DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5966 and Lipc

DIOPT Version :9

Sequence 1:	NP_572286.1	Gene:	CG5966 / 31532	FlyBaseID:	FBgn0029831	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_006510879.1	Gene:	Lipc / 15450	MGIID:	96216	Length:	526	Species:	Mus musculus

Alignment Length:	507	Identity:	134/507 - (26%)
Similarity:	210/507 - (41%)	Gaps:	114/507 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 RALDQPK-----YLDLND----------PESVQGMGMNPKGKIFLLVHGY--LESGEI------- 126
            :.|.:|:     :.|.||          ||::|..|.|....:.:::||:  .||..:
Mouse    42 KPLKKPETRFLLFQDENDRLGCRLRPQHPETLQECGFNSSQPLIMIIHGWSGSESATVGKDSDSD 106

  Fly   127 --------PWMWDMAKALLAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGAITAHVVHMLYE 183
                    .|:|.:..||.:.:.: ..:|.|:||...|...|..||.|.|:||...|.::..|.|
Mouse   107 YQVDGLLENWIWKIVSALKSRQSQ-PVNVGLVDWISLAYQHYTIAVQNTRIVGQDVAALLLWLEE 170

  Fly   184 ELRLPNLDNVHIIGHSLGAHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTDPIVRLDKTDAH 248
            ..:. :...||:||:|||||:||:||..:  |...|..||||||||.|:|..|.|..||...||:
Mouse   171 SAKF-SRSKVHLIGYSLGAHVSGFAGSSM--DGKNKIGRITGLDPAGPMFEGTSPNERLSPDDAN 232

  Fly   249 FVDIVHTDANPLMKGGLGINMRLGHVDFFPNGGFDNPGCN--KKFQDVVKKKTLFLTMQEFLGCN 311
            |||.:||.....|...:||...:.|.||:||||...|||:  :.::.:.:.....:|  :.:.|.
Mouse   233 FVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAIT--QTIKCA 295

  Fly   312 HIRSQQYFTESI-GSQCPFLGITCDSFESFKDTKCTSCEEPGHTCLRMGYHSQEDYQEQVDLGQL 375
            |.||...|.:|: .|....:|..|....||....|.||::  ..|..:||..::|
Mouse   296 HERSVHLFIDSLQHSDLQSIGFQCSDMGSFSQGLCLSCKK--GRCNTLGYDIRKD---------- 348

  Fly   376 QQGDSPGVFYLWTGDSKPFCRLHYRITVRVSGHDES--------TLHG--GEVGILSIQLHDALV 430
            :.|.|..:| |.|....||...||:..::.....|.        :|.|  .|:..:.|.|.:.:.
Mouse   349 RSGKSKRLF-LITRAQSPFKVYHYQFKIQFINQIEKPVEPTFTMSLLGTKEEIKRIPITLGEGIT 412

  Fly   431 KKAGKNERAATEMMKFSQKAMYFEPGYEYKALVAGRNLREPEYATVNWEYPTNILNPLTWRILSA 495
                            |.|...|       .:...:::.|.......||      |...|
Mouse   413 ----------------SNKTYSF-------LITLDKDIGELILLKFKWE------NSAVW----- 443

  Fly   496 PRIY--LEYILIEAMESSDLYLKLCPQHEGAIL-----TGAENVLRSSYCKD 540
            ..::  ::.|::..:|         |.|.|.||     ...|...|.::|.:
Mouse   444 ANVWNTVQTIMLWGIE---------PHHSGLILKTIWVKAGETQQRMTFCPE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5966	NP_572286.1	Lipase	46..394	CDD:278576	106/342 (31%)
CG5966	NP_572286.1	Pancreat_lipase_like	76..390	CDD:238363	106/338 (31%)
Lipc	XP_006510879.1	Lipase	18..366	CDD:333880	106/342 (31%)
Lipc	XP_006510879.1	PLAT_LPL	369..504	CDD:238856	26/161 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920