DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6048 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_572282.1	Gene:	CG6048 / 31528	FlyBaseID:	FBgn0029827	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	251	Identity:	90/251 - (35%)
Similarity:	124/251 - (49%)	Gaps:	36/251 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 RIINGTEASLGATRHQVGIRKALNDGYFFGTGHLCGGSLIRPGWVLTAAHCFVDQIIYDGTFVPK 109
            |::...|||:.:...||.|:        :...|:||||::.|.|||||||||..   :...|..|
Human   204 RVVGVEEASVDSWPWQVSIQ--------YDKQHVCGGSILDPHWVLTAAHCFRK---HTDVFNWK 257

  Fly   110 EEFIVVMGNLDRYNRTNTLTFTIEERIMQLDKFDLSTYDKDIALLMLNGTVPTGHPTIRPIALNR 174
                 |....|:.....:|...   :|:.::...:...|.||||:.|...: |...|:|||.|..
Human   258 -----VRAGSDKLGSFPSLAVA---KIIIIEFNPMYPKDNDIALMKLQFPL-TFSGTVRPICLPF 313

  Fly   175 F------AIPEGVVCQVTGWGNTED--GYVSDILMTVDVPMISEEHCINDSDLGHLIQPGMICAG 231
            |      |.|..::    |||.|:.  |.:||||:...|.:|....|..|......:...|:|||
Human   314 FDEELTPATPLWII----GWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAG 374

  Fly   232 YLEVGEKDACAGDSGGPLVCQSE---LAGVVSWGIQCALPRLPGVYTEVSYYYDWI 284
            ..| |..|.|.|||||||:.||:   :.|:||||..|..|..|||||:||.|.:||
Human   375 IPE-GGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	88/249 (35%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335
		Tryp_SPc	204..429	CDD:214473	88/249 (35%)
		Tryp_SPc	205..432	CDD:238113	89/250 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910