DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3726 and CG12236

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	130/568 - (22%)
Similarity:	217/568 - (38%)	Gaps:	129/568 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QQYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASERD 68
            |||.|||..:..:|............|.||:|..:|:.|:||:|||.:||::|..:........
  Fly     5 QQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPH- 68

  Fly    69 PIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPPMAA 133
            |:||.|.:.|.::..:|||||:||:||:..:|.|.|:||:.|.::||.    .::::.|..|:|.
  Fly    69 PVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLT----AEEKEKPQIPVAP 129

  Fly   134 AEFHSPPRSLAESYAQDLILQHQQQQQQGPAAPPLNLHSSAALLERDRERERERDRERLSPGMEG 198
            .   .....|.::....:...::||||....|   ...::...:|
  Fly   130 L---ISEHKLIKTIPSTIRAVNEQQQQVSNVA---QAQTATQTIE-------------------- 168

  Fly   199 VLGRMPVMTPLTGASGSAGVGSVSGGTSLEGVA---PVEHFLGPKRKRGRPPLDDAYDVFNVRKL 260
                :|..|.|...:.|.....|....:....|   .|:|
  Fly   169 ----IPAATLLQATNASQVPSQVVAAAAAAAAAQQLQVQH------------------------- 204

  Fly   261 AQYAANLEPAQRAYLETARHFTEEPPLAAHAASMASPPAACPPKQRQRLRHQQQQQQQLLQSESS 325
                   :..|..:::|.:        ..|....::||.. ..:|:|:.:.|||||||..|.:.|
  Fly   205 -------QQQQHHHVQTTQ--------IQHIQVQSAPPPQ-QQQQQQQQQQQQQQQQQQQQQQQS 253

  Fly   326 DQEQPAAGQDWSNLEPNGSATPK---------LLSDGDANKQETEGGDESL---PAVLTTASSS- 377
            .|:|....|.......|..|.|.         ..||.|.|...||..|.::   ..::.||..:
  Fly   254 QQQQTTPVQTQHLTITNAVALPAASSVKKRKITFSDDDDNMYTTETVDYAVKDEQTIVKTAEMTF 318

  Fly   378 --GTKKLE----KIGERRER-----------HGKLRHARRLYEKSGEDEVDPPKEEPDELPQPVE 425
              |..|::    .:||..:|           ......|:.:.:.|.|.|:         |.:  .
  Fly   319 LRGAVKMDIPDYIVGEVDDRLSDGATPQTSQDATTAAAQNVAQYSSEYEI---------LTE--S 372

  Fly   426 EIENEHLVANRAESPRPTVVIPASFACKYEGGVTAAGGG---SGSGTGSGSLGSSYLINEHGMLM 487
            |:|.::    :|::....:.|..:.......|...||.|   ..||.||.:.|.|..::. ..:.
  Fly   373 EMEEKY----QADADNAEIAIEMTRLLGTASGTPGAGSGQVMEDSGGGSATTGPSTTVSV-TQVK 432

  Fly   488 AHEFAPNVASAAATAAVAVAAAAAAVANASAGNGNGGQDVSGSGTGAA 535
            :...|....:|....:|.||.::.:.|.|||... |..:.|...||.|
  Fly   433 SDSKASGTNAALKPGSVTVARSSKSGATASAPPA-GSDEESVQYTGLA 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	36/96 (38%)
		BTB	32..121	CDD:197585	35/88 (40%)
		HTH_psq	587..622	CDD:283007
CG12236	NP_727050.1	BTB	22..116	CDD:279045	35/94 (37%)
		BTB	33..116	CDD:197585	34/83 (41%)
		Herpes_capsid	<376..467	CDD:283714	21/96 (22%)
		C2H2 Zn finger	483..512	CDD:275371
		C2H2 Zn finger	514..535	CDD:275371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020