DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5966 and PNLIPRP2

DIOPT Version :9

Sequence 1:	NP_572286.1	Gene:	CG5966 / 31532	FlyBaseID:	FBgn0029831	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_005387.3	Gene:	PNLIPRP2 / 5408	HGNCID:	9157	Length:	469	Species:	Homo sapiens

Alignment Length:	509	Identity:	163/509 - (32%)
Similarity:	255/509 - (50%)	Gaps:	79/509 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CFGVYGCFPINGPW-NTVTRSINVHPQKPSEIEPHFTLHTRRALDQPKYLDLNDPESVQGMGMNP 109
            |:|..|||....|| .|:.|.:.:.|..|.:|:..|.|:|....:..:.:...:|::::......
Human    21 CYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNFQLITGTEPDTIEASNFQL 85

  Fly   110 KGKIFLLVHGYLESGEIPWMWDMAKALLAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGAIT 174
            ..|...::||:|:..|..|..||.|.:...|   :.:.:.:||..|:...|.|||.|||:|||.|
Human    86 DRKTRFIIHGFLDKAEDSWPSDMCKKMFEVE---KVNCICVDWRHGSRAMYTQAVQNIRVVGAET 147

  Fly   175 AHVVHMLYEELRLPNLDNVHIIGHSLGAHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTDPI 239
            |.::..|..:|.. :|::||:||||||||.:..||..|    |.:..||||||||.|.|.|....
Human   148 AFLIQALSTQLGY-SLEDVHVIGHSLGAHTAAEAGRRL----GGRVGRITGLDPAGPCFQDEPEE 207

  Fly   240 VRLDKTDAHFVDIVHTDANPLMKG-GLGINMRLGHVDFFPNGGFDNPGCNKKFQDVVKKKTLFLT 303
            ||||.:||.|||::|||::|::.. |.|::.::||:|||||||.:.|||         ||.:..|
Human   208 VRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGC---------KKNVLST 263

  Fly   304 MQE----------FLGCNHIRSQQYFTESIGSQCPFLGITCDSFESFKDTKCTSCEEPGHTCLRM 358
            :.:          |:.|||:||.:|::.|:.:...|||..|.|::.|:::||..|  |...|.:|
Human   264 ITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPC--PAEGCPKM 326

  Fly   359 GYHSQEDYQEQVDLGQLQQGDSPGV---FYLWTGDSKPFCRLHYRITVRVSGHDESTLHGGEVGI 420
            |:     |.:|.      :|.:..|   |:|.||:|..|....|:::|.:||.::..      |.
Human   327 GH-----YADQF------KGKTSAVEQTFFLNTGESGNFTSWRYKVSVTLSGKEKVN------GY 374

  Fly   421 LSIQLHDALVKKAGKNERAAT-EMMKFSQKAMYFEPGYEYK-ALVAGRNLREPEYATVNWEYPTN 483
            :.|.|:       |.||.:.. |:.|.|.|     |...:. |:....|:.:.:.....|.  ..
Human   375 IRIALY-------GSNENSKQYEIFKGSLK-----PDASHTCAIDVDFNVGKIQKVKFLWN--KR 425

  Fly   484 ILNPLTWRILSAPRIYLEYILIEAMESSDLYLKLCPQHEGAILTGAENVLRSSY 537
            .:|      ||.|::....|.:::.|....| ..|...     |..||||:|.|
Human   426 GIN------LSEPKLGASQITVQSGEDGTEY-NFCSSD-----TVEENVLQSLY 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5966	NP_572286.1	Lipase	46..394	CDD:278576	129/362 (36%)
CG5966	NP_572286.1	Pancreat_lipase_like	76..390	CDD:238363	116/327 (35%)
PNLIPRP2	NP_005387.3	Lipase	18..354	CDD:395099	129/362 (36%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	93..105		4/11 (36%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	257..279		4/21 (19%)
		PLAT_PL	357..469	CDD:238857	33/143 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2491
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3369
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	1	1.000	-	-		FOG0001245
OrthoInspector	1	1.000	-	-		otm41219
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5841
SonicParanoid	1	1.000	-	-		X699
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.100