DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5966 and Pnlip

DIOPT Version :9

Sequence 1:	NP_572286.1	Gene:	CG5966 / 31532	FlyBaseID:	FBgn0029831	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_081201.2	Gene:	Pnlip / 69060	MGIID:	97722	Length:	465	Species:	Mus musculus

Alignment Length:	497	Identity:	165/497 - (33%)
Similarity:	249/497 - (50%)	Gaps:	70/497 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CFGVYGCFPINGPWN-TVTRSINVHPQKPSEIEPHFTLHTRRALDQPKYLDLNDPESVQGMGMNP 109
            ||...|||..:.||: |:.|.:...|..|::|...|.|:|....|..: |..:|..:::......
Mouse    20 CFDKLGCFSDDAPWSGTLDRPLKALPWSPAQINTRFLLYTNENPDNYQ-LITSDASNIRNSNFRT 83

  Fly   110 KGKIFLLVHGYLESGEIPWMWDMAKALLAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGAIT 174
            ..|..:::||:::.||..|:.||.|.:...|   ..:.:.:||.||:...|.||..|:|:|||..
Mouse    84 NRKTRIIIHGFIDKGEENWLSDMCKNMFRVE---SVNCICVDWKGGSRTTYTQATQNVRVVGAEV 145

  Fly   175 AHVVHMLYEELRLPNLDNVHIIGHSLGAHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTDPI 239
            |.:|::|..:|.. :|:|||:||||||:|::|.||   :..|| ...||||||||.|.|..|...
Mouse   146 ALLVNVLQSDLGY-SLNNVHLIGHSLGSHIAGEAG---KRTFG-AIGRITGLDPAEPYFQGTPEE 205

  Fly   240 VRLDKTDAHFVDIVHTDANPLMKG-GLGINMRLGHVDFFPNGGFDNPGCNKK-FQDVVKKKTLFL 302
            ||||.|||.|||.:||||.|::.. |.|::..:||:|||||||.:.|||.|. ...:|....::.
Mouse   206 VRLDPTDAQFVDAIHTDAGPIIPNLGFGMSQTVGHLDFFPNGGIEMPGCQKNILSQIVDIDGIWE 270

  Fly   303 TMQEFLGCNHIRSQQYFTESIGSQCPFLGITCDSFESFKDTKCTSCEEPGHTCLRMGYHSQEDYQ 367
            ..:.|..|||:||.:::|:||.:...|.|.:|.|:..|...||..|...|  |.:|| |..:.|.
Mouse   271 GTRNFAACNHLRSYKFYTDSIVNPTGFAGFSCSSYSLFTANKCFPCGSGG--CPQMG-HYADRYP 332

  Fly   368 EQVDLGQLQQGDSPGVFYLWTGDSKPFCRLHYRITV-----RVSGHDESTLHGGEVGILSIQLHD 427
            .:.  .:|.|     .|||.|||...|.|..|::||     :|:||...:|.|.
Mouse   333 GKT--SRLYQ-----TFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGN----------- 379

  Fly   428 ALVKKAGKNERAATEMMKFSQKAMYFEPG----YEYKALVAGRNLREPEYATVNWEYPTNILNPL 488
                  |.|.: ..|:.|.|     .:||    .|:.:.|...:|::.::...|     |::||
Mouse   380 ------GGNSK-QYEVFKGS-----LQPGTSHVNEFDSDVDVGDLQKVKFIWYN-----NVINP- 426

  Fly   489 TWRILSAPRIYLEYILIEAMESSDLYLKLCPQ---HEGAILT 527
                 :.|::....|.:|  .:.......|.|   .|..:||
Mouse   427 -----TLPKVGASRITVE--RNDGRVFNFCSQETVREDVLLT 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5966	NP_572286.1	Lipase	46..394	CDD:278576	133/350 (38%)
CG5966	NP_572286.1	Pancreat_lipase_like	76..390	CDD:238363	120/315 (38%)
Pnlip	NP_081201.2	Lipase	18..352	CDD:278576	133/350 (38%)
		Pancreat_lipase_like	51..348	CDD:238363	120/315 (38%)
		PLAT_PL	355..465	CDD:238857	30/143 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2419
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30999
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3275
Isobase	1	0.950	-	0	Normalized mean entropy	S7341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	1	1.000	-	-		FOG0001245
OrthoInspector	1	1.000	-	-		otm43283
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5841
SonicParanoid	1	1.000	-	-		X699
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.910