DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5937 and ARFGEF3

DIOPT Version :9

Sequence 1:	NP_001096888.2	Gene:	CG5937 / 31537	FlyBaseID:	FBgn0029834	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	NP_065073.3	Gene:	ARFGEF3 / 57221	HGNCID:	21213	Length:	2177	Species:	Homo sapiens

Alignment Length:	2401	Identity:	602/2401 - (25%)
Similarity:	991/2401 - (41%)	Gaps:	620/2401 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDLFLLIIKESTGTKHNALRQTAQIAYDKLYRQHGIHRDPSHELRSVCFTALQMALDTKRPKFI 65
            ||::...:.||::|:|:.|::::...|.:.|.....|.:.|.|.||..|...||:||::|..|..
Human     1 MEEILRKLQKEASGSKYKAIKESCTWALETLGGLDTIVKIPPHVLREKCLLPLQLALESKNVKLA 65

  Fly    66 TMGLNGLHRVIKDERFYIGLEPEDDSVWLPSQLLRATNGILPTTSSEDTVVNVLRLFLAMACSPA 130
            ...|.|:.:::.:||| :.:|.:.|...|.:|:|.|.. :.|:. :||..|.|:::.|.:..:|.
Human    66 QHALAGMQKLLSEERF-VSMETDSDEKQLLNQILNAVK-VTPSL-NEDLQVEVMKVLLCITYTPT 127

  Fly   131 CTLNGRLLIEILSRCGECW--EMGSRATKAASLAAASQCLRTFCAFLIEEAEEV---KKTAPAGL 190
            ..|||..:::|...|.|.:  ....|:...|..|..||.|......|.:..|..   ....|...
Human   128 FDLNGSAVLKIAEVCIETYISSCHQRSINTAVRATLSQMLSDLTLQLRQRQENTIIENPDVPQDF 192

  Fly   191 MTQ-TQASAVYNEVIPVMQWLCSRLVEPNVNASPNKKCENHSSLYLTECILTLSSALPRNVHANP 254
            ..| :...::.::|:.|:..||.:| :..:|.|     :....||| ||||::.|:...::|.:.
Human   193 GNQGSTVESLCDDVVSVLTVLCEKL-QAAINDS-----QQLQLLYL-ECILSVLSSSSSSMHLHR 250

  Fly   255 HFTSFLWQKFCPTLAAALGSPGRINLDKKFTYKDALHM---------------IENEARG---FF 301
            .||..:|:..||.|...||:|..   ||..|   :.|.               :.:..||   ..
Human   251 RFTDLIWKNLCPALIVILGNPIH---DKTIT---SAHTSSTSTSLESDSASPGVSDHGRGSGCSC 309

  Fly   302 TGPGLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCVREIFKSPE 366
            |.|.|.||.||.:|..|.:|:|:.|:..|::|:|::|:||:||.|.||:|.|.::.::||..||:
Human   310 TAPALSGPVARTIYYIAAELVRLVGSVDSMKPVLQSLYHRVLLYPPPQHRVEAIKIMKEILGSPQ 374

  Fly   367 RLIDLAVILYVD----KNTAQGCSDEMALFRLLVDAMEECAYGASGGGSATEASLQASVECMVAL 427
            ||.|||.....:    |.:.......:.|.:|::|.|.|..  ..||..|    ..|:|.|:..|
Human   375 RLCDLAGPSSTESESRKRSISKRKSHLDLLKLIMDGMTEAC--IKGGIEA----CYAAVSCVCTL 433

  Fly   428 LDSLQVLCSGELTESMISDQIVQVVNGRHDLLKDA------------------------------ 462
            |.:|..|..|:    .:|:..||::..|.:.|||.
Human   434 LGALDELSQGK----GLSEGQVQLLLLRLEELKDGAEWSRDSMEINEADFRWQRRVLSSEHTPWE 494

  Fly   463 --------------------------------DYSGPLTYQSMARLPA----------------- 478
                                            |:||  .:::..:.||
Human   495 SGNERSLDISISVTTDTGQTTLEGELGQTTPEDHSG--NHKNSLKSPAIPEGKETLSKVLETEAV 557

  Fly   479 ------------PYRDAIVEFRQTVFETSSGSESEGEPQHEQD-----------------AASNG 514
                        ||.| |..|......|.|......|.....|                 ||...
Human   558 DQPDVVQRSHTVPYPD-ITNFLSVDCRTRSYGSRYSESNFSVDDQDLSRTEFDSCDQYSMAAEKD 621

  Fly   515 SGDTEGPE-DDDPSSSSDETSRVENRWPYSHLEAPVMPIR--TDSDNDRQHARDFARALRQDLVP 576
            ||.::..: ..|..|.:||.....:...:..|....:.::  .:.:.|:..||.|.::| :.|:|
Human   622 SGRSDVSDIGSDNCSLADEEQTPRDCLGHRSLRTAALSLKLLKNQEADQHSARLFIQSL-EGLLP 685

  Fly   577 KLLRLRSCVELDEAMQEFASAVCQENSMNFSDFDYNLT-----AINADGIYLAIYSSLLLSLQLM 636
            :||.|.:..|:|.|:|.|||..| ...|:...||.|.:     .:|||.:|.|.:.:|||:|:|.
Human   686 RLLSLSNVEEVDTALQNFASTFC-SGMMHSPGFDGNSSLSFQMLMNADSLYTAAHCALLLNLKLS 749

  Fly   637 RAGFYEQVAQGMSHKDILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQSVTVCNVL-------- 693
            ...:|.:       :..|.|...:.|:..||.:|||:..|..|:.|||..|...|:|
Human   750 HGDYYRK-------RPTLAPGVMKDFMKQVQTSGVLMVFSQAWIEELYHQVLDRNMLGEAGYWGS 807

  Fly   694 ---EAMPRQQLEGMGPRCALVDMLCDAGGLGATQMLSEWQRLQTANVKHKEEEQLHDKRREAAKK 755
               .::|            |:.||.|..||.::.:..:............:..::.|. ..|...
Human   808 PEDNSLP------------LITMLTDIDGLESSAIGGQLMASAATESPFAQSRRIDDS-TVAGVA 859

  Fly   756 LCRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYAMCLDGLHS 820
            ..|.:|..||.:::..||:.|......|:......|....::   :.|:...:|: .|.||||..
Human   860 FARYILVGCWKNLIDTLSTPLTGRMAGSSKGLAFILGAEGIK---EQNQKERDAI-CMSLDGLRK 920

  Fly   821 AATLSNSLNLQHLAGKILNLLASNVC--------------------------------QTSGPRI 853
            ||.||.:|.:.......|..:|:..|                                :..|..:
Human   921 AARLSCALGVAANCASALAQMAAASCVQEEKEEREAQEPSDAITQVKLKVEQKLEQIGKVQGVWL 985

  Fly   854 SASQAMSMDVVLTGGLNLGSYSADCWPSIFAVCRHVSQLEHEIFS---MQNPAISASPGSSRRDL 915
            ..:..:.|:.:|:.||.:||::.||||.:|.||.:|..|||..||   .|.|...:.|..:
Human   986 HTAHVLCMEAILSVGLEMGSHNPDCWPHVFRVCEYVGTLEHNHFSDGASQPPLTISQPQKA---- 1046

  Fly   916 ETGEKLSNGNAQDKLNLSSIPIDDDETCVDVYSFLQAPMQSPNTNITSILKVYSGTNET-----V 975
             ||   |.|...|.....|.|....|   ...|...||:..| .:|..:::..|....:     .
Human  1047 -TG---SAGLLGDPECEGSPPEHSPE---QGRSLSTAPVVQP-LSIQDLVREGSRGRASDFRGGS 1103

  Fly   976 LLSQSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIWWPS 1040
            |:|.|..:||:..||.||:.||.||.::|:|.:|..||..|.:||:.||:.|........:..|.
Human  1104 LMSGSSAAKVVLTLSTQADRLFEDATDKLNLMALGGFLYQLKKASQSQLFHSVTDTVDYSLAMPG 1168

  Fly  1041 KGWKKLDSLPMSLLLHRIGDVTLKVFRS-SRPLLHVLKVWAITGPHLMDAACHRDRMISKRAIEY 1104
            : .|.......:|.|.|:|:..|::.|| :||||||::.|::..|||::||||::|.:|::|:.:
Human  1169 E-VKSTQDRKSALHLFRLGNAMLRIVRSKARPLLHVMRCWSLVAPHLVEAACHKERHVSQKAVSF 1232

  Fly  1105 IHDIITALLVEQSELPYFHFNEALLKPFENLLSMD-TDVDVQDQIVACLYEVVEAHRTEIRSGWR 1168
            ||||:|.:|.:.:|.|:|||||||.:|||.::.:: .|.|||||:|..:.|:||...|:|:||||
Human  1233 IHDILTEVLTDWNEPPHFHFNEALFRPFERIMQLELCDEDVQDQVVTSIGELVEVCSTQIQSGWR 1297

  Fly  1169 PLFGTLRNA----RSRM-----------LNMSNIIDIFRVFLDSDNTLVFANAGLDCILCLLSYL 1218
            |||..|...    :|.|           ...:.:.|:|..||::||..|||||....|:||:.:
Human  1298 PLFSALETVHGGNKSEMKEYLVGDYSMGKGQAPVFDVFEAFLNTDNIQVFANAATSYIMCLMKF- 1361

  Fly  1219 EISGGGNNNACSGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETLRFLERCSSILGFMHSMPKCP 1283
             :.|.|..:....|..:.|.|..|             ||.....|.:|.|||.:|..::.||..|
Human  1362 -VKGLGEVDCKEIGDCAPAPGAPS-------------TDLCLPALDYLRRCSQLLAKIYKMPLKP 1412

  Fly  1284 NFHSTYKIKGISYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHIDKDTIVKIDEMDK 1348
            .|.|...           |.:|..::..:....|.:::                    .:.:.|.
Human  1413 IFLSGRL-----------AGLPRRLQEQSASSEDGIES--------------------VLSDFDD 1446

  Fly  1349 PSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASPGIDFGFYCINHLLVPMIQDW 1413
            .:|:::||.:||:.||.::..||..||.|.|..:|:|.:::..:||..||.|.:.|||:|::..|
Human  1447 DTGLIEVWIILLEQLTAAVSNCPRQHQPPTLDLLFELLRDVTKTPGPGFGIYAVVHLLLPVMSVW 1511

  Fly  1414 LRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIEKSVPEQRRLGAGTKTRLAQIVHPADNLLYSK 1478
            ||..:|..|.|.:...||||...::.:||||.|:                         :.|:|.
Human  1512 LRRSHKDHSYWDMASANFKHAIGLSCELVVEHIQ-------------------------SFLHSD 1551

  Fly  1479 LKFVTERIEREQQQQQSPSVQDHGCGYTQQYDSSSSSASEEQQKNGGGVGGGGSNLIESPTKISG 1543
            ::                            |:|..::
Human  1552 IR----------------------------YESMINT---------------------------- 1560

  Fly  1544 SATLALKQLLLVLIECAAQSQEAIARISVSCLKHVILSTGMLFNESQWMIACSAIHRACTVTIAP 1608
                .||.|..:|:.|.|:..|.|:|:..||:::|:::.|.:|.|..|.:||.|:..|.:.|:.|
Human  1561 ----MLKDLFELLVACVAKPTETISRVGCSCIRYVLVTAGPVFTEEMWRLACCALQDAFSATLKP 1621

  Fly  1609 LRQLSFAFHEKSNSFYGDCANVKVAARRDS-SLE-ELARIYALAQQVFLSDNQREPGQNQAPTPS 1671
            ::.|...||..:.||.|:...|:|||...| |.| |..||.|:|||||:.|.|..|     .||:
Human  1622 VKDLLGCFHSGTESFSGEGCQVRVAAPSSSPSAEAEYWRIRAMAQQVFMLDTQCSP-----KTPN 1681

  Fly  1672 ----ASQCKL-----SDDRSYSFLLYPLNNGFNSNLDNFVIRIPFKNLVVGLLANQMLLQLVAKL 1727
                |..|:|     .|::.         ||....      .:.|:.:||.||::|:|||.:..:
Human  1682 NFDHAQSCQLIIELPPDEKP---------NGHTKK------SVSFREIVVSLLSHQVLLQNLYDI 1731

  Fly  1728 LLSRLKCVPQAVSTCIFDNYAASAASPSHDYDLDFRSKEI--LLRCVKQYLM------------S 1778
            ||...                ....||..:..:.....::  .||.:....:            :
Human  1732 LLEEF----------------VKGPSPGEEKTIQVPEAKLAGFLRYISMQNLAVIFDLLLDSYRT 1780

  Fly  1779 ALEFDSRPGLKFLMQKVSNIEYAANLYKQMTSSWMIYYIALVDSHLNDIVVYNLGPEDLNFIL-- 1841
            |.|||:.||||.|::|||.|..|||||:|...|:.||:.|||.:.|.:  ...:..|.:..:|
Human  1781 AREFDTSPGLKCLLKKVSGIGGAANLYRQSAMSFNIYFHALVCAVLTN--QETITAEQVKKVLFE 1843

  Fly  1842 ---------ESCS--------------------------RLNTTTVKKKEN-----FVRYL--FC 1864
                     :.||                          |:...:|:...|     .|:.|  .|
Human  1844 DDERSTDSSQQCSSEDEDIFEETAQVSPPRGKEKRQWRARMPLLSVQPVSNADWVWLVKRLHKLC 1908

  Fly  1865 LQDAWNLVCELYLSNSALH-EIESGSGKLRQKPPQLLHHPQTKPMCISLNGNGDAEMTDTGSGSG 1928
            ::     :|..|:.   :| ::|:    ..::||..    :..|..|..:...::....||..||
Human  1909 ME-----LCNNYIQ---MHLDLEN----CMEEPPIF----KGDPFFILPSFQSESSTPSTGGFSG 1957

  Fly  1929 S---------------GSSTS-----------PSKCVQLQEE-------ENV-----------TM 1949
            .               |.|.|           ||..|:.::.       ||.           |:
Human  1958 KETPSEDDRSQSREHMGESLSLKAGGGDLLLPPSPKVEKKDPSRKKEWWENAGNKIYTMAADKTI 2022

  Fly  1950 TTLISEFQ-------------------------PKCRSNPFDTNRQAKSSEAE-----SISPEIE 1984
            :.|::|::                         |:.:.:|.....|....:.:     |..||:.
Human  2023 SKLMTEYKKRKQQHNLSAFPKEVKVEKKGEPLGPRGQDSPLLQRPQHLMDQGQMRHSFSAGPELL 2087

  Fly  1985 QQ--------RASSI---LKDSNYKRAALAQLVVASMELLRSLPGEAEENLKLLMTPTIRE 2034
            :|        ..||:   ::|:..:..|...:|:..:..::.||.:....|:..:.|.|.:
Human  2088 RQDKRPRSGSTGSSLSVSVRDAEAQIQAWTNMVLTVLNQIQILPDQTFTALQPAVFPCISQ 2148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	74/356 (21%)
CG5937	NP_001096888.2	DUF1981	1115..>1179	CDD:286414	32/68 (47%)
ARFGEF3	NP_065073.3	DCB	5..168	CDD:292830	48/165 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..301		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..542		5/32 (16%)
		Sec7	586..798	CDD:214569	59/220 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..636		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1031..1076		12/55 (22%)
		DUF1981	1246..>1303	CDD:286414	31/56 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1848..1877		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1946..2004		10/57 (18%)
		CBM_15	<1976..2055	CDD:281427	10/78 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2033..2064		2/30 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2082..2103		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	327	1.000	Domainoid score	I1174
eggNOG	1	0.900	-	-		E1_KOG1846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41366
Inparanoid	1	1.050	565	1.000	Inparanoid score	I1082
Isobase	1	0.950	-	0	Normalized mean entropy	S7625
OMA	1	1.010	-	-		QHG50118
OrthoDB	1	1.010	-	-		D27409at33208
OrthoFinder	1	1.000	-	-		FOG0007013
OrthoInspector	1	1.000	-	-		oto91391
orthoMCL	1	0.900	-	-		OOG6_107978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4037
SonicParanoid	1	1.000	-	-		X5110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720