Protein Alignment CG5937 and Y106G6G.2

DIOPT Version :9

• Sequence 1: NP_001096888.2
• Gene: CG5937 / 31537
• FlyBaseID: FBgn0029834
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_001350967.1
• Gene: Y106G6G.2 / 172898
• WormBaseID: WBGene00013711
• Length: 1655
• Species: Caenorhabditis elegans
• Alignment Length: 2138
• Identity: 438/2138 - (20%)
• Similarity: 812/2138 - (37%)
• Gaps: 603/2138 - (28%)

  Fly    14 GT-KHNALRQTAQIAYDKLYRQHGIHRDPSHELRSVCFTALQMALDTKRPKFITMGLNGLHRVIK 77
            || ||:|.::...||.:.|...:.....|...||..|..|.::|.|....|.....::|:..:::
 Worm    10 GTVKHSASKEAINIAKETLKTFNDKKDVPIVHLREKCLAAFELAFDHGNEKHFHHAVDGVQVLLR 74

  Fly    78 DERFY--IGLEPEDDSVWLPSQLLRATNGILPTTSSEDTVVNVLRLFLAMACSPACTLNGRLLIE 140
            |:.::  |..||::.   ||||:|.|..||....|  ......:.|.:.|.||....::
 Worm    75 DQTYHDTITEEPQNS---LPSQVLLAMTGIDEWKS--QLQCKCVTLLVEMVCSNELKVS------ 128

  Fly   141 ILSRCGECWEMGSR--------ATKAASLAAASQCLRTFCAFLIEEAEEVKKTAPAGLMTQTQAS 197
             :|...:|.::..|        ..:.|..||.:|.|..:.:           ...|....|.:|.
 Worm   129 -MSDVEQCVQIYKRLYGKSEEERVRVACRAATTQSLSAYFS-----------NRYAACEAQQEAI 181

  Fly   198 AVYNEVIPVMQWLCSRLVEPNVNASPNKKCENHSSLYLTECILTLSSALPRNVHANPHFTSFLWQ 262
            |||.:|..:::.||:   |....:|.:::|     |...:.|..|.:.....:.::..|.:.||:
 Worm   182 AVYMDVGKLLEELCA---EVEQMSSAHEQC-----LISLDAICALLTTSNLKILSHQPFVNLLWE 238

  Fly   263 KFCPTLAAALGSPGR-INLDKKFTYKDALHMIENEAR-GFFTGPG-LDGPQA-RCVYLTAIQLLR 323
            |.||.:...||.|.: ::...|.:..........|.: .|...|. :..|.. |.:|....||:|
 Worm   239 KVCPLIILLLGIPQKGMSSSSKVSESGGNEEPVGEGQIDFALAPSVITNPYTWRALYQIVDQLIR 303

  Fly   324 IAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCVREIFKSPERLIDLAVILYVDKNTAQGCSDE 388
            :..:..||...||||||:..|.|....|||.|:.:::|.....::..:|......|:
 Worm   304 LMISDPSLASSLEALFHKAFLFPRLDQRTEALKLIKKILGDGSKISKIAKSCVTTKS-------- 360

  Fly   389 MALFRLLVDAMEECAYGASGGGSATEASLQASVECMVALLDSLQVLCSGELTESMISDQIVQVVN 453
            ::|:|:|:..:.||.      ....|.|:.| |:.:||:||.::.|.    |....:||..:::.
 Worm   361 LSLWRMLMTCIAECT------NPQLELSIDA-VKTIVAMLDGMKQLS----THKFFTDQERKLIA 414

  Fly   454 GRHDLLKDADYSGPLTYQSMARLPAPYRDA----IVEFRQTVFETSSGSESEGEPQHEQDAASNG 514
            .....:.|       |..:...|....|.:    :.|..:.||:.|:.|.:
 Worm   415 DTFSCVDD-------TIVNSFSLKCSERVSDICTVDEDTENVFDQSTNSSA-------------- 458

  Fly   515 SGDTEGPEDDDPSSSSDETSRVENRWPYSHLEAPVMPIRT---DSDNDRQHARDFARALRQDL-- 574
                  ||  ||.::  :..::|.::    ..||:...|:   |..::|..|:.|.:||.:.|
 Worm   459 ------PE--DPMAA--KLRKLEQKF----RNAPIATRRSSELDESSERNTAKSFVQALSESLDI 509

  Fly   575 --VPKLLRLRSCVELDEAMQEFASAVCQENSMNFSDFDYNLTA------INADGIYLAIYSSLLL 631
              .||     :.:.:|||:.:|:|.. .||..:.....|...:      :|.|.|||..|:||..
 Worm   510 IAAPK-----NTLSIDEAILQFSSNF-YENFCSVHADAYKSRSKIQQEFLNTDAIYLTAYASLCY 568

  Fly   632 SLQLMRAGFYEQVAQGMSHKDILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQS--VTVCNVLE 694
                            :||.|   ..:.:....:|.::|.:|::::.||.:::.:  :|..||.:
 Worm   569 ----------------ISHPD---TYTLEDLKKTVLHSGCVVHVANGWLDKVFDNLKMTDANVSQ 614

  Fly   695 AMPRQQLEGMGPRCALVDMLCDAGGLGATQMLSEWQRLQTANVKHKEEEQLHDKRREAAKKLCRR 759
            ..|           .|.:::.|..| .|..:||:.::|:....:..|.|...:      |.:.|.
 Worm   615 ITP-----------TLRNVINDFDG-RAKGLLSDVEKLKRIKTRQDEVECTEE------KNVARW 661

  Fly   760 LLTCCWDSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYAMCLDGLHSAATL 824
            :.:..|..::.|||:.|                  .::.|.|..:...||: ::.:.|:.:...:
 Worm   662 MTSSAWQMIIDVLSTFL------------------AVKEKRKTREKIREAI-SVSICGMRNLCAV 707

  Fly   825 SNSLNLQHLAGKILNLLASNVC--------------QTSGPRISASQAMSMDVVLTGGLNLGSYS 875
            :..|.|:...|.|...|....|              :......|....::|.:||... .:..::
 Worm   708 AQVLGLESRCGWIFEQLVETSCCLEDLRDDAIAGDNEQKSTCTSREHLLAMQLVLDEA-RIAIHA 771

  Fly   876 ADCWPSIFAVCRHVSQLEHEIFSMQNPAISASPGSS----RRDLETGEKLSNGNAQDKLNLSSIP 936
            :.||..|.....:|.:||..|:.    |:.....|.    ||..|..|:    :.::|...:...
 Worm   772 SSCWKYIVRCSEYVWELEKYIYG----ALCYEKPSRLKFLRRKTEDKEE----DKEEKTTAADSS 828

  Fly   937 IDD---DETCVDVYSFLQAPMQSPNTNITSILKVYSGTNETVLLSQSDTSKVLCALSHQAENLFG 998
            |::   ||..:.|:|.                                 ::.:|.|..:.:..:.
 Worm   829 IENALGDEPTLSVHSL---------------------------------NRAICVLIAKVDRFYS 860

  Fly   999 DAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIWWPSKGWKKLDSLPMSLLLHRIGDV-- 1061
            .....|.||:    |..||.|.        ::...:|:::.::....| :.|:| ||.||.|:
 Worm   861 KVCRELCLPA----LHDLCVAI--------ISSSENRVFYTAQKHIHL-TAPVS-LLSRISDIIS 911

  Fly  1062 TLKVFRSSRPLLHVLKVWAITGPHLMDAA-CHRDRMISKRAIEYIHDIITALLVEQSELPYFHFN 1125
            ||    |.|||:|.:.::.:...|.:..: |.::..|:..|:.   :::|.|||  ||.|...||
 Worm   912 TL----SHRPLVHQMFIYPLVSAHFVKVSQCDQESRIAASALA---EVVTRLLV--SESPGMSFN 967

  Fly  1126 EALLKPFENL-LSMDTDVDVQDQIVACLYEVVEAHRTEIRSGWRPLFGTLR---NARSRMLNMSN 1186
            :.|:.||:.. .|.:...:.::|.::.|.::|::...:|.|||:||||:|:   .||...::..
 Worm   968 QTLIGPFQTASCSENCSEETKEQFLSSLSQLVQSQADKIGSGWKPLFGSLKAVGAARDEKVHWC- 1031

  Fly  1187 IIDIFRVFLDSDNTLVFANAGLDCILCLLSYLEISGGGNNNACSGGSGSAAGGTASNGGQQEEDN 1251
            .||:...:|..|:..|.:::.|:|:.|:::.|:      |:..|....|||
 Worm  1032 AIDVISSYLRIDSPPVLSSSILECVPCVVNLLQ------NSEDSSEVSSAA-------------- 1076

  Fly  1252 TFRPTDFLHETLRFLERCSSILGFMHSMPKCPNFHSTYKIKGISYTHIIDANIPSSMENFTYFGN 1316
                       ||.|....|::.:::|.|..||:|
 Worm  1077 -----------LRLLPNIYSLILYLYSTPHVPNYH------------------------------ 1100

  Fly  1317 DYLQTRNEQYMISYRSLHIDKDTIVKIDEMDKPSGV-------------LKVWFLLLDGLTNSLI 1368
              |..|::.......::.:|:|.|      :.|.|.             ::::...::.:..:|:
 Worm  1101 --LLHRSDLRSKCLDTVEMDQDPI------EVPHGPFPWNEKQTYEIAGVELFLTFMEQICGTLL 1157

  Fly  1369 VCPYSHQAPILQTIFKLFKNLLASP-GIDFGFYCINHLLVPMIQDWLRYINKTGSSWQLVEKNFK 1432
            ....:.|..:|..|.:|..::...| |.|.|..|::.:::|.:|.|:|.::        ||:
 Worm  1158 TSSPNTQKNLLDMIGRLLVDISTKPLGADSGGVCMSAVILPYVQKWIRRLD--------VEE--- 1211

  Fly  1433 HCCCMTTDLVVEFIEKSVPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTERIEREQQQQQSPS 1497
                      |:.:::.:      ||.|:|                   |.:.:|.|:..    |
 Worm  1212 ----------VKILKQVI------GACTQT-------------------VIDMLELEKMS----S 1237

  Fly  1498 VQDHGCGYTQQYDSSSSSASEEQQKNGGGVGGGGSNLIESPTKISGSATLALKQLLLVLIECAAQ 1562
            .||.                                              .|:.:..:::||...
 Worm  1238 WQDR----------------------------------------------LLRDICALIVECVLF 1256

  Fly  1563 SQE-AIARISVSCLKHVILSTGMLFNESQWMIACSAIHRACTVTIAPLRQLSFAFHEKSNSFYGD 1626
            .:. |:|....:    :|......|:..||.|..:.:..|.|.::..:|.|:..|...|....||
 Worm  1257 DKTCAVAPAYFT----LIAMNSSKFSTQQWNIFSNFLATASTQSLRHVRLLNSFFVRSSTDENGD 1317

  Fly  1627 CANV------KVAARRDSSLEELARIYALAQQVFLSDNQREPGQNQAPTPSASQCKLSDDRSYSF 1685
            ..:|      |:..|:          ...|.||..|..::..||           |..:|.|...
 Worm  1318 IGDVTSYNPGKLTFRQ----------LIAAVQVLSSQKEKSLGQ-----------KEEEDLSSGV 1361

  Fly  1686 LLYPLNNGFNSNLDNFVIRIPFKNLVVGLLANQMLLQLVAKLLLSRLKCVPQAVSTCIFDNYAAS 1750
            .|..|::|.:::      |:...:::..|..:.:||||:|.||||. ...|:..:|.|      .
 Worm  1362 ALIMLSHGADTH------RLEVHSIISSLFTHCLLLQLIASLLLSE-DSNPKLKATLI------G 1413

  Fly  1751 AASPSHDYDLDFRSKEILLRCVKQYLMSALEFDSRPGLKFLMQKVSNIEYAANLYKQMTSSWMIY 1815
            :.||. |..||.....||...:.:...::|:|||||.:..|:.::..|:: |||.|.:.||.:..
 Worm  1414 STSPI-DPKLDDSIYPILYNILNESSETSLDFDSRPAVGSLLSRMLGIKH-ANLLKALVSSNLTK 1476

  Fly  1816 YIALV---DSHLNDIVVYNLGPE----------DLNFILESCSRLNTTTVKKKENFVRYLFCLQD 1867
            .::|:   :...|.    .|.||          ||..:....|...:..|.::....:|.....|
 Worm  1477 TMSLLRRFEKTKNT----ELLPEIAKAVKSRSVDLKSVEFEVSTRRSAFVTREHAITQYHLVPVD 1537

  Fly  1868 -----AWNLVCELYLSNSALHEIESGSGKLRQKPPQLLHHPQTKPMCISLNGNGDAEMTDTGSGS 1927
                 |:.||.:.:: :.||.|.:.             |..:.||
 Worm  1538 NGEENAYKLVSQEFV-DGALSEYDK-------------HRDRLKP-------------------- 1568

  Fly  1928 GSGSSTSPSKCVQLQEEENVTMTTLISEFQPKCRSNPFDTNRQAKSSEAESISPEIEQQRASSIL 1992
                                        |.|. |.|||    |....:::::|.:.:.:....|
 Worm  1569 ----------------------------FIPD-RRNPF----QHAIDDSDTVSIDSKTEDFDEI- 1599

  Fly  1993 KDSNYKRAALAQLVVASMELLRSLPGEAEENLKLLMTPTIREAFRLVQLQGNELKVNQ 2050
            :.:.|:...|..|...|..|||       |:|...:.|..:     :.|...:|.|.|
 Worm  1600 RLAAYRDICLIPLRYVSDNLLR-------EHLPDFLPPVTQ-----IVLSSPDLAVRQ 1645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	51/259 (20%)
		DUF1981	1115..>1179	CDD:286414	22/67 (33%)
Y106G6G.2	NP_001350967.1	Sec7	408..609	CDD:214569	51/260 (20%)
		DUF1981	960..1038	CDD:370432	24/78 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I3215
eggNOG	1	0.900	-	-		E1_KOG1846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41366
Inparanoid	1	1.050	250	1.000	Inparanoid score	I2004
Isobase	1	0.950	-	0	Normalized mean entropy	S7625
OMA	1	1.010	-	-		QHG50118
OrthoDB	1	1.010	-	-		D27409at33208
OrthoFinder	1	1.000	-	-		FOG0007013
OrthoInspector	1	1.000	-	-		oto19998
orthoMCL	1	0.900	-	-		OOG6_107978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4037
SonicParanoid	1	1.000	-	-		X5110
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.760