DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3726 and KLHL17

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_006710663.1	Gene:	KLHL17 / 339451	HGNCID:	24023	Length:	665	Species:	Homo sapiens

Alignment Length:	668	Identity:	132/668 - (19%)
Similarity:	206/668 - (30%)	Gaps:	269/668 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASE-RDPIIIMK 74
            |.|:.:.....|::..||..||:.|....:.||||:|||.:||.:|.|:.:|..|| |...:.:.
Human    72 KRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLH 136

  Fly    75 DVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPPMAAAEFHSP 139
            |:....:..|::|.|..||.|...::.:||..|..|::.|:     ||         |..:|
Human   137 DIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGV-----RD---------ACCKF--- 184

  Fly   140 PRSLAESYAQDLILQHQQQQQQGPAAPPLNLHSSAALLERDRERERERDRERLSPGMEGVLGRMP 204
                                                ||            .:|.|
Human   185 ------------------------------------LL------------SQLDP---------- 191

  Fly   205 VMTPLTGASGSAGVGSVSGGTSLEGVAPVEHFLGPKRKRGRPPLDDAYDVFNVRKLAQYAANLEP 269
                             |....:.|.|                  ||:...::         |:.
Human   192 -----------------SNCLGIRGFA------------------DAHSCSDL---------LKA 212

  Fly   270 AQRAYLETARHF-----TEEPPLAAHAASMASPPAACPPKQRQRLRHQQQQQQQLLQSES----S 325
            |.|..|:   ||     |||..|.....:.:..|.:..|....|......|..:|:.|:|    |
Human   213 AHRYVLQ---HFVDVAKTEEFMLLPLKQASSGLPGSTGPSPDLRSEDPHSQVLELVSSDSLNVPS 274

  Fly   326 DQEQPAAGQDWSNLEPNGSATPKLLSDGDANKQETEGGDESLPAVLTTASSSGTKKLEKIGERRE 390
            ::|...|...|            :..|.||.:|.       :|.::...      :|..:    .
Human   275 EEEVYRAVLSW------------VKHDVDARRQH-------VPRLMKCV------RLPLL----S 310

  Fly   391 RHGKLRHARRLYEKSGEDEVDPPKEEPDELPQPVEEI------ENEHLVANRAESPRPTVVIPAS 449
            |...|.|.         |.....:..||.....:|.:      |...::......||
Human   311 RDFLLGHV---------DAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPR-------- 358

  Fly   450 FACKYEGGVTAAGGGSGSGTGSGSLGSSYLINEHGMLMAHEFAP---NVASAAATAAVAVAAAAA 511
             .|:..|.|..|.||          ||.:.|  ||...|::...   :|.::.:|....|..||.
Human   359 -RCEGAGPVLFAVGG----------GSLFAI--HGDCEAYDTRTDRWHVVASMSTRRARVGVAAV 410

  Fly   512 AVANASAGNGNGGQDVSGSGTGAAADYPDIKLEDYDAAELRLTNEELSQWQDVIKMDDYLAKGRR 576
            .....:.|..:|..|::             .:|.||.    :||    .||..:.|.
Human   411 GNRLYAVGGYDGTSDLA-------------TVESYDP----VTN----TWQPEVSMG-------- 446

  Fly   577 PQFWEEPFTKRVLDAIKNKRLEMKKAARILGVS--YGTLY--GRYREVYGCLK-----HPYSGTA 632
                    |:|                ..|||:  :|.||  |.| :...||.     .|.:||
Human   447 --------TRR----------------SCLGVAALHGLLYSAGGY-DGASCLNSAERYDPLTGT- 485

  Fly   633 FRNSGSTSTSQMGVQPRF 650
                 .||.:.|..:.|:
Human   486 -----WTSVAAMSTRRRY 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	33/97 (34%)
		BTB	32..121	CDD:197585	29/89 (33%)
		HTH_psq	587..622	CDD:283007	9/38 (24%)
KLHL17	XP_006710663.1	BTB	82..186	CDD:279045	37/156 (24%)
		PHA03098	92..581	CDD:222983	127/648 (20%)
		BACK	194..318	CDD:285009	33/182 (18%)
		Kelch	366..412	CDD:128874	15/57 (26%)
		Kelch_1	401..446	CDD:279660	13/65 (20%)
		KELCH repeat	402..445	CDD:276965	13/63 (21%)
		KELCH repeat	449..492	CDD:276965	16/65 (25%)
		Kelch	460..506	CDD:128874	13/46 (28%)
		KELCH repeat	496..540	CDD:276965	1/3 (33%)
		Kelch	508..553	CDD:128874
		KELCH repeat	543..587	CDD:276965
		Kelch	555..600	CDD:128874
		KELCH repeat	590..635	CDD:276965
		Kelch	602..646	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910