DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4766 and MAB21L2

DIOPT Version :9

Sequence 1:	NP_572287.1	Gene:	CG4766 / 31533	FlyBaseID:	FBgn0027546	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_006430.1	Gene:	MAB21L2 / 10586	HGNCID:	6758	Length:	359	Species:	Homo sapiens

Alignment Length:	362	Identity:	267/362 - (73%)
Similarity:	309/362 - (85%)	Gaps:	3/362 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MMAAQTRMVYQMNRFCTERVQARMYKTATAIREICKIVQDILKEVELQEPRFISSLVECNGRFEG 71
            |:|||.::|||:|::.|||.|||....|..|||:||:|.|:|||||:|||||||||.|.:.|:||
Human     1 MIAAQAKLVYQLNKYYTERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIDARYEG 65

  Fly    72 VEVISPNEFEIVLYLNQMGVFNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSSRKIRA 136
            :|||||.|||:||||||||||||||||:|||||||||||||||||||||||||||||||:||||:
Human    66 LEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRS 130

  Fly   137 RFQTLVAQACDKSVYRDMVKMVGDTSEVKLRIRERFVVQITPAFKCSGIWPRSAAHWPVPHLPWP 201
            |||||||||.||..|||:|||:.||||||||||||:||||||||||:||||||||.||:||:|||
Human   131 RFQTLVAQAVDKCSYRDVVKMIADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWP 195

  Fly   202 HPNIVAEVKTEGFDLLSKESVIMQNKNNNAASMEGDAWVLSFFEAENRLLQGGCRRRCLSMLKTL 266
            .||.|||||.|||:|||||...:..|.::|   |.|||||.|.|||||||.||||.:|||:||||
Human   196 GPNRVAEVKAEGFNLLSKECYSLTGKQSSA---ESDAWVLQFGEAENRLLMGGCRNKCLSVLKTL 257

  Fly   267 RDRHLDLPGNPISAYHLKNLLLYECEKHPRDFEWDEGCIADRINGIFLQLISCLQYRRCPHYFLP 331
            |||||:|||.|::.||:|.|||||||||||:.:|||.|:.||:|||.||||||||.|||||||||
Human   258 RDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDESCLGDRLNGILLQLISCLQCRRCPHYFLP 322

  Fly   332 ALDMFKGKSPSALEQAAKQVWRLTRELLTNANAFEKL 368
            .||:|:||..||||.||||.|||.||:|||..:.:||
Human   323 NLDLFQGKPHSALESAAKQTWRLAREILTNPKSLDKL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4766	NP_572287.1	Mab-21	68..353	CDD:281298	220/284 (77%)
MAB21L2	NP_006430.1	Mab-21	62..344	CDD:397398	220/284 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157240
Domainoid	1	1.000	483	1.000	Domainoid score	I404
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7824
Inparanoid	1	1.050	580	1.000	Inparanoid score	I1025
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48626
OrthoDB	1	1.010	-	-		D336176at33208
OrthoFinder	1	1.000	-	-		FOG0002743
OrthoInspector	1	1.000	-	-		mtm8572
orthoMCL	1	0.900	-	-		OOG6_105865
Panther	1	1.100	-	-	O	PTHR10656
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2624
SonicParanoid	1	1.000	-	-		X1828
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800