DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4766 and mab-21

DIOPT Version :9

Sequence 1:	NP_572287.1	Gene:	CG4766 / 31533	FlyBaseID:	FBgn0027546	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_497940.2	Gene:	mab-21 / 175607	WormBaseID:	WBGene00003112	Length:	364	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	203/365 - (55%)
Similarity:	267/365 - (73%)	Gaps:	4/365 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MMAAQTRMVYQMNRFCTERVQARMYKTATAIREICKIVQDILKEVELQEPRFISSLVE-CNGRFE 70
            |:.....:|||:|.:..|:||.|..:....::.|.|:||:||||||.||||||::|.| ..|||:
Worm     1 MLGHNQNVVYQVNNYFNEKVQHRKVRVTKTVQRIAKVVQEILKEVEAQEPRFINTLSETTTGRFD 65

  Fly    71 GVEVISPNEFEIVLYLNQMGVFNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSSRKIR 135
            |:.|.||:|:|.|||||||||||||||||:.|||||||||||||||||||||||||||||:||||
Worm    66 GIVVHSPSEYEAVLYLNQMGVFNFVDDGTIQGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIR 130

  Fly   136 ARFQTLVAQACDKSVYRDMVKMVGDTSEVKLRIRERFVVQITPAFKCSGIWPRSAAHWPVPHLPW 200
            .|||.:|||......:.|..|::.|.::|::|:.:::.||||.||:|:|||||||:|||:..|||
Worm   131 HRFQNIVAQVLQTPQFSDYCKLLQDNTDVRVRVDDKYTVQITCAFRCNGIWPRSASHWPIAGLPW 195

  Fly   201 PHPNIVAEVKTEGFDLLSKESVIMQ--NKNNNAASMEGDAWVLSFFEAENRLLQGGCRRRCLSML 263
            |:..:..:.|.|||||.|:|:.|.|  |.|..|:|||.|||.:....|||.||.|| ||:.||:|
Worm   196 PNAALANQTKAEGFDLTSRETAITQQNNPNKQASSMEADAWAMKMHGAENMLLTGG-RRKTLSIL 259

  Fly   264 KTLRDRHLDLPGNPISAYHLKNLLLYECEKHPRDFEWDEGCIADRINGIFLQLISCLQYRRCPHY 328
            |.|||.|:|.||.|::.|.||.|:|||||||..::||::..|.||:.||.|||:||||.|||.||
Worm   260 KCLRDAHMDFPGTPVTNYILKTLVLYECEKHCSEYEWEDPNIGDRLVGILLQLVSCLQCRRCAHY 324

  Fly   329 FLPALDMFKGKSPSALEQAAKQVWRLTRELLTNANAFEKL 368
            |||:||:.:.|...::|.:|:..|.|.|:|:.:.||.:.|
Worm   325 FLPSLDLLRSKPVHSIEHSAQLAWHLVRKLMIDPNALQSL 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4766	NP_572287.1	Mab-21	68..353	CDD:281298	168/286 (59%)
mab-21	NP_497940.2	Mab-21	63..349	CDD:281298	168/286 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165397
Domainoid	1	1.000	356	1.000	Domainoid score	I510
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	422	1.000	Inparanoid score	I998
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48626
OrthoDB	1	1.010	-	-		D336176at33208
OrthoFinder	1	1.000	-	-		FOG0002743
OrthoInspector	1	1.000	-	-		otm14714
orthoMCL	1	0.900	-	-		OOG6_105865
Panther	1	1.100	-	-	LDO	PTHR10656
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2624
SonicParanoid	1	1.000	-	-		X1828
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800