DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3726 and chinmo

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	164/764 - (21%)
Similarity:	244/764 - (31%)	Gaps:	274/764 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QQYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASERD 68
            ||:||:|....|||...||.|.......||.|:|:|.:.:||:::|.|||..|..:..|..:...
  Fly     5 QQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQ 69

  Fly    69 PIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPPMAA 133
            .:||::..|...:..|:|||||||::|...:|.|.||:|:.|::|||:..|.|         :||
  Fly    70 CVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGR---------LAA 125

  Fly   134 AEFHSPPRSLAESYAQDLILQHQQQQQQGPAAPPLNLHSSAALLERDRERERERDRERLS----- 193
                                 .|.||..|..:|            .|....|...|..||
  Fly   126 ---------------------QQAQQHMGDLSP------------LDSPTGRRSVRNSLSGGSSS 157

  Fly   194 --PGMEGV------------------------------------------LGRMPVMTPLTGASG 214
              ||..|:                                          |..:.....:....|
  Fly   158 IVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAGGGMAAAANAAASSLSTLAASANIVDRCG 222

  Fly   215 SAGV-----------GSVSGGT------------------------SLEGVAPVEHFLGPKRKRG 244
            |||.           ||.|||.                        ||...|...|.||     |
  Fly   223 SAGANIISGSAAGIGGSHSGGAGNGSGTVGIGGNGVGSGGGNNGPISLGSGAGAAHHLG-----G 282

  Fly   245 RPPLDDAYDVFNVRKLAQYAANLEPAQRAYLETARHFTEEPPLAAHAASMASPPAACPPKQRQRL 309
            ...:           |.|...:|.....:...:...:|..||:       ..|....||::|..:
  Fly   283 STGI-----------LKQECDSLMHPGGSSSSSGMGYTHVPPI-------YRPINYEPPRKRAIV 329

  Fly   310 R---HQQQQQQQLLQSESSDQEQPAAGQDWSNLEPNGSATPKLLSDGDANKQETEGGDES----- 366
            |   .:|:|:..:|:..|...|.|:.........|:.||:....::.|....|......|
  Fly   330 RSPYSEQEQRGSVLRDGSKSSECPSPINKPPYHRPSSSASSTAPTEADTMHSERASPQSSRYENH 394

  Fly   367 LPAVLTTASSSGTKKLEKIGERRERHGKLRHA----RRLYEKSGEDEVD--------------PP 413
            .|:. |..:.:.|..||:|.:....:|....|    |.|.::|.::..:              ||
  Fly   395 SPST-TAGNGNATSSLERIVKSERNNGSANEANDDDRELMDESTDNGAEDLRVKLENLKYSPPPP 458

  Fly   414 KEEPDELPQPVEEIEN----EHLVANRAESPRPTVVIPASFACKY--EGGVTAAGGGS------- 465
            .........|...:||    ..|.:|.|.|..|..::....|.|.  :..|..|.|..
  Fly   459 PNSNTSSTTPNTLLENLKADGTLSSNLAASIAPADMLNVWNATKMNNKNSVNTADGKKLKCLYCD 523

  Fly   466 ---GSGTG------------------------SGSLGSSYLINEH----GMLM------AHEFAP 493
               |..|.                        ..:....::..||    |:..      ||..|.
  Fly   524 RLYGYETNLRAHIRQRHQGIRVPCPFCERTFTRNNTVRRHIAREHKQEIGLAAGATIAPAHLAAA 588

  Fly   494 NVASAAATAA--------VAVAAAAAAVANAS--------------------------------- 517
            ..||||||||        .|..|||:.|.||:
  Fly   589 AAASAAATAAASNHSPXEAAATAAASVVMNANKEAAKQRKRKTLKMALEKCMQRRDAMVAETTTG 653

  Fly   518 AG------NGNGGQDVSGSGTGAAADYPDIKLEDYDAAELRLTNEELSQ 560
            ||      .|..|:.|.|:|:...|.....:...|:..:.|: ::||:|
  Fly   654 AGGDGAEAGGESGEAVDGAGSEEGAGSEGTEPLTYEQQQQRM-HQELTQ 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	37/96 (39%)
		BTB	32..121	CDD:197585	35/88 (40%)
		HTH_psq	587..622	CDD:283007
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	35/93 (38%)
		BTB	33..116	CDD:197585	32/82 (39%)
		C2H2 Zn finger	519..540	CDD:275368	2/20 (10%)
		C2H2 Zn finger	547..568	CDD:275368	0/20 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020