DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4766 and Cgas

DIOPT Version :9

Sequence 1:	NP_572287.1	Gene:	CG4766 / 31533	FlyBaseID:	FBgn0027546	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_775562.2	Gene:	Cgas / 214763	MGIID:	2442261	Length:	507	Species:	Mus musculus

Alignment Length:	398	Identity:	89/398 - (22%)
Similarity:	168/398 - (42%)	Gaps:	98/398 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ERVQARMYKTATAIREICKIVQDILKEVELQEPRF--ISSLVECNGRFEGVEVISPNEFEIVLYL 86
            ::::.:....:.|...:.|:|:.:|:.::.:|..|  :..| .....:|.|::.:||||:::..|
Mouse   155 DKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL-NTGSYYEHVKISAPNEFDVMFKL 218

  Fly    87 N----------QMGVFNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSSRKIRARFQTL 141
            .          :.|.|..|....:|          |...:|.::|    ...||:.|:.::|:.:
Mouse   219 EVPRIELQEYYETGAFYLVKFKRIP----------RGNPLSHFLE----GEVLSATKMLSKFRKI 269

  Fly   142 VAQACDKSVYRDMVKMVGD-----------TSEVKLRIR--ERFVVQITPAFKCSGIWPRSAAHW 193
            :         ::.||.:.|           :..|.|.||  |...|.|..|.:..|.||.|...
Mouse   270 I---------KEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKE- 324

  Fly   194 PVPHLPWPHPNIVAEVKTEGFDLLSKESVIMQNKNNNAASMEGDAWVLSFFEAENRLLQGG---- 254
            .:|...|....:...::.|.|.|:.|.:     |:.|  |.:|:.|.|||...|..:|...
Mouse   325 GLPIQGWLGTKVRTNLRREPFYLVPKNA-----KDGN--SFQGETWRLSFSHTEKYILNNHGIEK 382

  Fly   255 ----------CRRRCLSMLKTLRD------RHLDLPGNPISAYHLKNLLLYECEKHPRDFEWD-- 301
                      ||:.||.::|.|.:      :.||    ...:||:|..:.:...:.|:|.:||
Mouse   383 TCCESSGAKCCRKECLKLMKYLLEQLKKEFQELD----AFCSYHVKTAIFHMWTQDPQDSQWDPR 443

  Fly   302 --EGCIADRINGIFLQLISCLQYRRCPHYFLPALDMFKGKSPSALEQAAKQVWRLTRELLTNAN- 363
              ..|. |::...||:   ||:..:..|||:|..::|   |...:::.:|:.  |::::....|
Mouse   444 NLSSCF-DKLLAFFLE---CLRTEKLDHYFIPKFNLF---SQELIDRKSKEF--LSKKIEYERNN 499

  Fly   364 ---AFEKL 368
               .|:||
Mouse   500 GFPIFDKL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4766	NP_572287.1	Mab-21	68..353	CDD:281298	77/331 (23%)
Cgas	NP_775562.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151
		DNA-binding. /evidence=ECO:0000269\|PubMed:28363908	1..146
		PHA03247	<3..142	CDD:223021
		Required for association with the cell membrane. /evidence=ECO:0000250\|UniProtKB:Q8N884	48..59
		Required for activation upon DNA viral infection. /evidence=ECO:0000269\|PubMed:28314590	119..132
		DNA-binding. /evidence=ECO:0000269\|PubMed:23647843, ECO:0000269\|PubMed:28902841, ECO:0000269\|PubMed:28963528, ECO:0007744\|PDB:5N6I	158..201		7/43 (16%)
		Mab-21	200..495	CDD:397398	78/338 (23%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8N884	281..291		0/9 (0%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:23647843, ECO:0000269\|PubMed:28902841, ECO:0000269\|PubMed:28963528, ECO:0007744\|PDB:5N6I	372..395		2/22 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810