DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3726 and KLHL12

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_011508137.1	Gene:	KLHL12 / 59349	HGNCID:	19360	Length:	623	Species:	Homo sapiens

Alignment Length:	216	Identity:	52/216 - (24%)
Similarity:	97/216 - (44%)	Gaps:	21/216 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASER-DPIIIMKDV 76
            |..::....:.|......|||||..|.:...|||:||.|||.:|.|:.::..||: .|.:.::.:
Human    70 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGL 134

  Fly    77 TFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPP----------- 130
            |.:.::.|::|:|...::|...::..||..|..|::||:.:......|....|.
Human   135 TASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAET 199

  Fly   131 ------MAAAEFHSPPRSLAESYAQDLILQHQQQQQQGPAAPPLNLHSSAALLER--DRERERER 187
                  |.|||..|..........::.||..|.:.::......:.:.|...:.|.  :..:..::
Human   200 HNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKK 264

  Fly   188 DRERLSPGMEGVLGRMPVMTP 208
            :||...|.:...: |||::||
Human   265 EREESLPNLLQYV-RMPLLTP 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	31/97 (32%)
		BTB	32..121	CDD:197585	29/89 (33%)
		HTH_psq	587..622	CDD:283007
KLHL12	XP_011508137.1	BTB	78..181	CDD:279045	31/102 (30%)
		PHA03098	101..556	CDD:222983	44/185 (24%)
		BACK	190..291	CDD:285009	18/96 (19%)
		KELCH repeat	329..370	CDD:276965
		Kelch	337..384	CDD:128874
		KELCH repeat	374..420	CDD:276965
		Kelch	385..434	CDD:128874
		KELCH repeat	424..467	CDD:276965
		Kelch	436..481	CDD:128874
		KELCH repeat	471..514	CDD:276965
		Kelch	482..528	CDD:128874
		KELCH repeat	518..562	CDD:276965
		Kelch	529..575	CDD:128874
		KELCH repeat	565..610	CDD:276965
		Kelch	576..620	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910