DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCTS1 and TMA64

DIOPT Version :9

Sequence 1:	NP_001245541.1	Gene:	MCTS1 / 31536	FlyBaseID:	FBgn0029833	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_010402.3	Gene:	TMA64 / 851695	SGDID:	S000002524	Length:	565	Species:	Saccharomyces cerevisiae

Alignment Length:	196	Identity:	46/196 - (23%)
Similarity:	85/196 - (43%)	Gaps:	40/196 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFKKFEEKDSISSIQQLKSSVQKGIRAKLLEAYPKLESHIDLILPKKDSYRIAKCHDHIELLLNG 65
            ||||   :..|.::..||:|.:|    |||:.:.|..::      ::.|:|.:...   :...||
Yeast     1 MFKK---EPHIKALSNLKNSERK----KLLQTFQKQTNN------EEYSFRTSTIK---QTNFNG 49

  Fly    66 A-----------GDQVFF--RHRDGPWMPTLRLLHKFPYFVTMQQVDKGAI-RFVLSGANVMCPG 116
            .           ...:.|  :|:: ...||:....::|..:.:.......| ..:.:|||:|..|
Yeast    50 QKSVGTVYTDENNTPILFKEKHKE-QLFPTVYSCWEYPALLPIVLTHGFVIEEHLFNGANLMISG 113

  Fly   117 LTSPGACMTPADK-DTVVAIMA-EGKEHALAVGLLTL---STQEILAKNKGIGIETYHFLNDGLW 176
            ...|   ..|..| .|:..|.: :..|..||:|::.|   |..:::.:. |:.::..|..||||.
Yeast   114 SIPP---FDPRCKIGTLCGIASKQAPETVLAIGIVELDLPSFDKVIGET-GVAVKIIHHFNDGLS 174

  Fly   177 K 177
            |
Yeast   175 K 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCTS1	NP_001245541.1	MCT1_N	4..81	CDD:211422	16/89 (18%)
		Tma20	18..177	CDD:224927	39/177 (22%)
		PUA	69..173	CDD:294405	24/111 (22%)
TMA64	NP_010402.3	Pre-PUA	2..86	CDD:407697	20/100 (20%)
		PUA_eIF2d-like	88..170	CDD:409298	19/85 (22%)
		eIF2D_C	474..556	CDD:211321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810