DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5937 and Arfgef3

DIOPT Version :9

Sequence 1:	NP_001096888.2	Gene:	CG5937 / 31537	FlyBaseID:	FBgn0029834	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_038954729.1	Gene:	Arfgef3 / 292947	RGDID:	1309903	Length:	2170	Species:	Rattus norvegicus

Alignment Length:	2231	Identity:	581/2231 - (26%)
Similarity:	956/2231 - (42%)	Gaps:	552/2231 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDLFLLIIKESTGTKHNALRQTAQIAYDKLYRQHGIHRDPSHELRSVCFTALQMALDTKRPKFI 65
            ||::...:.::::|:|:.|::::...|.:.|.....:.:.|.|.||..|...||:||::|..|..
  Rat     1 MEEILRKLQRDASGSKYKAIKESCTWALETLGGLDTVAKIPPHLLREKCLLPLQLALESKNVKLA 65

  Fly    66 TMGLNGLHRVIKDERFYIGLEPEDDSVWLPSQLLRATNGILPTTSSEDTVVNVLRLFLAMACSPA 130
            ...|.|:.:::.:||| :.:|.:.|...|.:|:|.|.. :.|:. :||..|.|:::.|.:..:|.
  Rat    66 QHALAGMQKLLSEERF-VSMETDSDDKQLLNQILNAVK-VTPSL-NEDLQVEVMKVLLCITYTPT 127

  Fly   131 CTLNGRLLIEILSRCGECWEMG--SRATKAASLAAASQCLRTFCAFLIEEAEEV---KKTAPAGL 190
            ..:||..:::|...|.|.:...  .|:...|..|..||.|......|.:..|..   ...||.|.
  Rat   128 FDMNGSAVLKIAEVCIETYTCSCHQRSINTAVRATLSQMLGDLTLQLRQRQENTIIENPDAPQGF 192

  Fly   191 MTQ-TQASAVYNEVIPVMQWLCSRLVEPNVNASPNKKCENHSSLYLTECILTLSSALPRNVHANP 254
            .:| ....|:.::|:.|:..||.:| :.::|.|     :....||| ||||::.|:...:::.:.
  Rat   193 RSQGLTVEALCDDVVSVLAVLCEKL-QASINDS-----QQLQLLYL-ECILSILSSSSSSMYLHR 250

  Fly   255 HFTSFLWQKFCPTLAAALGSPGRINLDKKFT-----------YKDALHM-IENEARG---FFTGP 304
            .||..:|:..||.|...||:|..   ||..|           ..|:..: :.:..||   ..|.|
  Rat   251 GFTDLIWKSLCPALVVILGNPIH---DKTITSAHSTSTGTSMESDSASLGVSDHGRGSGCSCTAP 312

  Fly   305 GLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCVREIFKSPERLI 369
            .|.||.||.:|..|.:|:|:.|:..||:|:|::|:||:||.|.||:|.|.::.:|||..||:||.
  Rat   313 TLSGPVARTIYYLATELVRLVGSVDSLKPVLQSLYHRVLLYPPPQHRVEAIKIMREILGSPQRLY 377

  Fly   370 DLAVILYVD----KNTAQGCSDEMALFRLLVDAMEECAYGASGGGSATEASLQASVECMVALLDS 430
            |||....::    |.:.......:.|.:|::|.|.|..  ..||..|    ..|:|.|:..||.:
  Rat   378 DLAGPSSLESEPRKRSISKRKSHLDLLKLIMDGMTEAC--IKGGIEA----CYAAVSCVCTLLGA 436

  Fly   431 LQVLCSGE-LTESMISDQIVQVVNGRHDL--------LKDADY---------------------- 464
            |..|..|: |.::.:...::::...|...        :.:||:
  Rat   437 LDELSQGKGLNDNQVQQLLLRLEELRDGAESSRDSMEINEADFRWQRKVLSSEHTPWETGNERSP 501

  Fly   465 ---------SGPLTYQSM--ARLPAPYRD-----AIVEFRQTVFETSSGSESEGEPQ-------- 505
                     :|..|.:..  ...|..:::     ||.|.|:|:.:.|. .|:..:|.
  Rat   502 DISISVTTDTGQTTLEGELGQTTPEDHKNGLKSPAIQEGRETMSKVSE-PETIDQPDVVQRSHTV 565

  Fly   506 -----------------------------HEQD--------------AASNGSGDTEGPE-DDDP 526
                                         .:||              ||...||.::..: ..|.
  Rat   566 PYPDITNFLSVDCRTRSYGSRYSESNFSVDDQDLSRTEFDSCDQYSMAAEKDSGRSDVSDIGSDN 630

  Fly   527 SSSSDETSRVENRWPYSHLEAPVMPIR--TDSDNDRQHARDFARALRQDLVPKLLRLRSCVELDE 589
            .|.:||.....:...:..|....:.::  .:.:.|:..||.|.::| :.|:|:||.|.|..|:|.
  Rat   631 CSLADEEQTPRDYMGHRSLRTAALSLKLLKNQEADQHSARLFIQSL-EGLLPRLLALSSVEEVDS 694

  Fly   590 AMQEFASAVCQENSMNFSDFDYNLT-----AINADGIYLAIYSSLLLSLQLMRAGFYEQ---VAQ 646
            |:|.|||..| ...|:...||...:     .:|||.:|.|.:.:|||:|:|....:|.:   ||.
  Rat   695 ALQNFASTFC-SGMMHSPGFDGGSSLSIQMLMNADSLYTAAHCALLLNLKLSHGDYYRKRPNVAP 758

  Fly   647 GMSHKDILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQSVTVCNVL-EA----MPRQQLEGMGP 706
            ||.          ::|:..||.:|||:..|..|:.||:..|...|:| ||    .|...
  Rat   759 GMM----------KEFMKQVQTSGVLMVFSQAWIEELFHQVLDRNMLGEAGYWGSPEDN------ 807

  Fly   707 RCALVDMLCDAGGLGATQMLSEWQRLQTANVKHKEEEQLHDKRREAAKKLCRRLLTCCWDSMVIV 771
            ...|:.||.|..||.::.:..:.....:......:..:|.|. ..|.....|.:|..||.:::..
  Rat   808 NLPLITMLTDIDGLESSAIGGQLMASASMESPFTQSRKLDDS-TVAGIAFARYILVGCWKNLIDT 871

  Fly   772 LSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYAMCLDGLHSAATLSNSLNLQHLAGK 836
            ||:.|......|:......|....::   :.|:...:|: .|.||||..||.||.:|.:......
  Rat   872 LSTPLTGRMAGSSKGLAFILGAEGIK---EQNQKERDAI-CMSLDGLRKAARLSCALGVAANCAS 932

  Fly   837 ILNLLASNVC--------------------------------QTSGPRISASQAMSMDVVLTGGL 869
            .|..:|:..|                                :..|..:..:..:.||.:|:.||
  Rat   933 ALAQMAAASCVQEEKEERESQEPSDALAQVKLKVEQKLEQMGKAQGVWLHTAHVLCMDAILSVGL 997

  Fly   870 NLGSYSADCWPSIFAVCRHVSQLEHEIFS--MQNPAI--------SASPG----------SSRRD 914
            .:||::.||||.:|.||.:|..|||..||  :..|.:        |.|.|          |..:.
  Rat   998 EMGSHNPDCWPHVFRVCEYVGTLEHTHFSDGLSQPPLTIHQPQKTSGSSGLLGELEFKSSSQEQS 1062

  Fly   915 LETGEKLSNGNAQDKLNLSSIPIDDDETCVDVYSFLQAPMQSPNTNITSILKVYSGTNETVL--- 976
            ||.|..|   ||                         ||:..|:| |..:::..|....:..
  Rat  1063 LEQGPSL---NA-------------------------APVVQPHT-IQELVRECSRGRTSDFRGG 1098

  Fly   977 -LSQSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIWWPS 1040
             ||.:..:||:.:||.||:.||.||.::|:|.:|..||..|.:||:.||:.|........:..|.
  Rat  1099 SLSGNSAAKVVLSLSTQADRLFDDATDKLNLTALGGFLYQLKKASQSQLFHSVTDTVDYSLTMPG 1163

  Fly  1041 KGWKKLDSLPMSLLLHRIGDVTLKVFRS-SRPLLHVLKVWAITGPHLMDAACHRDRMISKRAIEY 1104
            : .|.......:|.|:|:||..|::.|| :||||||::.|::..|||::||||::|.:|::|:.:
  Rat  1164 E-VKSTQDQKSALHLYRLGDAMLRIVRSKARPLLHVMRCWSLVAPHLVEAACHKERHVSQKAVSF 1227

  Fly  1105 IHDIITALLVEQSELPYFHFNEALLKPFENLLSMD-TDVDVQDQIVACLYEVVEAHRTEIRSGWR 1168
            ||||:|.:|.:.||.|:|||||||.:|||.::.:: .|.|||||:|..:.|:||....:|:||||
  Rat  1228 IHDILTEVLTDWSEPPHFHFNEALFRPFERIMQLELCDEDVQDQVVTSIGELVEVCSAQIQSGWR 1292

  Fly  1169 PLFGTLRNARSRMLNMSN-----------------IIDIFRVFLDSDNTLVFANAGLDCILCLLS 1216
            |||..|....|.  |.|.                 :.|:|..||::||..|||||....|:||:.
  Rat  1293 PLFSALETVHSG--NKSEVKEYLVGDYSMGKGQAPVFDVFEAFLNTDNIQVFANAATSYIMCLMK 1355

  Fly  1217 YLEISGGGNNNA-----CSGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETLRFLERCSSILGFM 1276
            :  :.|.|..:.     |..|:|:.:                  ||.....|.:|.|||.:|..:
  Rat  1356 F--VKGLGEVDCKEIGDCVPGAGATS------------------TDLCLPALDYLRRCSQLLAKI 1400

  Fly  1277 HSMPKCPNFHSTYKIKGISYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHIDKDTIV 1341
            :.||..|.|.|...           |::|..::..:....|.:::
  Rat  1401 YKMPLKPIFLSGRL-----------ASLPRRLQEQSASSEDGIES-------------------- 1434

  Fly  1342 KIDEMDKPSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASPGIDFGFYCINHLL 1406
            .:.:.|..:|::.||.:||:.||.::.:||..||.|.|..:|:|.:::..:||..||.|.:.|||
  Rat  1435 VLSDFDDDTGLIDVWIILLEQLTAAVSICPRQHQPPTLDLLFELLRDVTKTPGPGFGIYAVVHLL 1499

  Fly  1407 VPMIQDWLRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIEKSVPEQRRLGAGTKTRLAQIVHPA 1471
            :|::..|||..:|..|.|.:...||||...::.:||||.|:
  Rat  1500 LPVMSLWLRRSHKDHSYWDVASANFKHAIGLSCELVVEHIQ------------------------ 1540

  Fly  1472 DNLLYSKLKFVTERIEREQQQQQSPSVQDHGCGYTQQYDSSSSSASEEQQKNGGGVGGGGSNLIE 1536
             :.|:|.::                            |:|..::
  Rat  1541 -SFLHSDIR----------------------------YESMINT--------------------- 1555

  Fly  1537 SPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKHVILSTGMLFNESQWMIACSAIHRA 1601
                       .||.|..:|:.|.|:..|.|:|:..||:::|:::.|.:|.|..|.:||.|:..|
  Rat  1556 -----------MLKDLFELLVVCVAKPTETISRVGCSCIRYVLVTAGPVFTEEMWRLACCALQDA 1609

  Fly  1602 CTVTIAPLRQLSFAFHEKSNSFYGDCANVKVAARRDS-SLE-ELARIYALAQQVFLSDNQREPGQ 1664
            .:.|:.|::.|...||..:..|.|:...|:|||...| |.| |..||.|:|||||:.|.|..|
  Rat  1610 FSATLKPVKDLLGCFHSGTEGFSGEGCQVRVAAPSSSPSAEAEYWRIRAMAQQVFMLDTQSSP-- 1672

  Fly  1665 NQAPTPS----ASQCKL-----SDDRSYSFLLYPLNNGFNSNLDNFVIRIPFKNLVVGLLANQML 1720
               .||:    |..|:|     .|:|.         ||....      .:.|:.:||.||::|:|
  Rat  1673 ---KTPNNFDHAQSCQLIIELPPDERP---------NGHAKK------SVSFREIVVSLLSHQVL 1719

  Fly  1721 LQLVAKLLLSRLKCVP--------QAVSTCI--FDNYAASAASPSHDYDLDFRSKEILLRCVKQY 1775
            ||.:..:||......|        ||..|.:  |..|            :..::..::...:...
  Rat  1720 LQNLYDILLEEFVKGPSPGEEKTVQAPDTKLAGFLRY------------ISMQNLAVIFDLLLDS 1772

  Fly  1776 LMSALEFDSRPGLKFLMQKVSNIEYAANLYKQMTSSWMIYYIALVDSHLNDIVVYNLGPEDLNFI 1840
            ..:|.|||:.||||.|::|||.|..|||||:|...|:.||:.|||.:.|.:  ...:..|.:..:
  Rat  1773 YRTAREFDTSPGLKCLLKKVSGIGGAANLYRQSAMSFNIYFHALVCAVLTN--QETITAEQVKKV 1835

  Fly  1841 L-----------ESCS--------------------------RLNTTTVKKKEN-----FVRYL- 1862
            |           :.||                          ||.:.:|:...|     .|:.|
  Rat  1836 LFEEEERSSDSSQQCSSEDEDIFEETAQVSPPRGKEKRQWRARLPSLSVQPVSNADWVWLVKRLH 1900

  Fly  1863 -FCLQDAWNLVCELYLSNSALH-EIESGSGKLRQKPPQLLHHP---QTKPMCISLNGNGDAEMTD 1922
             .|::     :|..|:.   :| ::||.           |..|   ::.|..|..:...::....
  Rat  1901 KLCME-----LCNHYIQ---MHLDLESS-----------LEEPLAFKSDPFFILPSFQSESSTPS 1946

  Fly  1923 TGSGSGSGSSTSPSKCVQLQE 1943
            ||..||..:.:...:...|.|
  Rat  1947 TGGFSGKNTPSEDDRREHLSE 1967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	73/348 (21%)
CG5937	NP_001096888.2	DUF1981	1115..>1179	CDD:286414	32/64 (50%)
Arfgef3	XP_038954729.1	DCB	16..167	CDD:406594	43/153 (28%)
		Sec7	582..794	CDD:214569	59/223 (26%)
		DUF1981	1241..>1298	CDD:401312	30/56 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1233
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1366
OMA	1	1.010	-	-		QHG50118
OrthoDB	1	1.010	-	-		D27409at33208
OrthoFinder	1	1.000	-	-		FOG0007013
OrthoInspector	1	1.000	-	-		oto98468
orthoMCL	1	0.900	-	-		OOG6_107978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5110
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880