DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5966 and Lpl

DIOPT Version :9

Sequence 1:NP_572286.1 Gene:CG5966 / 31532 FlyBaseID:FBgn0029831 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_036730.1 Gene:Lpl / 24539 RGDID:3017 Length:474 Species:Rattus norvegicus


Alignment Length:355 Identity:113/355 - (31%)
Similarity:172/355 - (48%) Gaps:34/355 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 SEIEPHFTLHT-RRALDQPKYLDLNDPESVQGMGMNPKGKIFLLVHGYLESGEI-PWMWDMAKAL 136
            |:||..|.|.| ....:...:|.....:||.....|...|.|:::||:..:|.. .|:..:..||
  Rat    35 SDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAAL 99

  Fly   137 LAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGAITAHVVHMLYEELRLPNLDNVHIIGHSLG 201
            ...||:  ::|:::||...|...|..:....:|||...|..::.|.||...| |||||::|:|||
  Rat   100 YKREPD--SNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYP-LDNVHLLGYSLG 161

  Fly   202 AHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTDPIVRLDKTDAHFVDIVHTDANPLMKGGLG 266
            ||.:|.||.....    |..||||||||.|.|...:...||...||.|||::||.........:|
  Rat   162 AHAAGVAGSLTNK----KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIG 222

  Fly   267 INMRLGHVDFFPNGGFDNPGCN-KKFQDVVKKKTLFLTMQEFLGCNHIRSQQYFTES-IGSQCPF 329
            |...:||||.:||||...|||| .:...|:.:|.|. .:.:.:.|:|.||...|.:| :..:.|.
  Rat   223 IQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLG-DVDQLVKCSHERSIHLFIDSLLNEENPS 286

  Fly   330 LGITCDSFESFKDTKCTSCEEPGHTCLRMGYHSQEDYQEQVDLGQLQQGDSPGVFYLWTGDSKPF 394
            ....|:|.|:|:...|.||.:  :.|..:||          ::.:::...| ...||.|....|:
  Rat   287 KAYRCNSKEAFEKGLCLSCRK--NRCNNVGY----------EINKVRAKRS-SKMYLKTRSQMPY 338

  Fly   395 CRLHYRITVRVSGHD---------ESTLHG 415
            ...||::.:..||.:         |.:|:|
  Rat   339 KVFHYQVKIHFSGTENDKQNNQAFEISLYG 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5966NP_572286.1 Lipase 46..394 CDD:278576 105/323 (33%)
Pancreat_lipase_like 76..390 CDD:238363 104/317 (33%)
LplNP_036730.1 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 6/17 (35%)
lipo_lipase 33..472 CDD:132274 113/355 (32%)
Pancreat_lipase_like 37..334 CDD:238363 104/317 (33%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 5/23 (22%)
PLAT_LPL 341..465 CDD:238856 7/28 (25%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D247005at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.020

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