DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5937 and arfgef3

DIOPT Version :9

Sequence 1:	NP_001096888.2	Gene:	CG5937 / 31537	FlyBaseID:	FBgn0029834	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_009305335.1	Gene:	arfgef3 / 562652	ZFINID:	ZDB-GENE-081107-37	Length:	2184	Species:	Danio rerio

Alignment Length:	2409	Identity:	604/2409 - (25%)
Similarity:	995/2409 - (41%)	Gaps:	601/2409 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDLFLLIIKESTGTKHNALRQTAQIAYDKLYRQHGIHRDPSHELRSVCFTALQMALDTKRPKFI 65
            ||::...:.||::|:|:.|:|.:..:|.:.|..|:|..:....:||..|...||:||::|..|..
Zfish     1 MEEILRRLQKEASGSKYRAIRDSCGVACETLQAQNGSVKISPSKLREKCLFPLQLALESKNTKLA 65

  Fly    66 TMGLNGLHRVIKDERFYIGLEPEDDSVWLPSQLLRATNGILPTTSSEDTVVNVLRLFLAMACSPA 130
            ...|.|:.:::.::.| :.:|.|.....|..|:|.|.. :.|:. .||..|.|:::.|.:..|..
Zfish    66 QTALTGMQKILCEDCF-LAVEAEAPEKQLLGQILEAVR-VTPSL-HEDLQVEVMKVLLCVTYSST 127

  Fly   131 CTLNGRLLIEILSRCGECW--EMGSRATKAASLAAASQCLRTFCAFLIEEAEEV----------- 182
            ..:.||.:::|...|.|.:  ....|:...|..|..||.|......|....|..
Zfish   128 FEITGRNILKIAEVCIETYISSCHQRSINTAVRATLSQILGDLTLQLRHRQENTDVDGEEQCIPV 192

  Fly   183 ---KKTAPAGLMTQTQASAVYNEVIPVMQWLCSRLVEPNVNASPNKKCENHSSLYLTECILTLSS 244
               |..:|:       ..|:|.:|:.|:...|.:|      .|.:.:.:....||| |.||::.|
Zfish   193 HQRKDVSPS-------TEALYEDVVMVLTVFCDKL------ESVSNENQLLQLLYL-ESILSMLS 243

  Fly   245 ALPRNVHANPHFTSFLWQKFCPTLAAALGSPGRINLDKKFT------YKDAL----HMIENEARG 299
            :.|..:|...:||..:|::.||||...:|:|..   ||..|      .:|::    ..:.::.||
Zfish   244 SCPPTMHLQRNFTDLVWKQLCPTLVVIMGNPAS---DKSITSAHGAQCQDSVSAPGSAVLDQGRG 305

  Fly   300 ---FFTGPGLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCVREI 361
               ..:.|.:.||..|.:...|.:|:|:.|...|::|:|::|:||:||.|.||:|.|.::.::||
Zfish   306 SGCSSSAPLMIGPVVRTICYVAAELVRLVGCVESMKPVLQSLYHRILLYPPPQHRVEAIKIMKEI 370

  Fly   362 FKSPERLIDLAVILYVDKNTAQGC----SDEMALFRLLVDAMEECAYGASGGGSATEASLQASVE 422
            ..||:||.|||....::..|.:..    ...:.|.:|::|.:.|..  ..||..|    ..:||.
Zfish   371 VGSPQRLFDLAGPCVIEHETRKRSFSKRKSHLDLLKLVMDGITEAC--MKGGIEA----CYSSVS 429

  Fly   423 CMVALLDSLQVLCSGELTES----MISDQIVQVVNGRHDL-----LKDADY-------------- 464
            |..|||.:|..|..|...:.    |:..::.::..|...:     :.:||:
Zfish   430 CAGALLGALDELSQGRGLQQDQTRMLLRRLEELKEGAESMRESVEVNEADFRWQRRVLSSENAAW 494

  Fly   465 ------------------SGPLTYQ---------------------SMARLPAP----------- 479
                              :|..|.:                     ...|||:|
Zfish   495 EASITERSPDISISVTTDTGQTTLEGDVGQTTLEGDMGRTTPEDCGDEPRLPSPTCGSRQECVAP 559

  Fly   480 -------------------YRDAIVEFRQTVFETSSGSESEGEPQHEQD---------------- 509
                               |.| |..|......|.|......|.....|
Zfish   560 EISSSTAPPDVVQRSHGLAYPD-ITNFLSVESRTRSHGSRYSESNFSADEQELSRTEFDSCDQYS 623

  Fly   510 -AASNGSGDTEGPE-DDDPSSSSDETSRVENRWPYSHLEAPVMPIR--TDSDNDRQHARDFARAL 570
             ||...||.::..: ..|..|.:||.....:...:..|....:.::  .:.:.|:|.||.|.::|
Zfish   624 MAAEKDSGRSDVSDMGSDNCSLADEEQTPRDCPGHRTLRTAALSLKLLKNQEADQQSARLFVQSL 688

  Fly   571 RQDLVPKLLRLRSCVELDEAMQEFASAVC---QENSMNFSDFDYN-----LTAINADGIYLAIYS 627
             ..|:|:||.|.|..::|..:|.|:|..|   |...::...|:.|     ...:||||:||..|.
Zfish   689 -ATLLPRLLGLHSTTDVDATLQNFSSTFCSGLQAGGVHSPGFEGNENLNCQALMNADGLYLVSYY 752

  Fly   628 SLLLSLQLMRAGFYEQVAQGMSHKDILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQSVTVCNV 692
            :|||:|:|....:|.:       |.....:|.::||..:|::||||.||..|:.|||..|...|:
Zfish   753 ALLLNLKLCCCDYYHR-------KPTSALVSLKEFVRQIQSSGVLVVLSQAWIEELYNQVLERNL 810

  Fly   693 L-----------EAMPRQQLEGMGPRCALVDMLCDAGGLGATQMLSEWQRLQTANVKHKEEEQLH 746
            |           :::|            |:.||.|..|||::.:..:..|..::......::..:
Zfish   811 LGEAGYWGSAEEQSLP------------LITMLTDIDGLGSSAIGGQLIRKASSQSPFTCDKNGN 863

  Fly   747 DKRREAAKKLCRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALY 811
            |. ..|.....|.:||.||.:::..||:.|......|:.:....|....::.:.:..:..    .
Zfish   864 DS-LVAGVVFARYILTGCWKNLIDTLSTPLTGRMAGSSRSLAFILGAEGVKEQTQRERDT----I 923

  Fly   812 AMCLDGLHSAATLSNSLNLQHLAGKILNLLASNVC------------------------------ 846
            .:.||||..||.||.:|.:.......|..:|:..|
Zfish   924 CLSLDGLRKAAALSCALGVAANCASALAQMAAASCVQEDKEEKELGDTGDAITQVKQRVEQKLEQ 988

  Fly   847 --QTSGPRISASQAMSMDVVLTGGLNLGSYSADCWPSIFAVCRHVSQLEHEIFS---MQNP-AIS 905
              ::.|.|:..:..:.||.:|..||.:||::.||||.:|.|..:||.|||..||   .|.| ||:
Zfish   989 MSRSQGVRLHTAHVLCMDAILNVGLEMGSHNHDCWPHVFRVIEYVSTLEHTHFSDGGSQPPLAIT 1053

  Fly   906 ASPGSSRRDLETGEKLSNGNAQDKLNLSSIPIDDDETCVDVYSFLQAPMQSPNTNITSILK---- 966
            .:..:...||:.|..|| .....:|.||                |..|:..| .:|..:||
Zfish  1054 QAQQAVAVDLDLGLDLS-AEVSPELELS----------------LSQPVIQP-LSIQQLLKDSAR 1100

  Fly   967 -----VYSGTNETVLLSQSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYK 1026
                 :..|:    ||:.:..:|.:|.||.||:.||.||..:|:|.||..||..|.:||:.||:.
Zfish  1101 GKALDLRGGS----LLTGTSAAKAVCTLSTQADRLFEDAVSKLNLVSLVGFLHQLRKASQSQLFD 1161

  Fly  1027 SQVARKGSRIWWPSKGWKKLDSLPMSLLLHRIGDVTLKVFRS-SRPLLHVLKVWAITGPHLMDAA 1090
            |........:..|.:. |.......:|.|.|:|:..|::.:: ||||||:::.|::..|||::||
Zfish  1162 SVTETGDYSLAMPGEA-KSTQDKRSALHLFRLGEAMLRIVKNKSRPLLHMMRAWSVVAPHLVEAA 1225

  Fly  1091 CHRDRMISKRAIEYIHDIITALLVEQSELPYFHFNEALLKPFENLLSMD-TDVDVQDQIVACLYE 1154
            ||::|.:|::|:.:|||::..:|....|||:|||||||.:|||:::.:: .|.|||||::..:.|
Zfish  1226 CHKERHVSQKAVSFIHDVLMEVLSSWPELPHFHFNEALFRPFEHIMQLELCDEDVQDQVITSIGE 1290

  Fly  1155 VVEAHRTEIRSGWRPLFGTLRNARSRMLNMSN--------------IIDIFRVFLDSDNTLVFAN 1205
            :||....:|:|||||||..||.......::.:              :.|:|..|:::||..||||
Zfish  1291 LVEMCSAQIQSGWRPLFSALRTVHGNKTDVKDYLIGEYSMGKSQAPVFDVFEAFINTDNIQVFAN 1355

  Fly  1206 AGLDCILCLLSYLEISGGGNNNACSGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETLRFLERCS 1270
            |..|.|:||:.:  :.|.|..:....|......|.:|             ||.....|.:|.:||
Zfish  1356 AATDYIMCLMKF--VKGLGEVDYKEIGDCVHVSGYSS-------------TDLCLPALDYLRKCS 1405

  Fly  1271 SILGFMHSMPKCPNFHSTYKIKGISYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHI 1335
            .:|..::.||..|.|              :.|.:.|            |..|     :..||:..
Zfish  1406 QLLAKIYKMPSKPVF--------------LGARLAS------------LPMR-----VQERSVSS 1439

  Fly  1336 DKDTIVKIDEMDKPSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASPGIDFGFY 1400
            :......:.|.|..:|:::||.|||:.||.::..||..||.|.|:.:|:|.:.:...||..|..:
Zfish  1440 EDGLDCVLAEFDDDTGLIQVWILLLEQLTAAVSNCPRQHQPPTLELLFELLREVTKIPGPGFAIF 1504

  Fly  1401 CINHLLVPMIQDWLRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIEKSVPEQRRLGAGTKTRLA 1465
            .:..||:|::..||:..:...|.|.:...||||...::.:||||.|.
Zfish  1505 SVIQLLLPVMSLWLQRSHGDHSYWDIAAANFKHAIGLSCELVVEHIH------------------ 1551

  Fly  1466 QIVHPADNLLYSKLKFVTERIEREQQQQQSPSVQDHGCGYTQQYDSSSSSASEEQQKNGGGVGGG 1530
                   :.::|.:                        ||
Zfish  1552 -------SFIHSDI------------------------GY------------------------- 1560

  Fly  1531 GSNLIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKHVILSTGMLFNESQWMIAC 1595
             .:||          .|.||.|..:|:.|.|:..|.|:|:..||:::|:::.|.:|.|..|.:||
Zfish  1561 -ESLI----------NLMLKDLFKLLVSCVAEPAETISRVGCSCIRYVLVTAGPVFTEEMWRLAC 1614

  Fly  1596 SAIHRACTVTIAPLRQLSFAFHEKSNSFYGDCANVKVAA--RRDSSLEELARIYALAQQVFLSDN 1658
            .|:..|.:.|:.|::.|...|...|:||.||...|||||  ...|:..|..||.|:|||||:.|.
Zfish  1615 CALQDAFSATLEPVKNLLACFRSGSDSFTGDACEVKVAAPSHSPSAEAENMRIRAMAQQVFMLDT 1679

  Fly  1659 QREPGQNQAPTPS-------ASQCKLSDDRSYSFLLYPLNNGFNSNLDNFVIRIPFKNLVVGLLA 1716
            |..|     .|||       |..|.|       .:..|.:...|.......|.|||:.|||.||:
Zfish  1680 QCSP-----KTPSSKDGFEHAQSCVL-------IIELPADQHSNGQAQKRKIGIPFRTLVVSLLS 1732

  Fly  1717 NQMLLQLVAKLLLSRLKCVPQAVSTCIFDNYAASAASPSH--DYDLDFRSKEILLRCVKQYLMSA 1779
            :|:|||.:..:||.......:...|      |.|...|:.  .| :..::..|:...:.....:|
Zfish  1733 HQVLLQNLYDILLEEFVKGSEGKIT------AVSEPKPAGFLRY-ISMQNLAIIFDLLLDSYRTA 1790

  Fly  1780 LEFDSRPGLKFLMQKVSNIEYAANLYKQMTSSWMIYYIALVDSHLNDIVVYNLGPEDLNFIL--- 1841
            .|||:|||||:|:.|||.:..|||||:|...|:.||:.||:.:.|.:  ..|:..|.:..||
Zfish  1791 REFDTRPGLKYLLMKVSGVCGAANLYRQSAMSFNIYFQALLCAMLTN--QENMSVEQVKKILSEE 1853

  Fly  1842 --------ESCS-----------RLNTTTVKKKENFVRYLFCLQD--------AWNL-------- 1871
                    :.||           :::....::|..:...:..|..        ||.:
Zfish  1854 EEGGSDSSQQCSSEDEDIFEEMAQVSPPRAREKRQWHTRIPSLSTQPASSADWAWLVKRLHKLCM 1918

  Fly  1872 -VCELYLSNSALH-EIESGSGKLRQKPPQLLHHPQTKPMCISLNGNGDAEMTDTGSGSGSGSSTS 1934
             :|..|:.   :| ::||..|:      |..|  :..|:......|.:.....||..||.|:.:.
Zfish  1919 DLCNNYIQ---MHLDLESTLGE------QPTH--RADPLFFLPLFNSETSTPSTGGLSGHGTPSE 1972

  Fly  1935 PSKCVQLQE--EENV-------------------------------------TMTTLISEFQPKC 1960
            .|..:.|.|  .|:|                                     |:|.|:.|::.:.
Zfish  1973 DSFRLNLDETPSEDVHSPGGSNASFPQRRDGGRKKEWWESAGNKLYTIATDKTITKLMIEYKKRK 2037

  Fly  1961 RSNPFDTNRQAKSSEAE---------------------------------SISPEIEQQR----- 1987
            :....:....||..:|.                                 |..||:.:|.
Zfish  2038 QQQQHNHTMFAKDVKAGEKRGEPVTLRGPDSPGPQRPQQLVEQGPMRHSFSAGPELLRQEKRPRS 2102

  Fly  1988 ---ASS---ILKDSNYKRAALAQLVVASMELLRSLPGEAEENLKLLMTPTIREAFRLVQLQGNEL 2046
               |||   .|:||..:..|...:|:..:..::.||......|:..:.|.|.:    :.....||
Zfish  2103 GSTASSHNISLRDSEAQIQAWTNMVLTILNQIQLLPDPTFMALQPAVFPCISQ----LTCHVTEL 2163

  Fly  2047 KVNQ 2050
            :|.|
Zfish  2164 RVRQ 2167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	75/356 (21%)
CG5937	NP_001096888.2	DUF1981	1115..>1179	CDD:286414	32/64 (50%)
arfgef3	XP_009305335.1	DCB	5..167	CDD:292830	45/164 (27%)
		Sec7	594..810	CDD:294092	61/223 (27%)
		DUF1981	1252..>1313	CDD:286414	32/60 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	332	1.000	Domainoid score	I1121
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41366
Inparanoid	1	1.050	682	1.000	Inparanoid score	I682
OMA	1	1.010	-	-		QHG50118
OrthoDB	1	1.010	-	-		D27409at33208
OrthoFinder	1	1.000	-	-		FOG0007013
OrthoInspector	1	1.000	-	-		oto41101
orthoMCL	1	0.900	-	-		OOG6_107978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4037
SonicParanoid	1	1.000	-	-		X5110
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910