHEIFSMQNPAISASPGSSRRDLETGEKL 921
            .| ||.|            ||   |:|.:...:..|..:   ..||.:        :|..|.:..
Yeast   669 KN-GSESMTEDDIIHVQPDAD---SVFVLSYSIIMLNTD---SHNPQV--------KDHMTFDDY 718

  Fly   922 SNG-----NAQD-----------KLNLSSIPIDDDE---------------TCVDVYSFLQAPMQ 955
            ||.     |.:|           .:.:..|.:.::.               :...|.:.:|....
Yeast   719 SNNLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQRDFT 783

  Fly   956 SPNTNITSI------LKVYSGTNETVLLSQSDTSKVLCALSHQAENLFGDAAERLSLP-----SL 1009
            :|.:.:..|      ..::|...:.:|       |.|..:...|      :::::||.     |.
Yeast   784 NPISKLAQIDILQYEKAIFSNVRDIIL-------KTLFKIFTVA------SSDQISLRILDAISK 835

  Fly  1010 CQFLKHLCRASRDQLYKSQVARKGSRIWWPSKGWK----KLDSLPMSLLLHRIGDVTLKVFRSSR 1070
            |.|:.:.  .|.||.|...|...|..........|    .:||:|:..:.  :.|...|:..|::
Yeast   836 CTFINYY--FSFDQSYNDTVLHLGEMTTLAQSSAKAVELDVDSIPLVEIF--VEDTGSKISVSNQ 896

  Fly  1071 PL-------------LHVLKVWAITGPHLMDAACHRDRMISKRAIEYIHDIITAL---LVEQSEL 1119
            .:             |:...:..|:.|.:          :|.|....|..:|..|   |:.:..|
Yeast   897 SIRLGQNFKAQLCTVLYFQIIKEISDPSI----------VSTRLWNQIVQLILKLFENLLMEPNL 951

  Fly  1120 PYFHFNEALLKPFENLLSMDTDVDVQDQIVACLYEVVEAHRTEIRSGWRPLFGTLRNARSRMLNM 1184
            |:|....:||| ...|...|.|:.:                                   |...|
Yeast   952 PFFTNFHSLLK-LPELPLPDPDISI-----------------------------------RKAKM 980

  Fly  1185 S-NIIDIFRVFL-----DSDNTLVFANAGLDCILC---LLSYLEISGGGNNNACSGG------SG 1234
            | :::..|..:|     .|:..:.|:....:|:..   |.|..|     ||...|..      |.
Yeast   981 SRSLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFE-----NNQLVSPKMIETLLSS 1040

  Fly  1235 SAAGGTASNGGQQEEDNTFRPTDFLHETLRFLERCSSILGFMHSMPKCPNFHSTYKIKGISYTHI 1299
            .....|:.|            :.:..:.|.||...|.||                 |...||...
Yeast  1041 LVIEKTSEN------------SPYFEQELLFLLEISIIL-----------------ISEASYGQE 1076

  Fly  1300 IDANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHIDKDTIVKIDEMDKPSGVLKVWFLLLDGLT 1364
            ..|.|...|.|.:..  |.|.......:.||:        :..:...|.|..:|
Yeast  1077 FGALIADHMINISNL--DGLSKEAIARLASYK--------MFLVSRFDNPRDIL----------- 1120

  Fly  1365 NSLIVCPYSHQAPILQTIF--KLFKNLLASPGIDFGFYCINHLLVPMIQDWLRYIN---KTGSSW 1424
            :.||    .|...:...||  |.:::       ::|...||.|...:  :.::|..   |....|
Yeast  1121 SDLI----EHDFLVKNEIFNTKYYES-------EWGKQVINDLFTHL--NDVKYNERALKNVKFW 1172

  Fly  1425 QLVEKNFKHCCCMTTD---LVVEFIEKSVPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTE-- 1484
                 ||........|   .|..|:||.:....             :...|....:.|..:.|
Yeast  1173 -----NFLRILISAKDRQFAVYTFLEKYIQNGD-------------IFVDDGNFMNILSLLDEMS 1219

  Fly  1485 ---RIEREQQQQQSPSVQDHGC------GYTQQYDSSSSS-------------ASEEQQKNG--G 1525
               .:..:.:|....||:| ||      .|....|.||.|             ::....||.  .
Yeast  1220 CAGAVGTKWEQNYENSVED-GCEAPESNPYRSIIDLSSRSINITADLLSTVGRSNSALNKNEIIA 1283

  Fly  1526 GVGGGGSNLIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKHVILSTGML 1585
            .:.|.....:....::...|..||:.:||     :..||....:::|..|    |.||:|
Yeast  1284 AIQGLAHQCLNPCDELGMQALQALENILL-----SRASQLRTEKVAVDNL----LETGLL 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	55/316 (17%)
		DUF1981	1115..>1179	CDD:286414	9/63 (14%)
GEA1	NP_012565.1	COG5307	283..1325	CDD:227623	223/1262 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030