DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCTS1 and eIF2D

DIOPT Version :9

Sequence 1:	NP_001245541.1	Gene:	MCTS1 / 31536	FlyBaseID:	FBgn0029833	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_477481.1	Gene:	eIF2D / 64874	FlyBaseID:	FBgn0041588	Length:	563	Species:	Drosophila melanogaster

Alignment Length:	201	Identity:	52/201 - (25%)
Similarity:	84/201 - (41%)	Gaps:	40/201 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF-KKFEEKDSISSIQQLKSSVQKGIRAKLLEAYPKLESHIDLILPKKDSYRIAK---------- 54
            || |.:..|.|.:    ||.|..|..|.::..|:|.:.  :|.::|.|.:....|
  Fly     1 MFLKPYRPKSSAA----LKGSDSKKFRQRVEAAFPHVS--VDQLVPAKAAVTQVKILTHGGVQSM 59

  Fly    55 --CHDHIELLLNGAGDQVFFRHRDGPWMPTLRLL----HKFPYFVTMQQVDKGAIRFVLSGANVM 113
              |.|.:.|         ||....|..:|||..|    ...|||.|    .:|.:..:.:||::|
  Fly    60 VYCVDKLPL---------FFELDGGQLVPTLYTLWIVPDILPYFTT----HEGVLPKLTNGADLM 111

  Fly   114 CPGLTSPGACMT---PADKDTVVAIMAEGKEHALAVGLLTLSTQEI-LAKNKGIGIETYHFLNDG 174
            .||:...|..::   ...|..::|:.....:.|:.||.|..|:.|: :....|:.|:..|...|.
  Fly   112 LPGVVPLGVGLSMYGHFKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDK 176

  Fly   175 LWKSKP 180
            ||..:|
  Fly   177 LWSHEP 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCTS1	NP_001245541.1	MCT1_N	4..81	CDD:211422	19/88 (22%)
		Tma20	18..177	CDD:224927	44/178 (25%)
		PUA	69..173	CDD:294405	29/111 (26%)
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	19/87 (22%)
		Tma20	9..178	CDD:224927	46/187 (25%)
		PUA	61..175	CDD:294405	32/126 (25%)
		eIF2D_C	469..551	CDD:211321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2016
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810