DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5966 and PNLIP

DIOPT Version :9

Sequence 1:	NP_572286.1	Gene:	CG5966 / 31532	FlyBaseID:	FBgn0029831	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	471	Identity:	149/471 - (31%)
Similarity:	230/471 - (48%)	Gaps:	61/471 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CFGVYGCFPINGPWNTVT-RSINVHPQKPSEIEPHFTLHTRRALDQPKYLD--LNDPESVQGMGM 107
            |:...|||..:.||:.:| |.:::.|..|.::...|.|:|.   :.|....  ..|..|:.|...
Human    20 CYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTN---ENPNNFQEVAADSSSISGSNF 81

  Fly   108 NPKGKIFLLVHGYLESGEIPWMWDMAKALLAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGA 172
            ....|...::||:::.||..|:.::.|.|...|   ..:.:.:||.||:...|.||..|||:|||
Human    82 KTNRKTRFIIHGFIDKGEENWLANVCKNLFKVE---SVNCICVDWKGGSRTGYTQASQNIRIVGA 143

  Fly   173 ITAHVVHMLYEELRLPNLDNVHIIGHSLGAHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTD 237
            ..|:.|..|...... :..|||:||||||||.:|.||.......|    ||||||||.|.|..|.
Human   144 EVAYFVEFLQSAFGY-SPSNVHVIGHSLGAHAAGEAGRRTNGTIG----RITGLDPAEPCFQGTP 203

  Fly   238 PIVRLDKTDAHFVDIVHTDANPLMKG-GLGINMRLGHVDFFPNGGFDNPGCNKK-FQDVVKKKTL 300
            .:||||.:||.|||::|||..|::.. |.|::..:||:|||||||.:.|||.|. ...:|....:
Human   204 ELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGI 268

  Fly   301 FLTMQEFLGCNHIRSQQYFTESIGSQCPFLGITCDSFESFKDTKCTSCEEPGHTCLRMGYHSQED 365
            :...::|..|||:||.:|:|:||.:...|.|..|.|:..|...||..|  |...|.:||:::...
Human   269 WEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPC--PSGGCPQMGHYADRY 331

  Fly   366 YQEQVDLGQLQQGDSPGVFYLWTGDSKPFCRLHYRITV-----RVSGHDESTLHGGEVGILSIQL 425
            ..:..|:||        .|||.|||:..|.|..|:::|     :|:||...:|.|.:......::
Human   332 PGKTNDVGQ--------KFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEI 388

  Fly   426 HDALVKKAGKNERAATEMMKFSQKAMYFEPGYEYKALVAGRNLREPEYATVNWEYPTNILNPLTW 490
            ....:|....:..                   |:.:.|...:|:..::...|     |::||
Human   389 FKGTLKPDSTHSN-------------------EFDSDVDVGDLQMVKFIWYN-----NVINP--- 426

  Fly   491 RILSAPRIYLEYILIE 506
               :.||:....|::|
Human   427 ---TLPRVGASKIIVE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5966	NP_572286.1	Lipase	46..394	CDD:278576	128/352 (36%)
CG5966	NP_572286.1	Pancreat_lipase_like	76..390	CDD:238363	116/317 (37%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	128/352 (36%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857	19/115 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2491
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30999
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3369
Isobase	1	0.950	-	0	Normalized mean entropy	S7341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	1	1.000	-	-		FOG0001245
OrthoInspector	1	1.000	-	-		otm41219
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5841
SonicParanoid	1	1.000	-	-		X699
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.910