DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6048 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_572282.1	Gene:	CG6048 / 31528	FlyBaseID:	FBgn0029827	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	302	Identity:	91/302 - (30%)
Similarity:	140/302 - (46%)	Gaps:	66/302 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RGATTRTHLDTKAIRPRFNADPGRIINGTEASLGATRHQVGIRKALNDGYFFGTGHLCGGSLIRP 86
            |..:...|.|.....|     ..||:.|..:|.|....|..::        ....|:|||:||..
Human   549 RDGSDEEHCDCGLQGP-----SSRIVGGAVSSEGEWPWQASLQ--------VRGRHICGGALIAD 600

  Fly    87 GWVLTAAHCFVDQIIYDGTFVPKEEFIVVMGNLDRYNR-TNTLTFTIEERIMQLDKFDLSTYDKD 150
            .||:||||||.:..:.....     :.|.:|.:.:.:| ...::|.: .|::.....:..::|.|
Human   601 RWVITAAHCFQEDSMASTVL-----WTVFLGKVWQNSRWPGEVSFKV-SRLLLHPYHEEDSHDYD 659

  Fly   151 IALLMLNGTVPTGHPTIRPIALNRFAIP-------EGVVCQVTGWGNTEDGY------------- 195
            :|||.|:      ||.:|..|:....:|       .|:.|.:||||...:|.
Human   660 VALLQLD------HPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGALRADAVALFYGWR 718

  Fly   196 ----------VSDILMTVDVPMISEEHCINDSDL-GHLIQPGMICAGYLEVGEKDACAGDSGGPL 249
                      :|:.|..|||.:|.::.|   |:: .:.:.|.|:||||.: |:||||.|||||||
Human   719 NQGSETCCCPISNALQKVDVQLIPQDLC---SEVYRYQVTPRMLCAGYRK-GKKDACQGDSGGPL 779

  Fly   250 VCQS-----ELAGVVSWGIQCALPRLPGVYTEVSYYYDWILQ 286
            ||::     .|||:||||:.|..|...||||.::....||.|
Human   780 VCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQ 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	84/275 (31%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486	1/7 (14%)
		Tryp_SPc	568..822	CDD:238113	86/278 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920