DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3726 and mod(mdg4)

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_788698.1	Gene:	mod(mdg4) / 49228	FlyBaseID:	FBgn0002781	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	133/540 - (24%)
Similarity:	210/540 - (38%)	Gaps:	169/540 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QQYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASERD 68
            :|:.|.|...::||...|.:.|.||...||:||.|||:::|||:||..||.||..:.:...|...
  Fly     5 EQFSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTH 69

  Fly    69 PIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPPMAA 133
            .|:.:.:|:.:.:|.||:|||.||:||:..:||:.:.||:.|:||||.     |::..|.||..:
  Fly    70 AIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLT-----DNDPAPQPPQES 129

  Fly   134 AEFHSPPRSLAESYAQDLILQHQQQQQ----------------------------QGPAAPPLNL 170
                |||.:......|.:..|..|:||                            |..|||
  Fly   130 ----SPPPAAPHVQQQQIPAQRVQRQQPRASARYKIETVDDGLGDEKQSTTQIVIQTTAAP---- 186

  Fly   171 HSSAALLERDRERE--RERDRERLSPG------MEGVLGRMPVMTPLTGASGSAGVGSVSGGTSL 227
              .|.::::.:.::  ::...::|..|      :.....|....:.||.||.||||......||.
  Fly   187 --QATIVQQQQPQQAAQQIQSQQLQTGTTTTATLVSTNKRSAQRSSLTPASSSAGVKRSKTSTSA 249

  Fly   228 EGVAPVEHFLGPKRKRGRPPLDDAYDVFNVRKLAQYAANLEPAQRAYLETARHFTEEPPLAAHAA 292
            ..:               .|||...:..     |...|.|.| |:..::|
  Fly   250 NVM---------------DPLDSTTETG-----ATTTAQLVP-QQITVQT--------------- 278

  Fly   293 SMASPPAACPPKQRQRLRHQQQQQQQLLQSESS----DQEQPAAGQ-DWSNLEPNGSATPKLLSD 352
            |:.|...|         :..||..||:.|.|:.    ..|.|...: |:|  |.:|.|.
  Fly   279 SVVSAAEA---------KLHQQSPQQVRQEEAEYIDLPMELPTKSEPDYS--EDHGDAA------ 326

  Fly   353 GDAN----KQETEGG---DESL------PAVLTTASSSG---TKKLEKIGERRERHGKLRHARRL 401
            |||.    :.:|.|.   |:|.      ....|.|::||   |....|...:::...
  Fly   327 GDAEGTYVEDDTYGDMRYDDSYFTENEDAGNQTAANTSGGGVTATTSKAVVKQQSQN-------- 383

  Fly   402 YEKS---------GEDEVD----------PPKEE-------PDELPQP--VEEIENEHLVANRAE 438
            |.:|         |..|..          ||::.       .|:.|:|  :|:::...|....:|
  Fly   384 YSESSFVDTSGDQGNTEAQAATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLNEEASE 448

  Fly   439 SPRPTVVIPASFACKYEGGV 458
                    ||.:|...:|||
  Fly   449 --------PAVYASTTKGGV 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	42/96 (44%)
		BTB	32..121	CDD:197585	38/88 (43%)
		HTH_psq	587..622	CDD:283007
mod(mdg4)	NP_788698.1	BTB	22..118	CDD:279045	42/100 (42%)
		BTB	33..118	CDD:197585	38/89 (43%)
		FLYWCH	452..512	CDD:282369	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010