DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6048 and PRSS36

DIOPT Version :9

Sequence 1:	NP_572282.1	Gene:	CG6048 / 31528	FlyBaseID:	FBgn0029827	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	326	Identity:	106/326 - (32%)
Similarity:	147/326 - (45%)	Gaps:	67/326 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLAVALLLI------FLPSGLRGATTRTHLDTKAIRPRFNADPGRIINGTEASLGATRHQVGIRK 65
            ||.:.:|:|      |..|.| ..|.....|....||..:|   ||:.|:.|..|....||.:.
Human     6 LLPLVMLVISPIPGAFQDSAL-SPTQEEPEDLDCGRPEPSA---RIVGGSNAQPGTWPWQVSLH- 65

  Fly    66 ALNDGYFFGTGHLCGGSLIRPGWVLTAAHCFVDQIIYDGTFVPKEEFIVVM------GNLDRYNR 124
                   .|.||:||||||.|.|||:|||||:.    :||..|..|:.|::      |.||..:.
Human    66 -------HGGGHICGGSLIAPSWVLSAAHCFMT----NGTLEPAAEWSVLLGVHSQDGPLDGAHT 119

  Fly   125 TNTLTFTIEERIMQLDKFDLSTYDKDIALLMLNGTVPTGHPTIRPIAL----NRFAIPEGVVCQV 185
            .......:.....|::      ...|:|||.|......| |.:.|:.|    :||.  .|..|..
Human   120 RAVAAIVVPANYSQVE------LGADLALLRLASPASLG-PAVWPVCLPRASHRFV--HGTACWA 175

  Fly   186 TGWGNTEDGYVSD------ILMTVDVPMISEEHC------INDSDLGHLIQPGMICAGYLEVGEK 238
            ||||:.::   :|      :|..|::.::.|..|      ....:|...|.|||:||||.| |.:
Human   176 TGWGDVQE---ADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPE-GRR 236

  Fly   239 DACAGDSGGPLVCQSE----LAGVVSWGIQCALPRLPGVYTEVSYYYDWILQNMGENGEGSGEES 299
            |.|.|||||||||:..    .||:.|:|..|.....|||:|.|:.|..||.:.:      .|.|.
Human   237 DTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQV------MGSEP 295

  Fly   300 G 300
            |
Human   296 G 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	89/264 (34%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	89/264 (34%)
		Tryp_SPc	47..289	CDD:238113	90/266 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316		3/5 (60%)
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920