DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5937 and ARFGEF1

DIOPT Version :9

Sequence 1:NP_001096888.2 Gene:CG5937 / 31537 FlyBaseID:FBgn0029834 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_006412.2 Gene:ARFGEF1 / 10565 HGNCID:15772 Length:1849 Species:Homo sapiens


Alignment Length:1863 Identity:317/1863 - (17%)
Similarity:594/1863 - (31%) Gaps:645/1863 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 TAPAGLMTQTQASAVYNEVIP-----VMQWLCSRLVEPNVNASPNKKC-ENHSSLYLTECILTLS 243
            |..:|..:.....|.::.::.     |.:.||...::|..:..|:.|. |..|.:...:.:|::.
Human   400 TQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSIL 464

  Fly   244 SALPRNVHANPHFTSFLWQKFCPTLAAALGSPGRINLDKKFTYKDALHMIENEARGFFTGPGLDG 308
            .........|..|.:.:.|..|    .||...|..::.:.|..                      
Human   465 QNAGPIFRTNEMFINAIKQYLC----VALSKNGVSSVPEVFEL---------------------- 503

  Fly   309 PQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLL------LPAPQNRTEPLRCVREIFKSPER 367
              :..::||   ||.....|  |:..:|..|..:.|      ..:..::...::.:..|....:.
Human   504 --SLSIFLT---LLSNFKTH--LKMQIEVFFKEIFLYILETSTSSFDHKWMVIQTLTRICADAQS 561

  Fly   368 LIDLAVILYVDKNTAQGCSDEMALFRLLVDAMEECAYGAS----GGGSATEASL-QASVECMVAL 427
            ::|:.|....|.|.|.       :|..||:.:.:.|.|..    |..:..|.|| :..:||:|::
Human   562 VVDIYVNYDCDLNAAN-------IFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSI 619

  Fly   428 LDSLQVLCSGELTESMISDQIVQVVNGRHDLLKDADYSGPLTYQSMARLPAPYRDAIVEFRQTVF 492
            |.     |..|.::....:...|...|:.   |.::       |.|:.:..|         :|:.
Human   620 LK-----CMVEWSKDQYVNPNSQTTLGQE---KPSE-------QEMSEIKHP---------ETIN 660

  Fly   493 ETSSGSESEGEPQHEQDAASNGSGDTEGPEDDDPSSSSDETSRVE------NRWP---------- 541
            ...|.:..|........:.|.....|:.||..:......|.  :|      |:.|          
Human   661 RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEI--IEQGIDLFNKKPKRGIQYLQEQ 723

  Fly   542 ------------YSHLEAPVMPIRTDS--------DNDR-----------QH---ARDFARALRQ 572
                        :.|.|.     |.||        |||:           ||   .:||..|||.
Human   724 GMLGTTPEDIAQFLHQEE-----RLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRM 783

  Fly   573 DLVPKLLRL-RSCVELDEAMQEFASAV--CQENSMNFSDFDYNLTAINADGIYLAIYSSLLLSLQ 634
            .|  :..|| ....::|..|::||:..  |.:....|:         :||..|:..||.::|:..
Human   784 FL--EGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFA---------SADTAYVLAYSIIMLTTD 837

  Fly   635 LMRAGFYEQVAQGMSHK-DILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQSVTVCNVLEAMPR 698
            |              |. .:...|:::|::.  .|.|:                   |..:.:|.
Human   838 L--------------HSPQVKNKMTKEQYIK--MNRGI-------------------NDSKDLPE 867

  Fly   699 QQLEGM-----GPRCALVDMLCDAGGLGATQMLSEWQRLQTANVKHKEEEQL-----HDKRREAA 753
            :.|..:     |.:.::.:          |:.|:...:....||..:::.:|     .::..:.|
Human   868 EYLSAIYNEIAGKKISMKE----------TKELTIPTKSSKQNVASEKQRRLLYNLEMEQMAKTA 922

  Fly   754 KKL-------------------CRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVK 799
            |.|                   .|.:....|...:...|.||.|...:..:              
Human   923 KALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVA-------------- 973

  Fly   800 AKANKSNGEALYAMCLDGLHSAATLSNSLNLQHLAGKILNLLASNVCQTSGPRISASQAMSMDVV 864
                        ::||:|:..|..::...::|......:..||.....|....|:..:..::|.:
Human   974 ------------SLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTI 1026

  Fly   865 ---LTGGLNLGSYSADCWPSIFAVCRHVSQLE--HEIFSMQNPAISASPGSSRRDLETGEK---- 920
               :|.....|:|..:.|..|.   :.:||||  ..|.:...|...:.....|....||.|    
Human  1027 KTLITVAHTDGNYLGNSWHEIL---KCISQLELAQLIGTGVKPRYISGTVRGREGSLTGTKDQAP 1088

  Fly   921 -------LSNGNAQDKLNLSSIPIDDDETCVDVYSFLQAPMQSPNTNITSILKVYSGTNETVLLS 978
                   |..||. |...::||.....||             |..:.:.::.::::|:.      
Human  1089 DEFVGLGLVGGNV-DWKQIASIQESIGET-------------SSQSVVVAVDRIFTGST------ 1133

  Fly   979 QSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIWWPSKGW 1043
                                    ||...::..|::.||..|.|:|..:                
Human  1134 ------------------------RLDGNAIVDFVRWLCAVSMDELLST---------------- 1158

  Fly  1044 KKLDSLPMSLLLHRIGDVTLKVFRSSRPLLHVLKVWAITGPHLMDAACHRDRMISKRAIEYIHDI 1108
                :.|....|.:|  |.:..:...|..|...::|.:.|.|.....|:.:..::..|::.:..:
Human  1159 ----THPRMFSLQKI--VEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQL 1217

  Fly  1109 ITALLVEQSELPYFHFNEALLKPFENLLSMDTDVDVQDQIVACLYEVVEAHRTEIRSGWRPLFGT 1173
            ....| |:.||..|.|.:..|:|||:::..:....::|.:|.|:.::|.:....|||||:.:|..
Human  1218 SMKFL-EKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSV 1281

  Fly  1174 LRNARSRMLNMSNIIDIFRVFLDSDN--TLVF-------ANAGLDCILCLLSYLEISGGGNNNAC 1229
            ...|.|.  ...:|:::  .|..:.:  ||||       .::..|.:.||..:          ||
Human  1282 FHLAASD--QDESIVEL--AFQTTGHIVTLVFEKHFPATIDSFQDAVKCLSEF----------AC 1332

  Fly  1230 SGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETLRFLERCSSILGFMHSMPKCPNFHSTYKIKGI 1294
            :.                    .|..|..  |.:|.:..|:..:                     
Human  1333 NA--------------------AFPDTSM--EAIRLIRHCAKYV--------------------- 1354

  Fly  1295 SYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHIDKDTIVKIDEMDKPSGVLKVWFLL 1359
                   ::.|.:.:.:|   :|.:....|..:                        .::.||.:
Human  1355 -------SDRPQAFKEYT---SDDMNVAPEDRV------------------------WVRGWFPI 1385

  Fly  1360 LDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASPGIDFGFYCINHLLVPMIQDWLRYINKTGSSW 1424
            |..|:..:..|....:...|..:|::.|.        :|.....|    ..||..|.:.:...:.
Human  1386 LFELSCIINRCKLDVRTRGLTVMFEIMKT--------YGHTYEKH----WWQDLFRIVFRIFDNM 1438

  Fly  1425 QLVEKNFKHCCCMTTDLVVEFIEKSVPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTERIERE 1489
            :|.|:..:....|||                              ..::.||:.           
Human  1439 KLPEQQTEKAEWMTT------------------------------TCNHALYAI----------- 1462

  Fly  1490 QQQQQSPSVQDHGCGYTQQYDSSSSSASEEQQKNGGGVGGGGSNLIESPTKISGSATLALKQLLL 1554
                         |....||                               :...:.:.|..:..
Human  1463 -------------CDVFTQY-------------------------------LEVLSDVLLDDIFA 1483

  Fly  1555 VLIECAAQSQEAIARISVSCLKHVILSTGMLFNESQWMIACSAIHRACTV----TIAPLRQLSFA 1615
            .|..|..|..|.:||...:||::|::..|..|....|...|:     ||:    |..|...|:: 
Human  1484 QLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCN-----CTLDIFKTTIPHALLTW- 1542

  Fly  1616 FHEKSNSFYGDCANVKVAARRDSSLEELARIYALAQQVFLSDN---QREPGQNQAPTPSASQCKL 1677
               :.||  |:.|....:...:..|:.:::     :.|.:.|:   :....:.|||..|||    
Human  1543 ---RPNS--GETAPPPPSPVSEKPLDTISQ-----KSVDIHDSIQPRSVDNRPQAPLVSAS---- 1593

  Fly  1678 SDDRSYSFLLYPLNNGFNSNLDNF--VIRIPFKNLVVGLLANQMLLQLVAKLLLSRLKCVPQAVS 1740
                           ..|..:...  ..:.|.:.|...||                :|||.|...
Human  1594 ---------------AVNEEVSKIKSTAKFPEQKLFAALL----------------IKCVVQLEL 1627

  Fly  1741 TCIFDNY-----------AASAASPSHD-YDLDFR-------------SKEI--LLRCVKQYLMS 1778
            ....||.           |.:.|:...| .|.|.|             |:::  ||.|:.:....
Human  1628 IQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLFKLLDCLLESHRF 1692

  Fly  1779 ALEFDSRPGLKFLMQKVS-NIEYAANLYKQMTSSW-----MIYYIALVDSHLN--DIVVYNLGPE 1835
            |..|:|....:..:.|.. ..:...||.||.|||.     :::.:.:.:|.::  :.|...|   
Human  1693 AKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRL--- 1754

  Fly  1836 DLNFILESCSRLNTTTVKKKENFVRYLFCLQDAWNLVCELYLS 1878
             ||...|:.|...|.|.:..          ::||..:..|:|:
Human  1755 -LNVCSEALSYFLTLTSESH----------REAWTNLLLLFLT 1786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5937NP_001096888.2 Sec7 451..692 CDD:294092 52/294 (18%)
DUF1981 1115..>1179 CDD:286414 20/63 (32%)
ARFGEF1NP_006412.2 DCB, DCB:DCB domain and DCB:HUS domain interaction 2..224
PLN03076 15..1766 CDD:215560 311/1831 (17%)
DCB 29..210 CDD:292830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..248
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..413 2/12 (17%)
Sec7_N 419..573 CDD:289549 29/186 (16%)
HUS, DCB:HUS domain interaction 557..577 4/19 (21%)
Sec7 698..882 CDD:279680 44/236 (19%)
Nuclear localization signal (NLS) 711..715 1/3 (33%)
DUF1981 1220..1301 CDD:286414 24/85 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1562 4/20 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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