DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCTS1 and eif2d

DIOPT Version :9

Sequence 1:	NP_001245541.1	Gene:	MCTS1 / 31536	FlyBaseID:	FBgn0029833	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	NP_989398.1	Gene:	eif2d / 395035	XenbaseID:	XB-GENE-947279	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	192	Identity:	55/192 - (28%)
Similarity:	87/192 - (45%)	Gaps:	31/192 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF-KKFEEKDSISSIQQLKSSVQKGIRAKLLEAYPKLES-HIDLILPKKDSYRIAKCHDHIELLL 63
            || |.|..|.:.:    :|.|.::.:||.:..|:|.|.: ::..::|.|:...|.|...|
Frog     1 MFAKNFRVKSNTA----IKGSDRRKLRADISSAFPFLTTENLSELMPSKEELSIVKVFAH----- 56

  Fly    64 NGAGDQV-FFRHRDGPWM--------PTLRLLHKF----PYFVTMQQVDKGAIRFVLSGANVMCP 115
              .||.| .:.|...|.|        ||:..|.|:    |.|.|...|    :..:..||::|.|
Frog    57 --KGDAVTLYVHNRNPVMFELEKNLYPTVYALWKYPDLLPAFTTWPPV----LEKMAGGADLMLP 115

  Fly   116 GLTSPGACMTPADKDTVVAIMAEGKEHALAVGLLTLSTQEILAKN-KGIGIETYHFLNDGLW 176
            |:..|...:....:.::.||...|....:|||:.|:|::|:||.. ||.|....|...|.||
Frog   116 GVVVPSFGLPEIQQGSLCAITLVGNRAPVAVGVATMSSKEMLASGMKGKGFNILHTFGDQLW 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCTS1	NP_001245541.1	MCT1_N	4..81	CDD:211422	20/86 (23%)
		Tma20	18..177	CDD:224927	50/174 (29%)
		PUA	69..173	CDD:294405	33/117 (28%)
eif2d	NP_989398.1	Pre-PUA	2..90	CDD:375366	26/98 (27%)
		Tma20	7..177	CDD:224927	49/184 (27%)
		eIF2D_C	495..579	CDD:211321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000