DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5966 and Pnliprp2

DIOPT Version :9

Sequence 1:	NP_572286.1	Gene:	CG5966 / 31532	FlyBaseID:	FBgn0029831	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_035258.2	Gene:	Pnliprp2 / 18947	MGIID:	1336202	Length:	482	Species:	Mus musculus

Alignment Length:	365	Identity:	131/365 - (35%)
Similarity:	200/365 - (54%)	Gaps:	21/365 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CFGVYGCFPINGPW-NTVTRSINVHPQKPSEIEPHFTLHTRRALDQPKYLDLNDPESVQGMGMNP 109
            |:|..|||..:.|| ..:.|...:.|..|.:|:..|.|:|....:..:.:...||.::.......
Mouse    34 CYGHLGCFSNDKPWAGMIQRPSKIFPWSPEDIDTRFLLYTNENPNNYQIISATDPATINASNFQL 98

  Fly   110 KGKIFLLVHGYLESGEIPWMWDMAKALLAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGAIT 174
            ..|...::||:::.||..|:.||.|.:...|   :.:.:.:||..|:...|.||..|.|:|||..
Mouse    99 DRKTRFIIHGFIDKGEEGWLLDMCKKMFQVE---KVNCICVDWKRGSRTEYTQASYNTRVVGAEI 160

  Fly   175 AHVVHMLYEELRLPNLDNVHIIGHSLGAHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTDPI 239
            |.:|.:|..|:.. :.:|||:||||||:|::|.||..|:...|    ||||||||.|.|......
Mouse   161 AFLVQVLSTEMGY-SPENVHLIGHSLGSHVAGEAGRRLEGHVG----RITGLDPAEPCFQGLPEE 220

  Fly   240 VRLDKTDAHFVDIVHTDANPLMKG-GLGINMRLGHVDFFPNGGFDNPGCNKK-FQDVVKKKTLFL 302
            ||||.:||.|||::|||:.|::.. |.|::.::||:|||||||.:.|||.|. ...:|....::.
Mouse   221 VRLDPSDAMFVDVIHTDSAPIIPYLGFGMSQKVGHLDFFPNGGKEMPGCQKNILSTIVDINGIWE 285

  Fly   303 TMQEFLGCNHIRSQQYFTESIGSQCPFLGITCDSFESFKDTKCTSCEEPGHTCLRMGYHSQEDYQ 367
            ..:.|..|||:||.:|:..||.:...|||..|.|:|.|:...|..|.|.|  |.:||:::.:...
Mouse   286 GTRNFAACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQHNDCFPCPEQG--CPKMGHYADQFEG 348

  Fly   368 EQVDLGQLQQGDSPGVFYLWTGDSKPFCRLHYRITVRVSG 407
            :...:.|        .|:|.||||..|.|..|:::|.:||
Mouse   349 KTATVEQ--------TFFLNTGDSGNFTRWRYKVSVTLSG 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5966	NP_572286.1	Lipase	46..394	CDD:278576	125/350 (36%)
CG5966	NP_572286.1	Pancreat_lipase_like	76..390	CDD:238363	112/315 (36%)
Pnliprp2	NP_035258.2	Lipase	31..367	CDD:278576	125/350 (36%)
		Pancreat_lipase_like	65..363	CDD:238363	112/315 (36%)
		Required for galactolipase activity. /evidence=ECO:0000250\|UniProtKB:P54317	106..118		4/11 (36%)
		Required for galactolipase activity. /evidence=ECO:0000250\|UniProtKB:P54317	270..292		3/21 (14%)
		PLAT_PL	370..482	CDD:238857	4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2419
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3275
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	1	1.000	-	-		FOG0001245
OrthoInspector	1	1.000	-	-		otm43283
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X699
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930