DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3726 and AgaP_AGAP000585

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_001688288.2	Gene:	AgaP_AGAP000585 / 5666833	VectorBaseID:	AGAP000585	Length:	1296	Species:	Anopheles gambiae

Alignment Length:	729	Identity:	182/729 - (24%)
Similarity:	246/729 - (33%)	Gaps:	270/729 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YCLRWKYHHSNLQTMFSQLLDRGCFCDVTLAC-EGQLIRAHRVVLCACSTFFDAVLSNYASERDP 69
            |||||..|.|||..:|||||......|||||| ||..||||:|||.|||::|..:..::.: |.|
Mosquito     6 YCLRWNNHQSNLLGVFSQLLQDESLVDVTLACSEGASIRAHKVVLSACSSYFQTLFLDHPA-RHP 69

  Fly    70 IIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPPMAAA 134
            |:|:|||.|||::.|||||||||:|||:..|.:|||||..||:|||.|:|
Mosquito    70 IVILKDVRFAELRTLIEFMYKGEVNVEYCQLSALLKTAKSLKVKGLTEMT--------------- 119

  Fly   135 EFHSPPRSLAESYAQDLILQHQQQQQQGPAAPPLNLHSSAALLERDRERERERDRERLSPGMEGV 199
                                    .|..|...|              :.|.||.|...|.|..|.
Mosquito   120 ------------------------NQSSPLTEP--------------KLEPERLRPHSSHGAGGG 146

  Fly   200 LGRMPVMTPLTGASGSAGVGSVSGGTSL---EGVAPVE----------------HFLGPKRKRGR 245
            :          ||:|.:..||.||||:|   |.:.|..                .:|........
Mosquito   147 V----------GATGGSNSGSGSGGTTLAASEAILPTNLSTTLPTATLAGGGGGPYLTSTTTTAT 201

  Fly   246 PPLDDAYDVFNVRKLAQYAANLEPAQRAYLETARHFTEEPPLAAHAASMASPPAACPPKQRQRLR 310
            |.....    .|...|..|..  ...|:...|....|.||       ..|..|||...:|:...:
Mosquito   202 PGAAST----TVSTTATTATT--TGSRSSTTTTTTTTSEP-------DGADRPAAAEQQQQHHQQ 253

  Fly   311 HQQQ-----QQQQL---------------LQSESSDQEQPAAGQDWSNLEPNGSATPKLLSDGDA 355
            |.||     |||:|               |.|.||.....|...:.::|.........::.:.||
Mosquito   254 HSQQHHYTTQQQRLSSSGIGSASVTSASSLSSSSSSSSSTATAGNVTDLSTTHGKDAAMVCEADA 318

  Fly   356 NKQETEGGDESLP----------------AVLTTASSSGTKKLEKIGER---------------- 388
            :.........:..                |..|||.||.:........|
Mosquito   319 STAAAPSATTTTTPLSLLTRKHRDAPIDIATATTALSSASAAAVTSSARTAARWWRWCLAAAAAP 383

  Fly   389 -------RERHGK----------------LRHARRLYEKSGEDEVDPP---KEEPDELPQPVEEI 427
                   |...|.                .|.|..|::       :||   :|||:|:.|   |:
Mosquito   384 PPPTVIQRPASGDGILSSQLAASAVSSDGRRSATPLHD-------EPPSREEEEPEEMEQ---EV 438

  Fly   428 ENEHLVANRAESPRPTVVIPASFACKYEGGVTAA------------------GGGSGSGTGSGSL 474
            .:.|     .:..|.|..|.|:...:.:...||.                  ..|:..||.|...
Mosquito   439 NDRH-----PQDARTTPTIGAALDDERDTTTTATTTTTTVSDKADAHQSAHQERGARIGTASPPA 498

  Fly   475 GS-------------------------------------SYLINEHGMLMAH---EFAPNVASAA 499
            ||                                     :.||.:..:..:.   |....|...|
Mosquito   499 GSGGDTDECAASDEPAAAGDPVTACCSTSIAERQPSPAPAALIPDSSLSRSSPLGELVDEVRRPA 563

  Fly   500 ATAAVAVAAAAAAVANASAGNGNGG-------QDVSGSGTGAAADYPDIKLE-----------DY 546
            ::||.|.||||||...|:....:..       :||    |...|||.|.:.|           |.
Mosquito   564 SSAAAAAAAAAAAALMATDLRTDTDHHHAMLLRDV----TMGTADYDDEEEEEEEDEDEGEDVDD 624

  Fly   547 DAAELRLTNEELSQ 560
            .|||:.|....::|
Mosquito   625 GAAEMLLAAAAVAQ 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	57/97 (59%)
		BTB	32..121	CDD:197585	54/89 (61%)
		HTH_psq	587..622	CDD:283007
AgaP_AGAP000585	XP_001688288.2	BTB	21..118	CDD:279045	57/97 (59%)
		BTB	32..118	CDD:197585	52/86 (60%)
		C2H2 Zn finger	1197..1217	CDD:275368
		zf-H2C2_2	1209..1233	CDD:290200
		C2H2 Zn finger	1225..1245	CDD:275368
		zf-H2C2_2	1237..1262	CDD:290200
		C2H2 Zn finger	1253..1273	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23110
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100