DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4766 and TMEM102

DIOPT Version :9

Sequence 1:	NP_572287.1	Gene:	CG4766 / 31533	FlyBaseID:	FBgn0027546	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_001307373.1	Gene:	TMEM102 / 284114	HGNCID:	26722	Length:	508	Species:	Homo sapiens

Alignment Length:	191	Identity:	44/191 - (23%)
Similarity:	63/191 - (32%)	Gaps:	47/191 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 RERFVVQITPAFKCSGIWPRSA-AHWPVPHLPWPHPNIVAEVKTEGFDLLSKESVIMQNKNNNAA 232
            |...:..:.|....:| ||..| :|      .|..|            |.|:.:...........
Human   311 RRLLLFDLIPVVSVAG-WPEGARSH------SWAGP------------LASESASFYLVPGGGTE 356

  Fly   233 SMEGDAWVLSFFEAE--------NRLLQGGCRRRCLSMLKTLRDRHLDLPGNPISA-YHLKNLLL 288
            .....||.|.|...|        ..|||.....:.|  |:.|      :.|...:| |.|:.||.
Human   357 RPCASAWQLCFARQELALKARIPAPLLQAHAAAQAL--LRPL------VAGTRAAAPYLLRTLLY 413

  Fly   289 YECEKHP-----RDFEWDEGCIADRINGIFLQLISCLQYRRCPHYFLPALDMFKGKSPSAL 344
            :.||:.|     |.......|:     |:..:|...|:....|||||....:..|...:||
Human   414 WACERLPALYLARPENAGACCL-----GLLDELGRVLEAGTLPHYFLNGRQLRTGDDSAAL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4766	NP_572287.1	Mab-21	68..353	CDD:281298	44/191 (23%)
TMEM102	NP_001307373.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..231
TMEM102	NP_001307373.1	Mab-21	<317..455	CDD:308741	38/169 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10656
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910