DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5937 and SPBC211.03c

DIOPT Version :9

Sequence 1:	NP_001096888.2	Gene:	CG5937 / 31537	FlyBaseID:	FBgn0029834	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	NP_596613.1	Gene:	SPBC211.03c / 2540746	PomBaseID:	SPBC211.03c	Length:	1462	Species:	Schizosaccharomyces pombe

Alignment Length:	1515	Identity:	269/1515 - (17%)
Similarity:	479/1515 - (31%)	Gaps:	527/1515 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IIKESTGTKHNALRQTAQIAYDKLY------------RQHGIHRDPSHELRSVCFTAL----QMA 56
            ::.|.:..|.:...:.:...||.|.            |..|.       :.|:|.:|:    ...
pombe    80 LVMEFSQLKEDLTNRASLNGYDSLKLLSPFLRTIKSPRMTGY-------ITSLCLSAILKFFSFR 137

  Fly    57 LDTKRPKFITMGLNGLHRVIKDERFYIGLEPEDDSVW-----LPSQLLRATNGILPTTSSEDTVV 116
            :.::....:.:.:..|...|...||......:|::|.     |..:|||   |......|:|::.
pombe   138 IISEESPNLALSMRNLSFAITQCRFESFDASQDEAVLLRVSRLMEELLR---GPGKAVLSDDSIC 199

  Fly   117 NVLRLFLAMAC----------SPACTLNGRL--------LIEILSRCGECWEMG----------- 152
            .::...|:|.|          |...::...|        .|::.:...:.|:..
pombe   200 EIVETGLSMCCQSRLSQVLRYSAELSMTSILEKIFERLKYIDVKTDSEDFWDASEEHSIKGEEFH 264

  Fly   153 ----------SRATKAASLAAASQCLRTFCAFL----IEEAEEVKKTAPAGLMTQTQASAVYNEV 203
                      |.......:.:..:..|...:|:    .:.::.:|..|...:.|..:.|..:...
pombe   265 YKKITEGDEISNEIDPFGIGSIREVFRVLVSFIDFGKQKFSDNIKAMALRFINTALEVSGSHISD 329

  Fly   204 IP-----VMQWLCSRLVEPNVNASPNKKCENHSSLYLTECILTLSSALPRNVHANPHFTSFLWQK 263
            .|     :...||..|::        ....:|::| ||..:|.:::.|    .|.|.......:.
pombe   330 FPSLRVLITDTLCKSLLQ--------LIRSDHTAL-LTNSLLVMTTLL----QAMPGSLKLQQEL 381

  Fly   264 FCPTLAAALGSPGRINLDKKFTYKDALHMIENEARGFFTGPGLD-----GPQARCVYLTAIQLLR 323
            |...|.:.|..|.  ...::...:.:||.:.:         .||     .|. |....:..:..|
pombe   382 FISYLISCLHIPS--TTPRERNVETSLHKVVS---------SLDLSEEISPD-RATPTSFTERKR 434

  Fly   324 IAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCVREIFKSPERLIDLAVILYVDKNTAQGCSDE 388
            .|....: ||              |:.|...:.|:..:.:.|..|||    |||:.:    |..:
pombe   435 FAFDTRN-RP--------------PEVRELIVECLGSLSRIPYFLID----LYVNYD----CDPQ 476

  Fly   389 MALFRLLVDAME----ECAYGASGGGSATEASLQASVECMVALL-------DSLQ---------- 432
            |:  .|.:|.::    .|...::...:|....|     |:.|||       :.||
pombe   477 MS--DLAIDLLKVLTRNCLVDSARYSTANVPPL-----CLDALLNFIYYFHEHLQPCYNDPNNTF 534

  Fly   433 -----------------VLCSGELTESMISDQIVQVVNGRHDLLKDADYSGPLTYQSMARLPAPY 480
                             ::...||.....||.|..:.  :|.::|.:|  .|
pombe   535 KDDVAKTLIESKKRKAIIIEGAELFNESPSDGIAFLT--QHSIIKQSD--NP------------- 582

  Fly   481 RDAIVEFRQTVFETSSGSESE----GEPQHEQDAASNGSGDTEGPEDDDP----------SSSSD 531
             ..||||..:....|.....|    |...|..:|..: :.|.:|...|:.          ...|.
pombe   583 -TCIVEFFHSTNRLSKRVLGEFLTKGSNSHILNAFIS-AFDFKGKRIDEALRLLLQSFRLPGESQ 645

  Fly   532 ETSRVENRWPYSHLEA----------------PVMPIRTDSDND------RQHARDFARALR--- 571
            ...||...:.:.::.|                .::.:.||..|.      |....||.|.:|
pombe   646 LIERVLETFSHYYMSANPDSMSSKDAAFVLSYSIIMLNTDQHNPNIKSQRRMTLDDFCRNVRGVN 710

  Fly   572 --QDLVPKLLRLRSCVELDEAMQEFASAVCQENSMNFSDFDYNLTAINADGIYLAIYSSLLLSLQ 634
              ||.....|.     |:.:|::|....|.:|:....|              :|.|:|.|..|::
pombe   711 DGQDFDRNFLS-----EIYKAIKENEIIVAEEHDTELS--------------FLYIWSKLQQSVK 756

  Fly   635 LMRAGFYEQVAQGMSHKDILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQSVT-VCNVLEAMPR 698
            :...  :::.:..:..|.:.:.:.:     |:....:.|:.::......|:.|. :....|....
pombe   757 ITEP--FKRSSSNVHDKIVFLEVWK-----SIMAALIYVFSTATEDTVFYRVVNGIQQATEVAAA 814

  Fly   699 QQLEGMGPRCALVDMLC-----DAGGLGATQMLSEWQRLQTANVKHKEEEQL-----------HD 747
            .:|.  .|....::..|     |...:..||:          |...|.|:::           .|
pombe   815 YELN--EPVDYAIERFCQFTALDPSSVPGTQL----------NTAIKVEDRIITVSELSVRFGRD 867

  Fly   748 KRREAAKKLCRRLLTCCWDSMVIVLSSGLGDLQTSS-----------ASNKLV------------ 789
            .|.:.|      ||...|      :||..|::..:|           |.|.|:
pombe   868 FRAQLA------LLVLFW------ISSKFGNIIDASWPLLVQLTICLARNNLIDNSFLPGFKLFG 920

  Fly   790 ----------------ALSKR-------TLRVKAKAN-----KSNGEALYAMCLDGLHSAATLSN 826
                            ||||.       :..:.:.||     .::.|..:.:|.....|:|.:.|
pombe   921 YQWFPFPEPPLNSGKPALSKEGGLLSALSSYLSSYANDEPPCPTDEEIQHTLCTIDCISSAKIDN 985

  Fly   827 SL-NLQHLAGKILNLLASNVCQTSGP--------------RISASQAMSMDVVLTGGLNLGS-YS 875
            .| .|..|....||.|..::...|.|              ::|:.:|:|         |:.| ..
pombe   986 FLTKLVDLKQPGLNKLLDSLLSLSNPSTSLLTDENTVDDNKVSSVEALS---------NIQSAIV 1041

  Fly   876 ADCWPSIFAVCRH---------------------------VSQLEHEIFSM-QNPAISASPGSSR 912
            ||...|:|...|.                           ::||...||.| .:..:..|..|
pombe  1042 ADLLTSLFLGTRESLNKLERRTQILSYLLFQIEQSGDEKVINQLSLYIFEMFMDDDLKLSENS-- 1104

  Fly   913 RDLETGEKLSNGNAQDKLNLSSIPIDDD-----ETCVDVYSF-------LQAPMQSPNTNITSIL 965
            .|.....||.|     .||..:|.:.:.     ...|:.|.|       ||....:.|||...|.
pombe  1105 EDWGLFSKLCN-----LLNDKNIVVRNQSLSLFHQLVNKYPFLLESWIGLQLVQSAVNTNTADID 1164

  Fly   966 KVYSGTNETVLLSQSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYKSQVA 1030
            .:|.      |||:..|            ||       |.||....:|.  |..:..|....|:|
pombe  1165 DLYR------LLSKIPT------------NL-------LDLPMFQVYLG--CVDTLIQTIVKQIA 1202

  Fly  1031 ------RKGSRIWWPSKGWKKLDSLPM--SLLLHRIGD------------VTLKV--------FR 1067
                  :||:     |||      ||.  |:|.:...:            |..||        |:
pombe  1203 QILSKQKKGA-----SKG------LPFDKSILDNHSAELNDAFNLFLKAAVEYKVDSNESSEHFQ 1256

  Fly  1068 SSRPLLHVLKVWAITGPHLMDAACHRDRMISKRAIEYIHDIITALLVEQSELPY----FHFNEAL 1128
            .:|        |.|...|:......|.|.:...::..:..|:...|.:..|:.|    ||.  .|
pombe  1257 DTR--------WKIIYDHVCKLCLSRSRSLRAASLSCLQRIVVEQLDQPHEVSYTMALFHL--VL 1311

  Fly  1129 LKPFENLLSMDTDVD-------VQDQI--VACL-----YEVVEAHRTEIRSGWRPL------FGT 1173
            |...||::::.|:..       .|.|:  :.|.     ..|:.|.:..:.:.|..|      ..:
pombe  1312 LPTMENMITVLTEKPEHKIFGLAQAQMFNIICKTVLIDMNVLSAQKEMLHTLWLKLMDVAIKLSS 1376

  Fly  1174 LRNARSRMLNMSNIIDIFRV 1193
            :..:.|....|.:|.::|.:
pombe  1377 IHGSESMAEVMESIKNVFMI 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	47/282 (17%)
CG5937	NP_001096888.2	DUF1981	1115..>1179	CDD:286414	16/87 (18%)
SPBC211.03c	NP_596613.1	Sec7_N	287..475	CDD:289549	43/235 (18%)
		COG5307	289..1303	CDD:227623	219/1199 (18%)
		Sec7	548..732	CDD:279680	39/207 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100