DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6048 and PRSS53

DIOPT Version :9

Sequence 1:	NP_572282.1	Gene:	CG6048 / 31528	FlyBaseID:	FBgn0029827	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	312	Identity:	86/312 - (27%)
Similarity:	123/312 - (39%)	Gaps:	87/312 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 HLCGGSLIRPGWVLTAAHCFVDQIIYDGTFVPKEEFIVVMGNLDRYNRTNTLTFTIEE---RIMQ 138
            |:|.|||:...|||||||||     ..........:.||:|:|.|    ..|:...||   ..:|
Human    60 HICSGSLVADTWVLTAAHCF-----EKAAATELNSWSVVLGSLQR----EGLSPGAEEVGVAALQ 115

  Fly   139 LDK-FDLSTYDKDIALLMLNGTVPTGH-PTIRPIALNRFAIPEGVVCQVTGWG-NTEDG------ 194
            |.: ::..:...|:|||.|  ..||.| |...|...:||  |.|..|..|||. :|.||
Human   116 LPRAYNHYSQGSDLALLQL--AHPTTHTPLCLPQPAHRF--PFGASCWATGWDQDTSDGKCWPRL 176

  Fly   195 YVSDIL----MTVDVP-----------------------------------MISEEHC------I 214
            .:.:.|    :||..|                                   :||...|      :
Human   177 KLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQL 241

  Fly   215 NDSDLGHLIQPGMICAGYLEVGEKDACAGDSGGPLVCQSE-----LAGVVSWGIQCALPRLPGVY 274
            :...|.:..:|||:|.| .:.|.:..|.||||||::|...     .||::|:...||....|.:.
Human   242 HQRHLSNPARPGMLCGG-PQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLL 305

  Fly   275 TEVSYYYDWI---------LQNMGENGEGSGEES--GEGSGEGSGEGSGEGS 315
            |..:.:..|:         |....|..|.|.|:|  ..||...:|..:|..|
Human   306 TNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPS 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	74/268 (28%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	75/269 (28%)
		Tryp_SPc	43..314	CDD:214473	74/267 (28%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920