DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5937 and AgaP_AGAP000635

DIOPT Version :9

Sequence 1:	NP_001096888.2	Gene:	CG5937 / 31537	FlyBaseID:	FBgn0029834	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_311163.5	Gene:	AgaP_AGAP000635 / 1272414	VectorBaseID:	AGAP000635	Length:	2124	Species:	Anopheles gambiae

Alignment Length:	2178	Identity:	1250/2178 - (57%)
Similarity:	1539/2178 - (70%)	Gaps:	204/2178 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDLFLLIIKESTGTKHNALRQTAQIAYDKLYRQHGIHRDPSHELRSVCFTALQMALDTKRPKFI 65
            ||:|.:.|:||:||:|...|:|.||||::||.||||:|||||:||||||||||||||:|||||||
Mosquito     1 MEELLMSIVKEATGSKLQNLKQAAQIAHEKLSRQHGMHRDPSYELRSVCFTALQMALETKRPKFI 65

  Fly    66 TMGLNGLHRVIKDERFYIGLEPEDDSVWLPSQLLRATNGILPTTSSEDTVVNVLRLFLAMACSPA 130
            |.|||||||:|:||||:.||||||||:|||:||||||:. |.:.::||||||||||.||||||..
Mosquito    66 TYGLNGLHRIIRDERFFTGLEPEDDSLWLPAQLLRATSS-LSSIANEDTVVNVLRLILAMACSQT 129

  Fly   131 CTLNGRLLIEILSRCGECWEMGSRATKAASLAAASQCLRTFCAFLIEEAEEVKKTAPAGLMTQTQ 195
            ||||||||||:||:||||||.||||.|||||||.|||||||||||.:||||:.:..|.|:::...
Mosquito   130 CTLNGRLLIEMLSKCGECWENGSRAVKAASLAAGSQCLRTFCAFLKDEAEEIVRLDPTGIISLGM 194

  Fly   196 ASAVYNEVIPVMQWLCSRLVEPNVNA-------SPNKKCENHSSLYLTECILTLSSALPRNVHAN 253
            |:||||||||||||||||||||...:       :||      |||||.||||||..:||.:||||
Mosquito   195 AAAVYNEVIPVMQWLCSRLVEPATGSTKAGDGGTPN------SSLYLMECILTLVVSLPSDVHAN 253

  Fly   254 PHFTSFLWQKFCPTLAAALGSPGRINLDKKFTYK---------------------DALHMIENEA 297
            ||||:||||||||||||.:|||||:|.||||||:                     ||:|:||:|.
Mosquito   254 PHFTAFLWQKFCPTLAATMGSPGRVNKDKKFTYRGGRTQELQGVRWIVSSACNSCDAIHLIESEN 318

  Fly   298 RGFFTGPGLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCVREIF 362
            |||||.||||||||||:|||:|||||||||.||||||||||||||||||.|.||.||||..||||
Mosquito   319 RGFFTRPGLDGPQARCIYLTSIQLLRIAGAQGSLRPMLEALFHRMLLLPVPSNRAEPLRYAREIF 383

  Fly   363 KSPERLIDLAVILYVDKNTAQGCSDEMALFRLLVDAMEECAYGASGGGSATEASLQASVECMVAL 427
            ||||||||||:|||.||  .|..||:||||||::|||||||.....|.::...:|.:||||:|||
Mosquito   384 KSPERLIDLAIILYPDK--TQSSSDDMALFRLVIDAMEECAAAWHHGSASVYGALSSSVECVVAL 446

  Fly   428 LDSLQVLCSGELTESMISDQIVQVVNGRHDLLKDADYSGPLTYQSMARLPAPYRDAIVEFRQTVF 492
            |:|||||.||...||:|.|:|.::||.|:..|.||||:||||||||.|||.|||||:.|.||:.|
Mosquito   447 LESLQVLSSGSYDESLIGDRIAELVNERYAALADADYTGPLTYQSMTRLPPPYRDAVAELRQSGF 511

  Fly   493 ETSSGSESEGEPQH---EQDAASNGSGDTEGPEDDDPSSSSDETSRV-ENRWPYSHLEAPVMPIR 553
            |:||.|:::|..:.   :.:..|.||||||||||:..||..|.:|:. :..|.::|::......|
Mosquito   512 ESSSESDADGPLEQGTIDPELGSVGSGDTEGPEDETHSSGDDVSSKASQGNWLWAHIDDSGSSGR 576

  Fly   554 TDSDNDRQHARDFARALRQDLVPKLLRLRSCVELDEAMQEFASAVCQENSMNFSDFDYN-LTAIN 617
            :|.|.||||||:||..|..:|||.||||::.:|:|||:|||||.|||.||....|.||. |||:|
Mosquito   577 SDGDCDRQHAREFAAVLASELVPSLLRLKTSIEIDEAVQEFASRVCQRNSATRGDGDYGALTALN 641

  Fly   618 ADGIYLAIYSSLLLSLQLMRAGFYEQVAQGM---SHKDILVPMSEQQFVTSVQNTGVLVYLSSPW 679
            |||||||.||:|||:|||:..|.|::...|:   ..|...:|::||||||||||:|:|||||:.|
Mosquito   642 ADGIYLATYSALLLALQLVTGGHYDEDGGGIDTDGPKPAAIPLTEQQFVTSVQNSGILVYLSAAW 706

  Fly   680 LCELYQSVTVCNVLEAM---PRQQLEGMGPRCALVDMLCDAGGLGATQMLSEWQRLQTANVKHKE 741
            |.||||.:...|.|:|:   .|.:.......|||:|||.||||.|.|||||:|||||:....|.|
Mosquito   707 LRELYQCILAGNPLQALTATQRAKDPAASSHCALLDMLHDAGGTGPTQMLSDWQRLQSVVRVHTE 771

  Fly   742 EEQLHDKRREAAKKLCRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSN 806
            .    ..::.||:|:.||||||||||||.||::|||:.. .|.:.:||.|||:||||: |..:.:
Mosquito   772 P----TAKQRAARKIARRLLTCCWDSMVAVLTAGLGEAD-GSPTARLVKLSKKTLRVR-KETRGS 830

  Fly   807 GEALYAMCLDGLHSAATLSNSLNLQHLAGKILNLLASNVCQTSGPRISASQAMSMDVVLTGGLNL 871
            ||.|||:.|||||:||||||:|:||||||||:||:||||||.:||:|.||.|:||||||:|||.|
Mosquito   831 GETLYALSLDGLHAAATLSNALSLQHLAGKIINLIASNVCQNAGPKIPASHALSMDVVLSGGLEL 895

  Fly   872 GSYSADCWPSIFAVCRHVSQLEHEIFSMQNPA--ISASPGSSRRDLETGEKLSNGNAQ-DKLNLS 933
            ||:|||||..:|:|||||:||||::||.|:.|  :..:||..:....:.::...|..| |:|:||
Mosquito   896 GSHSADCWLPVFSVCRHVTQLEHDLFSSQSNATNVGNAPGVGQCKESSDQQFGKGETQSDRLHLS 960

  Fly   934 SIPIDDDETCVDVYSFLQAPMQSPNTNITSILKVYSGTNETVLLSQSDTSKVLCALSHQAENLFG 998
            ...:|:||||||||||||||..:.|.|:.:|||.|| .|:.|.|:|:||:|:||||||||:.||.
Mosquito   961 PYSVDEDETCVDVYSFLQAPNTNANINVITILKAYS-ANDAVNLTQTDTAKMLCALSHQADVLFA 1024

  Fly   999 DAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIWWPSKGWK-KLDSLPMSLLLHRIGDVT 1062
            :||||||||:|.|||:.||||||:|||:|...:||.:.||..:.|| |.||||:||||||:||||
Mosquito  1025 EAAERLSLPALQQFLRSLCRASREQLYRSTSLKKGKKSWWLGRPWKVKNDSLPLSLLLHRVGDVT 1089

  Fly  1063 LKVFRSSRPLLHVLKVWAITGPHLMDAACHRDRMISKRAIEYIHDIITALLVEQSELPYFHFNEA 1127
            |||||..|||||||||||||||||||||||:||.||||||||||||||||||||:|||:||||||
Mosquito  1090 LKVFRGPRPLLHVLKVWAITGPHLMDAACHKDRSISKRAIEYIHDIITALLVEQTELPHFHFNEA 1154

  Fly  1128 LLKPFENLLSMDT-DVDVQDQIVACLYEVVEAHRTEIRSGWRPLFGTLRNARSRMLNMSNIIDIF 1191
            ||||||||||||: |:||||||||||||:||||||||||||||||||||.||:|.:::|||||||
Mosquito  1155 LLKPFENLLSMDSCDIDVQDQIVACLYEIVEAHRTEIRSGWRPLFGTLRTARNRPVHLSNIIDIF 1219

  Fly  1192 RVFLDSDNTLVFANAGLDCILCLLSYLEISGGGNNNACSGGSGSAAGGTASNGGQQEEDNTFRPT 1256
            ||||::||.||||||||||||||||||||||.|...|...|...||...|   |..:...|.|..
Mosquito  1220 RVFLETDNMLVFANAGLDCILCLLSYLEISGNGPAAAADHGQYPAAAAAA---GTDDLSLTMRSG 1281

  Fly  1257 DFLHETLRFLERCSSILGFMHSMPKCPNFHSTYKIKGISYTHIIDANIPSSMENFTYFGNDYLQT 1321
            |||::.|:|||||:|||.||::||:|||.|||||||||:||||||||||:||||||:||.:|||:
Mosquito  1282 DFLYDALKFLERCASILDFMYNMPQCPNLHSTYKIKGITYTHIIDANIPNSMENFTFFGQEYLQS 1346

  Fly  1322 RNEQYMISYRSLHIDKDTIVKIDEMDKPSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLF 1386
            .|||.|||||||||||::|.||||:|:|||||||||||||||||||||||.:||:||||:|||||
Mosquito  1347 TNEQCMISYRSLHIDKESIRKIDELDRPSGVLKVWFLLLDGLTNSLIVCPIAHQSPILQSIFKLF 1411

  Fly  1387 KNLLASPGIDFGFYCINHLLVPMIQDWLRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIEKSVP 1451
            |.|:.|||::||||||||||:|||||||||:||...||.|:||||||||||||||||:|:.||
Mosquito  1412 KTLMISPGVEFGFYCINHLLIPMIQDWLRYVNKAQKSWVLIEKNFKHCCCMTTDLVVDFLAKS-- 1474

  Fly  1452 EQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTERIEREQQQQQSPS---VQDHGCGYTQQYDSSS 1513
                  ...:|...::|..:::||              .|...|||   ......|...:|..:.
Mosquito  1475 ------QTLETLGDRVVIGSESLL--------------GQSTPSPSSARAATRAAGSDGKYRKTP 1519

  Fly  1514 SSASEEQQKNGGGVGGGGSNLIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKHV 1578
            .:..|..       ||..|..:..|:    ||.|||||||||||||:|||||.|||:.|||:|||
Mosquito  1520 HTGDEPP-------GGKASGTLRLPS----SAVLALKQLLLVLIECSAQSQETIARVGVSCMKHV 1573

  Fly  1579 ILSTGMLFNESQWMIACSAIHRACTVTIAPLRQLSFAFHEKSNSFYGDCANVKVAARRDSSLEEL 1643
            |.|.|.||.|.||:|..||||||.||::|||:||.|||:..|||||||||||||||||||:.|||
Mosquito  1574 IFSAGYLFEEEQWVIIASAIHRASTVSMAPLKQLIFAFNRNSNSFYGDCANVKVAARRDSTPEEL 1638

  Fly  1644 ARIYALAQQVFLSDNQREP-GQNQAPTPSASQCKLSDDRSYSFLLYPLN-NG------------- 1693
            .||::|||||||.|.||:. |....|.|       .:|||||||||||. ||
Mosquito  1639 QRIHSLAQQVFLMDTQRDALGGRSLPVP-------QEDRSYSFLLYPLQCNGAALSSPVSGAGGS 1696

  Fly  1694 ---------FNSNLDNFVIRIPFKNLVVGLLANQMLLQLVAKLLLSRLKCVPQAVSTCIFDNYAA 1749
                     :...:|.::||||::||:||:||:||||||:|.:|||.|..||..::||.:.: .|
Mosquito  1697 SLSTGMPPSYGLAVDCYIIRIPYRNLIVGMLASQMLLQLIANILLSGLSNVPSELNTCFYSS-GA 1760

  Fly  1750 SAASPS----HD--------YDLDFRSKEILLRCVKQYLMSALEFDSRPGLKFLMQKVSNIEYAA 1802
            .|..|.    |.        :.|...|||||||.::|:|:.|:|||:|||||||:||||.|:|||
Mosquito  1761 EAGPPGGATPHSVAGGSKTLFYLGQNSKEILLRALRQFLIGAVEFDTRPGLKFLIQKVSGIDYAA 1825

  Fly  1803 NLYKQMTSSWMIYYIALVDSHLNDIVVYNLGPEDLNFILESCS---RLNTTTVKKKENFVRYLFC 1864
            ||||||.|||:|:|:||||.:||::.:::|..||:.::|.||.   .......|..|..:.|||.
Mosquito  1826 NLYKQMNSSWIIHYMALVDMYLNNVRIHSLTAEDVRYLLSSCCDQYAAGPHPAKGDEKCIHYLFA 1890

  Fly  1865 LQDAWNLVCE-----------------LY-------LSNSALHEIESGSGKLRQKPPQLLHH--P 1903
            |:|.|.::.:                 ||       |..:|.|....|.      |..:|:|  .
Mosquito  1891 LRDLWEMIADHFIQHLESDRERSRKAHLYAEAADEPLERAAEHREHGGD------PGTILYHYPD 1949

  Fly  1904 QTKPMC-------ISLNGNGDAEMTDTGSGSGSGSSTS---PSKCVQLQEEENVTMT--TLISEF 1956
            |....|       ...||||..:....|....:.:..|   |.:...|......|..  ....:|
Mosquito  1950 QAADDCGQPPAALRQSNGNGARKAAGDGETLAAAARRSLPHPHQPYYLPAANGPTAAGQEPAKDF 2014

  Fly  1957 QPKCRSNPF------DTNRQAKSSE--------AESISPEIEQQRASSILKDSNYKRAALAQLVV 2007
            :|..:..|.      ..:|.|...|        .::|.||||||||.||.||.:||.:||.||:|
Mosquito  2015 EPVYQQQPEPPAEQPPAHRSATKGEHPTEGERQKQTIPPEIEQQRALSIQKDVSYKTSALRQLIV 2079

  Fly  2008 ASMELLRSLPGEAEENLKLLMTPTIREAFRLVQ 2040
            ||:||::.||||..|.|:||:||.|||||..|:
Mosquito  2080 ASIELIKLLPGEQSEFLQLLLTPRIREAFHFVE 2112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	132/248 (53%)
CG5937	NP_001096888.2	DUF1981	1115..>1179	CDD:286414	57/64 (89%)
AgaP_AGAP000635	XP_311163.5	Sec7	534..714	CDD:294092	99/179 (55%)
AgaP_AGAP000635	XP_311163.5	DUF1981	1142..>1207	CDD:286414	57/64 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	1390	1.000	Domainoid score	I57
eggNOG	1	0.900	-	-		E1_KOG1846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41366
Inparanoid	1	1.050	2302	1.000	Inparanoid score	I120
OMA	1	1.010	-	-		QHG50118
OrthoDB	1	1.010	-	-		D27409at33208
OrthoFinder	1	1.000	-	-		FOG0007013
OrthoInspector	1	1.000	-	-		oto110874
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5110
TreeFam	1	0.960	-	-
	13	12.940