Protein Alignment CG5937 and arfgef3

DIOPT Version :9

• Sequence 1: NP_001096888.2
• Gene: CG5937 / 31537
• FlyBaseID: FBgn0029834
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_031758024.1
• Gene: arfgef3 / 101734636
• -ID: -
• Length: 2152
• Species: Xenopus tropicalis
• Alignment Length: 2315
• Identity: 600/2315 - (25%)
• Similarity: 968/2315 - (41%)
• Gaps: 553/2315 - (23%)

  Fly     1 MEDLFLLIIKESTGTKHNALRQTAQIAYDKLYRQHGIHRDPSHELRSVCFTALQMALDTKRPKFI 65
            ||::...:.||:||.|:.|::.....:.:.|.....:.:...::||..|...||:||::|..|..
 Frog     1 MEEILRKLQKEATGNKYKAIKDKCTGSIEILETPESLSKILPYQLREKCLLPLQLALESKNVKLA 65

  Fly    66 TMGLNGLHRVIKDERFYIGLEPEDDSVWLPSQLLRATNGILPTTSSEDTVVNVLRLFLAMACSPA 130
            ...|.|:.:::.|:|| :.:|.:.|...|.:|:|.|.. :.|:. .||..|.|:::.|.:..:..
 Frog    66 QHALAGMQKMLADDRF-VSVEKDRDEHQLLNQMLNAVK-VTPSL-HEDLQVEVMKVLLCITYTST 127

  Fly   131 CTLNGRLLIEILSRCGECW--EMGSRATKAASLAAASQCLRTFCAFLIEEAE------------- 180
            ..|||..:::|...|.|.:  ....|:...|..|..||.|......|.::.|
 Frog   128 FELNGISVLKIAEICIETYVSSCHKRSINTAIRATLSQMLGDLTLQLCQKQECQNVENHEALLEF 192

  Fly   181 EVKKTAPAGLMTQTQASAVYNEVIPVMQWLCSRLVEPNVNASPNKKCENH--SSLYLTECILTLS 243
            ..|:..|:       ...:.::::.|...||.:| :..:|       |||  ..||| ||||::.
 Frog   193 RSKEMGPS-------VEFLCDDIVSVFTVLCDKL-QAVIN-------ENHPLQLLYL-ECILSVL 241

  Fly   244 SALPRNVHANPHFTSFLWQKFCPTLAAALGSPGRINLDKKFTYKDALHM------------IENE 296
            ::....:|.:..||..:|::.||.|...||:|..   ||..|   :.|.            :.::
 Frog   242 NSSSPEIHHHKGFTDLIWKQLCPALVVILGNPVH---DKTVT---SAHNNFCIDSDCQSAGVADQ 300

  Fly   297 ARG---FFTGPGLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLLLPAPQNRTEPLRCV 358
            .||   ..|.|.|.||.||.:|..|.:|:|:.|...|:||:|::|:||:||...||||.|.::.:
 Frog   301 GRGSACSSTAPALSGPSARAIYYIAAELVRLIGTVDSMRPVLQSLYHRILLYAPPQNRVESIKIM 365

  Fly   359 REIFKSPERLIDLAVILYVDKNTAQGC----SDEMALFRLLVDAMEECAYGASGGGSATEASLQA 419
            :||...|:||.|||....::..|.:..    ...:.|.:|::|.|.|   |...||  .||.. |
 Frog   366 KEILSRPQRLFDLAGPCRLESETKKRSILKRKSHLDLLKLIMDGMTE---GCFKGG--IEACF-A 424

  Fly   420 SVECMVALLDSLQVLCSGELTESMISDQIVQVVNGRHDLLKDADYSGPLTYQSMARLPAPYR--D 482
            ||.|:..||.:|:.:..|   :.:..||:..::....: |:|   .|..|.:||....|.:|  .
 Frog   425 SVSCVCTLLGTLEDISQG---KGLKEDQVQYLLRCIEE-LRD---GGESTRESMEINEADFRWQR 482

  Fly   483 AIVEFRQTVFE--------------TSSGSES-EGE-----PQHEQDAASNGSGDTEGPEDDDPS 527
            .::....|.:|              |.:|..: ||:     |:...|.....:.|.|..:..|..
 Frog   483 HVLSTEHTPWELGTEKSPDISISVTTDTGQTTLEGDLGQTTPEDNIDGKQLKNPDIEIVDQPDVV 547

  Fly   528 SSSDET--------SRVENRW----------------------------PYSHLEAPVMPIRTD- 555
            ..|..|        ..||:|.                            .|| :.|.....|:|
 Frog   548 QRSHVTVYPDITNFLSVESRTRSYGSRCSESNFSVDDQDLSRTEFDSCDQYS-IAAEKDSGRSDI 611

  Fly   556 ----SDN----------------------------------DRQHARDFARALRQDLVPKLLRLR 582
                |||                                  |:..||.|.::| .:::.:||.|:
 Frog   612 SDIGSDNCSLADEDQTPRDCPGHRSLRTAALSLNLLKVQEADQHSARFFVQSL-LNIIQRLLTLQ 675

  Fly   583 SCVELDEAMQEFAS-------AVCQENS--MNFSDFDYNLTAINADGIYLAIYSSLLLSLQLMRA 638
            ...|:|..:|.|||       |..|.:.  .|.|:..:. |.:||||:|...|.:|||:|:|:.:
 Frog   676 RIEEVDTTLQNFASTFYSSLQAGAQRSPGFENHSNIGFQ-TLLNADGLYTISYYALLLNLKLLNS 739

  Fly   639 GFYEQVAQGMSHKDILVPMSEQQFVTSVQNTGVLVYLSSPWLCELYQSVTVCNVL-EAMPRQQLE 702
            .:|.:       |..|..::.::|:..:|:||:.|: ...|:.|:|..|...|:| |:......|
 Frog   740 DYYRK-------KSALPCVTMKEFMKQLQSTGMFVF-PQAWVEEVYHQVLERNLLGESGYWSSPE 796

  Fly   703 GMGPRCA-LVDMLCDAGGLGATQMLSEWQRLQTANVKHK-EEEQLHDKRREAAKKLCRRLLTCCW 765
            |   .|. |:.||.:..|||.:.:  ..|.|.:|:.:.. ..|:..|....|.....|.:|..||
 Frog   797 G---HCVPLITMLLNIDGLGRSTI--GGQLLASASTQSTLPSERNLDPAVIAGVAFARYILIGCW 856

  Fly   766 DSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYAMCLDGLHSAATLSNSLNL 830
            .:::..||:.|......|:...:..|.  |..||.:..|....  ..|.||||..||.||.:|.:
 Frog   857 KNIIDTLSAPLTGRMAGSSKGLIFILG--TEGVKEQNLKERDS--ICMSLDGLRKAARLSCALGV 917

  Fly   831 QHLAGKILNLLASNVC----------------------------QTSGP----RISASQAMSMDV 863
            .......|..:|:..|                            :..|.    |:..:..:.||.
 Frog   918 AANCASALAQMAAASCVKEVKDEKENLKNSDAITQVKQKVEQKLEQMGKQGCYRLHPAHVLCMDS 982

  Fly   864 VLTGGLNLGSYSADCWPSIFAVCRHVSQLEHEIFSMQNPAISASPGSSRRDLETGEKLSNGNAQD 928
            :|..||.:||::.||||.:|.||.::..|||..|                        |:|.:|.
 Frog   983 ILKVGLEMGSHNQDCWPHVFRVCEYICTLEHTHF------------------------SDGMSQP 1023

  Fly   929 KLNLS---SIPIDDDETCVDVY---------SFLQAPMQSPNTNITSILK--VYSGTNETVLLSQ 979
            .|.::   .:|.|..|...|.:         |..::|:..| ..|..::|  ...||:   |:|.
 Frog  1024 SLTITQSQQLPSDCQEHATDCFQDYSSEQEGSLSKSPILQP-VPIQELIKEGAKGGTS---LMSG 1084

  Fly   980 SDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIWWPSKGWK 1044
            |:.:|.:|.||.:|:.||..||::|:|.:|..||..|.:||:.||:..........:..|.: .|
 Frog  1085 SNAAKAVCTLSTEADKLFEGAADQLNLMALNGFLYQLKKASQAQLFHLVTNTVHYSLAMPGE-VK 1148

  Fly  1045 KLDSLPMSLLLHRIGDVTLKVFRS-SRPLLHVLKVWAITGPHLMDAACHRDRMISKRAIEYIHDI 1108
            .......:|.|.|:|||.|::.|| ||||||::..|::..||.::||||::|.:|::|:.:||||
 Frog  1149 STQDRRSALHLFRLGDVMLRIIRSKSRPLLHIIHCWSLVAPHFVEAACHKERHVSQKAVSFIHDI 1213

  Fly  1109 ITALLVEQSELPYFHFNEALLKPFENLLSMD-TDVDVQDQIVACLYEVVEAHRTEIRSGWRPLFG 1172
            ||.:|....|.|:|:|||.|.:|||.::.:: .|.|||||::..:.|:||....:|:|||||||.
 Frog  1214 ITEVLSNWDEPPHFYFNETLFRPFERIMQLELCDEDVQDQVITSIGELVEMCSGQIQSGWRPLFS 1278

  Fly  1173 TLRNARSRMLNMSN--------------IIDIFRVFLDSDNTLVFANAGLDCILCLLSYLEISGG 1223
            :|........::..              :.|:|..||::.|..|||||..|.|:||:.:::   |
 Frog  1279 SLETVHCNKSDIKEYLVGNYTMGKRQAPVFDVFEAFLNTGNIQVFANAATDYIMCLMKFVK---G 1340

  Fly  1224 GNNNACSGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETLRFLERCSSILGFMHSMPKCPNFHST 1288
            .....|.......:|...|:            ||.....|.:|.|||.:|..::.||..|.|.|.
 Frog  1341 LGEVECKESGDCISGSVTSS------------TDLCLPALDYLRRCSQLLAKIYKMPVKPIFLSG 1393

  Fly  1289 YKIKGISYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHIDKDTIVKIDEMDKPSGVL 1353
            .:           ||               |..|.::     ||...|......:.|.|..:|::
 Frog  1394 RQ-----------AN---------------LHRRAQE-----RSESSDDGIEALLSEFDDDTGLI 1427

  Fly  1354 KVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASPGIDFGFYCINHLLVPMIQDWLRYIN 1418
            :||.:||:.||.|:..||..||.|.|..:|:|.:.:...||..|..|.:.|||:|::..||...:
 Frog  1428 EVWIILLEQLTASISNCPRQHQPPTLDLLFELLRGVAKVPGPGFAIYAVVHLLLPVMSVWLSRSH 1492

  Fly  1419 KTGSSWQLVEKNFKHCCCMTTDLVVEFIEKSVPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVT 1483
            .....|.....||||...:|.:||||.|:
 Frog  1493 GDHCYWDAASSNFKHAIGLTCELVVEHIQ------------------------------------ 1521

  Fly  1484 ERIEREQQQQQSPSVQDHGCGYTQQYDSSSSSASEEQQKNGGGVGGGGSNLIESPTKISGSATLA 1548
                                                             :||.|...........
 Frog  1522 -------------------------------------------------SLINSDIGYESMINTM 1537

  Fly  1549 LKQLLLVLIECAAQSQEAIARISVSCLKHVILSTGMLFNESQWMIACSAIHRACTVTIAPLRQLS 1613
            :|:|..:|:.|.|:..|.|:|:..||:::|:::.|.:|.|..|.:||.|:..|.:.|:.|::.|.
 Frog  1538 IKELFKLLVTCVAEPTETISRVGCSCIRYVLVTAGPVFTEEMWRLACCALQDAFSATLEPIKNLL 1602

  Fly  1614 FAFHEKSNSFYGDCANVKVAARRDSSLE-----ELARIYALAQQVFLSDNQREP--GQNQAPTPS 1671
            ..||..|.||.||...|||||   .||.     |..||.|:.||||:.|.|..|  ..|:.....
 Frog  1603 GYFHSGSESFSGDACEVKVAA---PSLSPNAEAEYWRIRAMTQQVFMLDAQCSPKTPNNKEGFEH 1664

  Fly  1672 ASQCKL-----SDDRSYSFLLYPLNNGFNSNLDNFVIRIPFKNLVVGLLANQMLLQLVAKLLLSR 1731
            |..|.|     .|:|.         ||....      .|||:.:||.||::|:|||.:..:||..
 Frog  1665 AQSCVLLIELPPDERP---------NGRTQK------SIPFRTIVVSLLSHQVLLQNLYDILLDE 1714

  Fly  1732 LKCVPQAVSTCIFDNYAASAASPSHDY--DLDFRSKEILLRCVKQYLMSALEFDSRPGLKFLMQK 1794
            .   .:.:|. |.|...:.....|..:  .:..::..::...:.....:|.|||:|||||.|:.|
 Frog  1715 F---VKGLSN-IEDKTISVTEGKSVGFLRYISMQNLAVIFDLLLDSYRTAREFDARPGLKCLLMK 1775

  Fly  1795 VSNIEYAANLYKQMTSSWMIYYIALV----------------------DSHLNDIVVYNLGPEDL 1837
            ||.|..:||||:|...|:.||:.:|:                      |.|..| .......||.
 Frog  1776 VSGIGGSANLYRQSAMSFKIYFHSLISALLTNQDTINAELVKKIIFEDDEHSTD-SSQQCSSEDE 1839

  Fly  1838 NFILESC--------------SRLNTTTVKKKEN-----FVR--YLFCLQDAWNLVCELYLSNSA 1881
            :...|:.              :|:.:.:|:...|     .||  |..|:.     :|..|:....
 Frog  1840 DIFEETAQVSPPRGKEKRQWRTRIPSQSVQPLSNADWAWLVRRLYKLCMD-----ICNNYIQMHL 1899

  Fly  1882 LHEIESGSGKLRQKP----PQLLHHPQTKPMCIS---------LNGNGDAEMTDT---GSGSGSG 1930
            ..|.:...| ::..|    |.:.....|...|:|         .|...|.::.:.   |.|||:|
 Frog  1900 DLENDDAPG-IKGDPFFILPSIQSETSTPSTCLSGRNTPSEDERNSIKDHQIENVLLKGFGSGAG 1963

  Fly  1931 -SSTSPSKCVQLQEEE--------------NVTMTTLISEFQP-KCRSNPFDTNRQAK-SSEAES 1978
             .|.:..|..|.:::|              :.|:..|::|::. |.:.||....:..| ..:.|:
 Frog  1964 PCSPNAEKRGQSKKKEWWESAGNKIYTIATDKTIAKLMTEYKKRKQQHNPTSFVKDTKVDKKGET 2028

  Fly  1979 ISP----EIEQQRASSILKDSNYKRAALAQLVVASMELLR 2014
            :||    .:..||..::: |....|.:.:    |..|:||
 Frog  2029 LSPRNQDSVMLQRPQNLV-DQTQMRHSFS----AGPEILR 2063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	74/346 (21%)
		DUF1981	1115..>1179	CDD:286414	28/64 (44%)
arfgef3	XP_031758024.1	DCB	5..167	CDD:406594	44/164 (27%)
		Sec7	570..785	CDD:412180	50/225 (22%)
		PLN03076	<982..1651	CDD:215560	240/831 (29%)
		DUF1981	1222..>1280	CDD:401312	27/57 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	312	1.000	Domainoid score	I1295
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1242
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27409at33208
OrthoFinder	1	1.000	-	-		FOG0007013
OrthoInspector	1	1.000	-	-		oto105160
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060