DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6041 and PRSS1

DIOPT Version :9

Sequence 1:	NP_572281.1	Gene:	CG6041 / 31527	FlyBaseID:	FBgn0029826	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	253	Identity:	93/253 - (36%)
Similarity:	128/253 - (50%)	Gaps:	41/253 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EPKIVGGYDASIEQVSYQVSIRLTANDKKSYGSG-HLCGGVVISQRLVATAAHCCYITDKKKYRT 95
            :.||||||:.....|.||||:          .|| |.|||.:|:::.|.:|.||        |::
Human   246 DDKIVGGYNCEENSVPYQVSL----------NSGYHFCGGSLINEQWVVSAGHC--------YKS 292

  Fly    96 -----AGEF---VLVMGSTYLTSSTDRTLMYYLQQLITHENYNPDALTNDIALMFINGYIPWNWP 152
                 .||.   ||.....::.::          ::|.|..|:...|.|||.|:.::.....| .
Human   293 RIQVRLGEHNIEVLEGNEQFINAA----------KIIRHPQYDRKTLNNDIMLIKLSSRAVIN-A 346

  Fly   153 TVTALALNSQLVATNTDCLISGWGLLQQNGTFSSNTLQAATVPIVSYTTCRISY-NSIPVSQVCA 216
            .|:.::|.:...||.|.|||||||....:|....:.||....|::|...|..|| ..|..:..|.
Human   347 RVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCV 411

  Fly   217 GYLSGGVDACQGDSGGPMSCNGMLAGIVSYGAGCAAPGYPGVYTNVSYYYDWIVQKNS 274
            |:|.||.|:||||||||:.|||.|.|:||:|.|||....|||||.|..|..||  ||:
Human   412 GFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWI--KNT 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6041	NP_572281.1	Tryp_SPc	34..269	CDD:214473	89/244 (36%)
CG6041	NP_572281.1	Tryp_SPc	35..272	CDD:238113	90/246 (37%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	89/244 (36%)
		Tryp_SPc	249..467	CDD:238113	91/248 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920