DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5937 and Arfgef3

DIOPT Version :9

Sequence 1:NP_001096888.2 Gene:CG5937 / 31537 FlyBaseID:FBgn0029834 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_001028430.1 Gene:Arfgef3 / 215821 MGIID:106387 Length:2170 Species:Mus musculus


Alignment Length:2408 Identity:597/2408 - (24%)
Similarity:996/2408 - (41%) Gaps:641/2408 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEDLFLLIIKESTGTKHNALRQTAQIAYDKLYRQHGIHRDPSHELRSVCFTALQMALDTKRPKFI 65
            ||::...:.::::|:|:.|::::...|.:.|.....:.:.|.|.||..|...||:||::|..|..
Mouse     1 MEEILRKLQRDASGSKYKAIKESCTWALETLGGLDTVVKIPPHLLREKCLLPLQLALESKNVKLA 65

  Fly    66 TMGLNGLHRVIKDERFYIGLEPEDDSVWLPSQLLRATNGILPTTSSEDTVVNVLRLFLAMACSPA 130
            ...|.|:.:::.:||| :.:|.:.|...|.:|:|.|.. :.|:. :||..|.|:::.|.:..:|.
Mouse    66 QHALAGMQKLLSEERF-VSMETDSDEKQLLNQILNAVK-VTPSL-NEDLQVEVMKVLLCITYTPT 127

  Fly   131 CTLNGRLLIEILSRCGECWEMG--SRATKAASLAAASQCLRTFCAFLIEEAEEV---KKTAPAGL 190
            ..:||..:::|...|.|.:...  .|:...|..|..||.|......|.:..|..   ...||...
Mouse   128 FDMNGSAVLKIAEVCIETYTCSCHQRSINTAVRATLSQMLGDLTLQLRQRQENTIIENPDAPQEF 192

  Fly   191 MTQ-TQASAVYNEVIPVMQWLCSRLVEPNVNASPNKKCENHSSLYLTECILTLSSALPRNVHANP 254
            .:| ....|:.::||.|:..||.:| :.::|.|     :....||| ||||::.|:...::|.:.
Mouse   193 RSQGLTVEALCDDVISVLAVLCEKL-QASINDS-----QQLQLLYL-ECILSVLSSSSSSMHLHR 250

  Fly   255 HFTSFLWQKFCPTLAAALGSPGRINLDKKFT-----------YKDALHM-IENEARG---FFTGP 304
            .||..:|:..||.|...||:|..   ||..|           ..|:..: :.:..||   ..|.|
Mouse   251 GFTDLIWKSLCPALVVILGNPIH---DKTITSAHSTSTSTSMESDSASLGVSDHGRGSGCSCTAP 312

  Fly   305 GLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCVREIFKSPERLI 369
            .|.||.||.:|..|.:|:|:.|:..|::|:|::|:||:||.|.||:|.|.::.::||..||:||.
Mouse   313 TLSGPVARTIYYLAAELVRLVGSVDSMKPVLQSLYHRVLLYPPPQHRVEAIKIMKEILGSPQRLY 377

  Fly   370 DLAVILYVD----KNTAQGCSDEMALFRLLVDAMEECAYGASGGGSATEASLQASVECMVALLDS 430
            |||....::    |.:.......:.|.:|::|.|.|..  ..||..|    ..|:|.|:..||.:
Mouse   378 DLAGPSSIESEPRKRSISKRKSHLDLLKLIMDGMTEAC--IKGGIEA----CYAAVSCVCTLLGA 436

  Fly   431 LQVLCSGE-LTESMISDQIVQVVNGRHDL--------LKDADY---------------SG----- 466
            |..|..|: |.::.:...::::...|...        :.:||:               ||     
Mouse   437 LDELSQGKGLNDTQVQQLLLRLEELRDGAESSRDSMEINEADFRWQRRVLSSEHTPWESGNERSP 501

  Fly   467 -----------------------PLTYQSMARLPA-----------------------------P 479
                                   |..:::..:.||                             |
Mouse   502 DISISVTTDTGQTTLEGELGQTTPEDHKNGLKSPAIQEGKGTMGKVSEPEAIDQPDVVQRSHTVP 566

  Fly   480 YRDAIVEFRQTVFETSSGSESEGEPQHEQD-----------------AASNGSGDTEGPE-DDDP 526
            |.| |..|......|.|......|.....|                 ||...||.::..: ..|.
Mouse   567 YPD-ITNFLSVDCRTRSYGSRYSESNFSVDDQDLSRTEFDSCDQYSMAAEKDSGRSDVSDIGSDN 630

  Fly   527 SSSSDETSRVENRWPYSHLEAPVMPIR--TDSDNDRQHARDFARALRQDLVPKLLRLRSCVELDE 589
            .|.:||.....:...:..|....:.::  .:.:.|:..||.|.::| :.|:|:||.|.|..|:|.
Mouse   631 CSLADEEQTPRDYIGHRSLRTAALSLKLLKNQEADQHSARLFIQSL-EGLLPRLLALSSVEEVDS 694

  Fly   590 AMQEFASAVCQENSMNFSDFDYNLT-----AINADGIYLAIYSSLLLSLQLMRAGFYEQ---VAQ 646
            |:|.|||..| ...|:...||...:     .:|||.:|.|.:.:|||:|:|....:|.:   ||.
Mouse   695 ALQNFASTFC-SGMMHSPGFDGGSSLSFQMLMNADSLYTAAHCALLLNLKLSHGDYYRKRPTVAP 758

  Fly   647 GMSHKDILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQSVTVCNVL-----------EAMPRQQ 700
            ||.          ::|:..||.:|||:..|..||.|||..|...|:|           .::|   
Mouse   759 GMM----------KEFMKQVQTSGVLMVFSQAWLEELYHQVLDRNMLGEAGYWGSPEDNSLP--- 810

  Fly   701 LEGMGPRCALVDMLCDAGGLGATQMLSEWQRLQTANVKHKEEEQLHDKRREAAKKLCRRLLTCCW 765
                     |:.||.|..||.::.:..:.....:......:..:|.|. ..|.....|.:|..||
Mouse   811 ---------LITMLTDIDGLESSAIGGQLMASASVESPFTQSRRLDDS-TVAGVAFARYILVGCW 865

  Fly   766 DSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYAMCLDGLHSAATLSNSLNL 830
            .:::..||:.|......|:......|....::   :.|:...:|: .|.||||..||.||.:|.:
Mouse   866 KNLIDTLSTPLTGRMAGSSKGLAFILGAEGIK---EQNQKERDAI-CMSLDGLRKAARLSCALGV 926

  Fly   831 QHLAGKILNLLASNVC--------------------------------QTSGPRISASQAMSMDV 863
            .......|..:|:..|                                :..|..:..:..:.||.
Mouse   927 AANCASALAQMAAASCVQEEKEERQSQEPSDALAQVKLKVEQKLEQMGKVQGVWLHTAHVLCMDA 991

  Fly   864 VLTGGLNLGSYSADCWPSIFAVCRHVSQLEHEIFSMQNPAISASPGSSRRDLET-------GEKL 921
            :|:.||.:||::.||||.:|.||.:|..|||..||   ..||..|.:..:..:|       ||..
Mouse   992 ILSVGLEMGSHNPDCWPHVFRVCEYVGTLEHTHFS---DGISQPPLTIHQPQKTSGSSGLLGEIE 1053

  Fly   922 SNGNAQDKLNLSSIPIDDDETCVDVYSFLQAPMQSPNTNITSILKVYSGTNETV----------- 975
            ...::|:                      |:..|.|:.|...:::.:| ..|.|           
Mouse  1054 FKSSSQE----------------------QSLEQGPSLNTAPVVQPHS-IQELVRECSRGRTSDF 1095

  Fly   976 ---LLSQSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIW 1037
               .||.:..:||:.:||.||:.||.||.::|:|.:|..||..|.:||:.||:.|........:.
Mouse  1096 RGGSLSGNSAAKVVLSLSTQADRLFDDATDKLNLTALGGFLYQLKKASQSQLFHSVTDTVDYSLT 1160

  Fly  1038 WPSKGWKKLDSLPMSLLLHRIGDVTLKVFRS-SRPLLHVLKVWAITGPHLMDAACHRDRMISKRA 1101
            .|.: .|.......:|.|.|:||..|::.|| :||||||::.|::..|||::||||::|.:|::|
Mouse  1161 MPGE-VKSTQDQKSALHLFRLGDAMLRIVRSKARPLLHVMRCWSLVAPHLVEAACHKERHVSQKA 1224

  Fly  1102 IEYIHDIITALLVEQSELPYFHFNEALLKPFENLLSMD-TDVDVQDQIVACLYEVVEAHRTEIRS 1165
            :.:||||:|.:|.:.||.|:|||||||.:|||.::.:: .|.|||||:|..:.|:||....:|:|
Mouse  1225 VSFIHDILTEVLTDWSEPPHFHFNEALFRPFERIMQLELCDEDVQDQVVTSIGELVEVCSAQIQS 1289

  Fly  1166 GWRPLFGTLRNARSRMLNMSN-----------------IIDIFRVFLDSDNTLVFANAGLDCILC 1213
            ||||||..|...||.  |.|.                 :.|:|..||::||..|||||....|:|
Mouse  1290 GWRPLFSALETVRSG--NKSEVKEYLVGDYSMGKGQAPVFDVFEAFLNTDNIQVFANAATSYIMC 1352

  Fly  1214 LLSYLEISGGGNNNA-----CSGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETLRFLERCSSIL 1273
            |:.:  :.|.|..:.     |..|:|:.:                  ||.....|.:|.|||.:|
Mouse  1353 LMKF--VKGLGEVDCKEIGDCVPGAGATS------------------TDLCLPALDYLRRCSQLL 1397

  Fly  1274 GFMHSMPKCPNFHSTYKIKGISYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHIDKD 1338
            ..::.||..|.|.|...           |::|..::..:....|.:::                 
Mouse  1398 AKIYKMPLKPIFLSGRL-----------ASLPRRLQEQSASSEDGIES----------------- 1434

  Fly  1339 TIVKIDEMDKPSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASPGIDFGFYCIN 1403
               .:.:.|..:|:::||.:||:.||.::..||..||.|.|..:|:|.:::..:||..||.|.:.
Mouse  1435 ---VLSDFDDDTGLIEVWIILLEQLTAAVSNCPRQHQPPTLDLLFELLRDVTKTPGPGFGIYAVV 1496

  Fly  1404 HLLVPMIQDWLRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIEKSVPEQRRLGAGTKTRLAQIV 1468
            |||:|::..||...:|..|.|.:...||||...::.:||||.|:                     
Mouse  1497 HLLLPVMSLWLLRSHKDHSYWDVASANFKHAIGLSCELVVEHIQ--------------------- 1540

  Fly  1469 HPADNLLYSKLKFVTERIEREQQQQQSPSVQDHGCGYTQQYDSSSSSASEEQQKNGGGVGGGGSN 1533
                :.|:|.::                            |:|..::                  
Mouse  1541 ----SFLHSDIR----------------------------YESMINT------------------ 1555

  Fly  1534 LIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKHVILSTGMLFNESQWMIACSAI 1598
                          .||.|..:|:.|.|:..|.|:|:..||:::|:::.|.:|.|..|.:||.|:
Mouse  1556 --------------MLKDLFELLVVCVAKPTETISRVGCSCIRYVLVTAGPVFTEEMWRLACCAL 1606

  Fly  1599 HRACTVTIAPLRQLSFAFHEKSNSFYGDCANVKVAARRDS-SLE-ELARIYALAQQVFLSDNQRE 1661
            ..|.:.|:.|::.|...||..:..|.|:...|:|||...| |.| |..||.|:|||||:.|.|..
Mouse  1607 QDAFSATLKPVKDLLGCFHGGTEGFSGEGCQVRVAAPSSSPSAEAEYWRIRAMAQQVFMLDTQCS 1671

  Fly  1662 PGQNQAPTPS----ASQCKL-----SDDRSYSFLLYPLNNGFNSNLDNFVIRIPFKNLVVGLLAN 1717
            |     .||:    |..|:|     .|::.         ||....      .:.|:.:||.||::
Mouse  1672 P-----KTPNNFDHAQSCQLIIELPHDEKP---------NGHAKK------SVSFREIVVSLLSH 1716

  Fly  1718 QMLLQLVAKLLLSRLKCVP--------QAVSTCI--FDNYAASAASPSHDYDLDFRSKEILLRCV 1772
            |:|||.:..:||......|        |...|.:  |..|            :..::..::...:
Mouse  1717 QVLLQNLYDILLEEFVKGPSPGEEKTVQVPDTKLAGFLRY------------ISMQNLAVIFDLL 1769

  Fly  1773 KQYLMSALEFDSRPGLKFLMQKVSNIEYAANLYKQMTSSWMIYYIALVDSHLNDIVVYNLGPEDL 1837
            .....:|.|||:.||||.|::|||.|..|||||:|...|:.||:.|||.:.|.:  ...:..|.:
Mouse  1770 LDSYRTAREFDTSPGLKCLLKKVSGIGGAANLYRQSAMSFNIYFHALVCAVLTN--QETITAEQV 1832

  Fly  1838 NFIL-----------ESCS--------------------------RLNTTTVKKKEN-----FVR 1860
            ..:|           :.||                          ||.:.:|:...|     .|:
Mouse  1833 KKVLFEEEERSSDSSQQCSSEDEDIFEETAQVSPPRGKEKRQWRARLPSLSVQPVSNADWVWLVK 1897

  Fly  1861 YL--FCLQDAWNLVCELYLSNSALH-EIESGSGKLRQKPPQLLHHPQT---KPMCISLNGNGDAE 1919
            .|  .|::     :|..|:.   :| ::||.           |..|.|   .|..|..:...::.
Mouse  1898 RLHKLCME-----LCNHYIQ---MHLDLESS-----------LEEPLTFKSDPFFILPSFQSESS 1943

  Fly  1920 MTDTGSGSGSGSSTSPSKCVQLQEEENV------------------------------------- 1947
            ...||..||..:.:...:...|.|.:::                                     
Mouse  1944 TPSTGGFSGKNTPSEDDRREHLSEPQSLRVGSGDMLMLPPSPKTEKKDPGRKKEWWESAGNKICT 2008

  Fly  1948 -----TMTTLISEFQPKCRSN---PFDTN---------------------------RQAKSSEAE 1977
                 |::.|::|::.:.:.:   ||...                           .|.:...:.
Mouse  2009 MAADKTISKLMTEYKKRRQPHNLPPFPKEVKVDKKGEPLGPRGPDSPLLQRPQHLIDQGQMRHSF 2073

  Fly  1978 SISPEIEQQR--------ASSI---LKDSNYKRAALAQLVVASMELLRSLPGEAEENLKLLMTPT 2031
            |..||:.:|.        .||:   ::|:..:..|...:|:..:..::.||.:....|:..:.|.
Mouse  2074 SAGPELLRQEKRPRSGSTGSSLSVSVRDAEAQIQAWTNMVLTVLNQIQILPDQTFTALQPAVFPC 2138

  Fly  2032 IRE 2034
            |.:
Mouse  2139 ISQ 2141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5937NP_001096888.2 Sec7 451..692 CDD:294092 76/348 (22%)
DUF1981 1115..>1179 CDD:286414 32/64 (50%)
Arfgef3NP_001028430.1 DCB 16..121 CDD:292830 31/107 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..547 5/57 (9%)
Sec7 582..794 CDD:214569 62/223 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..634 6/20 (30%)
DUF1981 1241..>1298 CDD:286414 30/56 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1843..1872 2/28 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1938..1997 6/58 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2058 2/33 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2078..2097 4/18 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 334 1.000 Domainoid score I1127
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41366
Inparanoid 1 1.050 567 1.000 Inparanoid score I1067
Isobase 1 0.950 - 0 Normalized mean entropy S7625
OMA 1 1.010 - - QHG50118
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007013
OrthoInspector 1 1.000 - - oto94971
orthoMCL 1 0.900 - - OOG6_107978
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4037
SonicParanoid 1 1.000 - - X5110
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.850

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