DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6048 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_572282.1	Gene:	CG6048 / 31528	FlyBaseID:	FBgn0029827	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	257	Identity:	95/257 - (36%)
Similarity:	136/257 - (52%)	Gaps:	39/257 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 RIINGTEASLGATRHQVGIRKALNDGYFFGTGHLCGGSLIRPGWVLTAAHCFVDQIIYDGTFVPK 109
            ||:.||.:|.|....|..::        ....|:|||:||...||:||||||.:    |....||
Mouse   576 RIVGGTVSSEGEWPWQASLQ--------IRGRHICGGALIADRWVITAAHCFQE----DSMASPK 628

  Fly   110 EEFIVVMGNLDRYNR-TNTLTFTIEERIMQLDKFDLSTYDKDIALLMLNGTVPTGHP-----TIR 168
             .:.|.:|.:.:.:| ...::|.: .|:......:..::|.|:|||.|:      ||     |:|
Mouse   629 -LWTVFLGKMRQNSRWPGEVSFKV-SRLFLHPYHEEDSHDYDVALLQLD------HPVVYSATVR 685

  Fly   169 PIAL---NRFAIPEGVVCQVTGWG-NTEDGYVSDILMTVDVPMISEEHCINDSDLGHLIQPGMIC 229
            |:.|   :.|..| |..|.:|||| ..|.|.||:.|..|||.::.::.|  .....:.:.|.|:|
Mouse   686 PVCLPARSHFFEP-GQHCWITGWGAQREGGPVSNTLQKVDVQLVPQDLC--SEAYRYQVSPRMLC 747

  Fly   230 AGYLEVGEKDACAGDSGGPLVCQSE-----LAGVVSWGIQCALPRLPGVYTEVSYYYDWILQ 286
            |||.: |:||||.|||||||||:..     |||:||||:.|..|...||||.|:...:||.|
Mouse   748 AGYRK-GKKDACQGDSGGPLVCREPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVINWIQQ 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	92/253 (36%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	92/253 (36%)
		Tryp_SPc	577..809	CDD:238113	94/256 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920