DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4766 and MAB21L3

DIOPT Version :9

Sequence 1:	NP_572287.1	Gene:	CG4766 / 31533	FlyBaseID:	FBgn0027546	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_689580.2	Gene:	MAB21L3 / 126868	HGNCID:	26787	Length:	362	Species:	Homo sapiens

Alignment Length:	363	Identity:	85/363 - (23%)
Similarity:	163/363 - (44%)	Gaps:	64/363 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RVQARMYKTATAIREICKIVQDILKEVELQEPRFISSLVECNGRF-EGVEVISPNEFEIVLYLNQ 88
            :|..|..:.:.|:.|:.|:|..:...:..|:.||  ..|..:..: |.::|::|::|.:.:.:..
Human    16 KVDLRRQQISQAVEEVQKVVHHLTTNISNQDIRF--QAVPYSDTYNENIKVLAPSQFLVTVPIKG 78

  Fly    89 MGVFN---------FVDDGTLPGCAVLKLSDGRK---------RSMSLWVEF-ITASGYLSSRKI 134
            :..:.         :...||...|. |:..:|.:         :|:..|.|. :...|.:...|:
Human    79 LAGYREAREQHWRYYTLQGTRLPCP-LRDPEGLQQWLEVEQFMKSLWQWHETDVNIDGDIVPAKV 142

  Fly   135 RARFQTLVAQACDKSVYRDMVKMVGDTSEVKLRIRE---RFVVQITPAFKCSGIWPRSAAHWPVP 196
            ...|:.||..|.........|.::|:.|.|.:.:..   :..:::.||.:....|.:. |.||..
Human   143 LLVFRKLVENAVRTCHLSGKVSLLGNRSAVWVAVETSAYQVELELVPAVEIPTTWSKK-ARWPRC 206

  Fly   197 HLPWPHPNIVAEVKTEGFDLLSKESVIMQNKNNNAASMEGDAWVLSFFEAENRLLQ-----GGCR 256
            ...||....|..:|:.||:||:..:.               .|.|||..||..||:     ||||
Human   207 LQRWPSQERVECIKSFGFNLLACSNY---------------HWQLSFLRAEQVLLEQLDEDGGCR 256

  Fly   257 RRCLSMLKTLRDRHLDL--PGN--PISAYHLKNLLLYECEKHPRDFEWDEGCIADRINGIFLQLI 317
            |:|..:::.|::   |:  |||  .|:::||:.:|.:.|||:|...:|..      .:..||:|:
Human   257 RKCFQVMRHLKE---DIWCPGNRPVITSHHLQTVLFWTCEKYPHFKDWQV------FSKAFLRLV 312

  Fly   318 ----SCLQYRRCPHYFLPALDMFKGKSPSALEQAAKQV 351
                .|:......|||:...::|:..:|:.|:..|:::
Human   313 RKLHKCVSQHFLKHYFVRNSNLFQCTNPTELDTVAQKL 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4766	NP_572287.1	Mab-21	68..353	CDD:281298	75/320 (23%)
MAB21L3	NP_689580.2	Mab-21	58..351	CDD:308741	75/319 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10656
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910