DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6048 and tmprss6

DIOPT Version :9

Sequence 1:	NP_572282.1	Gene:	CG6048 / 31528	FlyBaseID:	FBgn0029827	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	251	Identity:	90/251 - (35%)
Similarity:	141/251 - (56%)	Gaps:	30/251 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 RIINGTEASLGATRHQVGIRKALNDGYFFGTGHLCGGSLIRPGWVLTAAHCFVDQIIYDGTFVPK 109
            |::.||:|..|....|..::        ....|:|||:|:...|:|||||||..:     ::...
Frog   570 RLVGGTQAQEGEWPWQASLQ--------VRGEHICGGTLVADQWILTAAHCFTPE-----SYASP 621

  Fly   110 EEFIVVMGNLDRYNRT--NTLTFTIEERIMQLDKFDLSTYDKDIALLMLNGTVPTGHPTIRPIAL 172
            |.:.|.:|.: |.:|:  ..|.|.: .|::....:|..::|.|:||::|:..||...|.::||.|
Frog   622 EVWTVYLGKV-RLSRSTQKELAFKV-IRLVIHPFYDEDSHDYDVALVLLDHLVPLTSPHVQPICL 684

  Fly   173 --NRFAIPEGVVCQVTGWGNT-EDGYVSDILMTVDVPMISEEHCINDSDL-GHLIQPGMICAGYL 233
              :....|.|..|.|||||:. |:|..||:|..||:.:::::.|   ::| .:.|.|.|:||||.
Frog   685 PSSTHHFPTGSSCWVTGWGSVKENGPTSDVLQKVDIQLVAQDIC---TELYRYQISPRMLCAGYR 746

  Fly   234 EVGEKDACAGDSGGPLVCQSE-----LAGVVSWGIQCALPRLPGVYTEVSYYYDWI 284
            : |.||||.||||.||||::.     .||:||||..|.:||..|||:.::....||
Frog   747 D-GSKDACQGDSGSPLVCKTASGRWFQAGLVSWGAGCGIPRYFGVYSRITRLVQWI 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6048	NP_572282.1	Tryp_SPc	45..284	CDD:214473	88/249 (35%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060
		Tryp_SPc	572..804	CDD:238113	89/249 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920