Protein Alignment CG5937 and Sec71

DIOPT Version :9

• Sequence 1: NP_001096888.2
• Gene: CG5937 / 31537
• FlyBaseID: FBgn0029834
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Alignment Length: 2129
• Identity: 371/2129 - (17%)
• Similarity: 665/2129 - (31%)
• Gaps: 809/2129 - (37%)

  Fly    17 HNALRQTAQI----AYDKLYRQHGIHRDPSHELRSVCFTAL------------------------ 53
            ||...:|.::    |.:|:.....|.|....:|:..|.:||
  Fly     2 HNNSTKTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAAL 66

  Fly    54 --------------------QMALDTKRPKFITMGLNGLHRV---------IKD---------ER 80
                                ::|..::.|:.:...|:.|.::         |:|         :|
  Fly    67 PLPKNDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDR 131

  Fly    81 FYIGL-----EPE-DDSVWLPSQLLRA------------------------------TNGILPTT 109
            ..:.:     .|: |::|.|  |:::|                              :..::..|
  Fly   132 IVVTIYGCFSGPQTDEAVQL--QIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQT 194

  Fly   110 SSEDTVVNVLRLFLAMACSPACTL--------NGRLLIEILSRCGECWEMGSRATKAASLAAASQ 166
            ::..|:..:|.:..|...:....|        ||.:..|      :|...|..:.:.:....||:
  Fly   195 TARATLTQMLNVIFARMENQVYELPPPNSNPTNGSIHSE------DCNGSGEESLRDSDEVIASE 253

  Fly   167 CLRTFCAFLIEEA----EEVKKTAPA----------------------GLMTQTQASAVYNEVIP 205
            .|....:....||    |.|.:..|.                      .::|......:..:...
  Fly   254 LLAEIISAAYNEAMKDQESVGEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFL 318

  Fly   206 VMQWLCSRLVEPNVNASPNKKCENHSS--LYLTECILTLSSALPRNVHANPHFTSFLWQKFCPTL 268
            |.:.||...::|..:..|:.|.....|  |.|...:|.|.:|.| ...:|..|...:.|..|
  Fly   319 VFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGP-VFRSNEMFIMAIKQYLC--- 379

  Fly   269 AAALGSPGRINLDKKFTYKDALHMIENEARGFFTGPGLDGPQARCVYLTAIQLLRIAGAHGSLRP 333
             .||.:.|...:.:.|....::.                           :.||.....|  |:.
  Fly   380 -VALSNNGVSLVPEVFELSLSIF---------------------------VALLSNFKVH--LKR 414

  Fly   334 MLEALFHRMLL--LPAPQNRTE----PLRCVREIFKSPERLIDLAVILYVDKNTAQGCSDEMALF 392
            .:|..|..:.|  |.|..:..|    .::.:..|....:.::|:.|....|.:.|.       ||
  Fly   415 QIEVFFKEIFLNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFSAAN-------LF 472

  Fly   393 RLLVDAMEECAYGAS----GGGSATEASLQ-ASVECMVALLDSLQVLCSGEL------------- 439
            ..||:.:.:.|.|..    |.....|.|:: ..:||:|::|..: |..|.:|
  Fly   473 ERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSILKCM-VEWSKDLYVNPNMPVPPMQV 536

  Fly   440 -----TESMISDQIVQV--------VNGRHDLLKDADYSGPLTYQSMARLPAPYRDAIVE--FRQ 489
                 ||...:|..:|.        :|...:.|:|              ||    :|:.|  .|:
  Fly   537 QSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQLQD--------------LP----EALEERKMRK 583

  Fly   490 TVFETSSGSE-SEGEPQ------HEQDAASNGSGDTEGPEDDDPSSSSDETSRVENRWPY--SHL 545
            .|.||  |.| ...:||      .|:.......||..                   ||.:  ..|
  Fly   584 EVMET--GIELFNRKPQKGVQFLQEKQLLGATCGDIA-------------------RWLHEDERL 627

  Fly   546 EAPVMP--IRTDSDNDRQ------HARDFARALRQDLVPKLLRL--------RSCVELDEAMQEF 594
            :..|:.  |..:.|:.::      .|.||    ||..|...||.        ....::|..|::|
  Fly   628 DKTVIGNYIGENDDHSKEVMCAYIDAFDF----RQMEVVAALRFLLEGFRLPGEAQKIDRLMEKF 688

  Fly   595 ASAVCQENSMN--FSDFDYNLTAINADGIYLAIYSSLLLSLQLMRAGFYEQVAQGMSHKDILVPM 657
            ||..|:.|..|  |.         :||.:|:..:|.::|:..|.        :..:.||     |
  Fly   689 ASRYCECNPKNQLFQ---------SADTVYVLAFSIIMLTTDLH--------SPQVKHK-----M 731

  Fly   658 SEQQFVTSVQNTGVL--------VYLSSPWLCELYQSVTVCNVLEAMPRQQLEGMGP-------- 706
            :::|::.  .|.|:.        .||||     :|..::...:........|:...|
  Fly   732 TKEQYIK--MNRGISDSKSDLPEEYLSS-----IYDEISEHEIKMKNNSGMLQQAKPTGKQAFIT 789

  Fly   707 ---RCALVDMLCDAGGLGATQMLSEWQRLQT--ANVKHKEEEQLHDKRREAAKKLCRRLLTCCWD 766
               |..|.:|..:...|.||.::.....:::  .:.||.|.              .|.:....|.
  Fly   790 EKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEH--------------VRPMFKMAWT 840

  Fly   767 SMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYAMCLDGLHSAATLSNSLNLQ 831
            ..:...|.||.|                          .:...:..:||||:..|..::...::.
  Fly   841 PFLAAFSVGLQD--------------------------CDDPEIATLCLDGIRCAIRIACIFHMS 879

  Fly   832 HLAGKILNLLASNVCQTSGPRISASQAMSMDVVLTGGLNL-----GSYSADCWPSIFAVCRHVSQ 891
            ......:..||......:...|:..:|.::|.:.|  |.:     |:|....|   ..:.:.:||
  Fly   880 LERDAYVQALARFTLLNANSPINEMKAKNIDTIKT--LIMVAHTDGNYLGSSW---LDIVKCISQ 939

  Fly   892 LEHEIFSMQNPAISASPGSSRRDLETGEKLSNGNA--QDKLNLSSIPIDDDETCVDVYSFLQAPM 954
            ||          ::...|:..|.    :.||....  :|.|| .|:.....||
  Fly   940 LE----------LAQLIGTGVRP----QFLSGAQTTLKDSLN-PSVKEHIGET------------ 977

  Fly   955 QSPNTNITSILKVYSGTNETVLLSQSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRA 1019
             |..:.:.::.::::|                      :..|.|||        :..|:|.||:.
  Fly   978 -SSQSVVVAVDRIFTG----------------------SMRLDGDA--------IVDFVKALCQV 1011

  Fly  1020 SRDQLYKSQVARKGSRIWWPSKGWKKLDSLPMSLLLHRIGDVTLKVFRSSRPLLHVLKVWAITGP 1084
            |.|:|.:.|                     |....|.:|  |.:..:...|..|...::|.:.|.
  Fly  1012 SVDELQQQQ---------------------PRMFSLQKI--VEISYYNMERIRLQWSRIWQVLGE 1053

  Fly  1085 HLMDAACHRDRMISKRAIEYIHDIITALLVEQSELPYFHFNEALLKPFENLLSMDTDVDVQDQIV 1149
            |.....|:.:..||..|::.:.. ::...:|:.|...|.|.:..|:|||:::..:....::|.:|
  Fly  1054 HFNAVGCNSNEEISFFALDSLRQ-LSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVV 1117

  Fly  1150 ACLYEVVEAHRTEIRSGWRPLFGTLRNARSRMLNMSNIIDI----------------FRVFLDSD 1198
            .|:.::|.:....|||||:.:|.....|...  |...|:::                |.:.:||.
  Fly  1118 RCIAQMVNSQAHNIRSGWKNIFSIFHLAAGD--NEEPIVELAFQTTGKIIGDLYKRQFAIMVDSF 1180

  Fly  1199 NTLVFANAGLDCILCLLSYLEISGGGNNNACSGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETL 1263
            .         |.:.||                                 .|..|.|..|...|.:
  Fly  1181 Q---------DAVKCL---------------------------------SEFATARFPDTSMEAI 1203

  Fly  1264 RFLERCSSILGFMHSMPKCPNFHSTYKIKGISYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMI 1328
            |.:..|:..   :|..|:....|                   :.|||
  Fly  1204 RLVRTCAQC---VHEAPQLFAEH-------------------AGMEN------------------ 1228

  Fly  1329 SYRSLHIDKDTIVKIDEMDKPSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASP 1393
                       ...:.|.|:.  .::.||.:|..|:..:..|....:...|..:|::.|..
  Fly  1229 -----------DASVAEEDRV--WVRGWFPMLFSLSCVVNRCKLDVRTRALTVLFEIVKTY---- 1276

  Fly  1394 GIDFG-----------FYCINHLLVPMIQDWLRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIE 1447
            |..|.           |...:::.:|      .::.:. |.|            |||
  Fly  1277 GESFKPHWWKDLFNVIFRIFDNMKLP------EHVTEK-SEW------------MTT-------- 1314

  Fly  1448 KSVPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTERIEREQQQQQSPSVQDHGCGYTQQYDSS 1512
                                  ..::.||:.:..                       :||.:|
  Fly  1315 ----------------------TCNHALYAIIDV-----------------------FTQYFD-- 1332

  Fly  1513 SSSASEEQQKNGGGVGGGGSNLIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKH 1577
                                        :.|.  |.|::|...|..|..||.|.:||...:||::
  Fly  1333 ----------------------------VLGH--LLLEELFAQLHWCVQQSNEQLARSGTNCLEN 1367

  Fly  1578 VILSTGMLFNESQWMIACSAIHRACTVTI--APLRQLSFAFHEKSNSFYGDCANVKVAARRDSSL 1640
            :::|.|..||||.|...|.     |.:.|  |.|.|...::..|::|    ..|:........:|
  Fly  1368 LVISNGFKFNESTWDKTCQ-----CILDIFNATLPQDLLSWRPKAHS----SNNIPQEHNHFEAL 1423

  Fly  1641 E-----ELARIYALAQQVFL-SDNQREPGQNQAPTP-------SASQ-----CKLSDDRSYSFL- 1686
            .     :|..|..:...||. :.:::|..:..|...       |.||     |:..:...|.:|
  Fly  1424 HIRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQLLECQREEQGMYGYLR 1488

  Fly  1687 -------------LYPLNNGFNSNLD--NFVIRIPFKNLVVGLLANQMLLQLVAKLLLSRLKCVP 1736
                         .:.....||::.|  :.:.|..||..|...|..|.         .|.|.||.
  Fly  1489 TRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQE---------TSSLACVL 1544

  Fly  1737 QAVSTCIFDNYAASAASPSHDYDLDFRS------KEILLRCVKQY-----LMSALEFDSRPGLKF 1790
            :    ..|..|.          |.:.||      :|::..|.:..     |.|....|:...|..
  Fly  1545 R----IFFKMYG----------DENRRSDWPGIEQELVQVCKEALGYYLSLQSEAHRDAWTSLLL 1595

  Fly  1791 L----MQKVSNIEYAANLYKQMTSSWMIYYIALVDSHLNDIVVYNLGPE 1835
            |    :.|:|:..:|.::..        ||     |.|.:::.::|.||
  Fly  1596 LILTRLLKMSDARFATHVSN--------YY-----SLLCEMMCFDLKPE 1631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	58/285 (20%)
		DUF1981	1115..>1179	CDD:286414	19/63 (30%)
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	353/2052 (17%)
		DCB	30..212	CDD:292830	21/183 (11%)
		Sec7_N	312..465	CDD:289549	34/186 (18%)
		Sec7	582..767	CDD:279680	51/238 (21%)
		DUF1981	1080..1161	CDD:286414	21/82 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030