DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCTS1 and Eif2d

DIOPT Version :9

Sequence 1:	NP_001245541.1	Gene:	MCTS1 / 31536	FlyBaseID:	FBgn0029833	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_001017489.1	Gene:	Eif2d / 498225	RGDID:	1561765	Length:	570	Species:	Rattus norvegicus

Alignment Length:	189	Identity:	51/189 - (26%)
Similarity:	88/189 - (46%)	Gaps:	21/189 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF-KKFEEKDSISSIQQLKSSVQKGIRAKLLEAYPKL-ESHIDLILPKKDSYRIAKCHDH----I 59
            || |.|..|.:.:    :|.|.::.:||.:..|:|.| ...:..::|.|:...:.|.:.|    :
  Rat     1 MFAKAFRVKSNTA----IKGSDRRKLRADVTVAFPTLGTDQVSELIPGKEELNVVKLYAHKGDAV 61

  Fly    60 ELLLNGAGDQVFFRHRDGPWMPTLRLLHK----FPYFVTMQQVDKGAIRFVLSGANVMCPGLTSP 120
            .:..:| |:.:.|......: ||:..|..    .|.|:|...|    :..::.||::|.||:..|
  Rat    62 TVYTSG-GNPILFELEKNLY-PTVYTLWSHPDLLPAFITWPLV----LEKLVGGADLMLPGVVVP 120

  Fly   121 GACMTPADKDTVVAIMAEGKEHALAVGLLTLSTQEILAKN-KGIGIETYHFLNDGLWKS 178
            ...:....:..:.||...|....:|||:..:||.::||.. ||.||...|...|.||:|
  Rat   121 PTGLPQVQQGDLCAIALVGNRAPVAVGVAAMSTAQMLASGLKGKGISVLHTYQDHLWRS 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCTS1	NP_001245541.1	MCT1_N	4..81	CDD:211422	16/81 (20%)
		Tma20	18..177	CDD:224927	44/168 (26%)
		PUA	69..173	CDD:294405	29/108 (27%)
Eif2d	NP_001017489.1	eIF2D_N	6..81	CDD:211423	16/80 (20%)
		Tma20	7..178	CDD:224927	45/180 (25%)
		PUA	68..174	CDD:294405	30/110 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..200		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..243
		eIF2D_C	477..561	CDD:211321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810