DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3726 and Zbtb20

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001099350.2	Gene:	Zbtb20 / 288105	RGDID:	1560387	Length:	741	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	145/735 - (19%)
Similarity:	247/735 - (33%)	Gaps:	189/735 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KYHHSNLQTMFSQLLD-------RGCFCDVTLACEGQLIRAHRVVLCACSTFF-DAVLSNYASER 67
            :.|..||....:.:|:       ||.|||||:...|.::||||.||.|.|.|| |.:|..|:...
  Rat    77 RIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIE 141

  Fly    68 DPIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWR----------- 121
            .|.:    |:...|:.||:|||.|.:.|..|....:|..|..|:||.:.:...|
  Rat   142 IPSV----VSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFP 202

  Fly   122 -------DDEDGPPPPMAAAEFHSPPRSLAESYAQDLI-----------LQHQQQQQQGPAAPPL 168
                   |...|.|....:.:.........:|:.|..:           :|:...::...:...:
  Rat   203 GIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVV 267

  Fly   169 NLHSSAALLERDRERER----ERDRERLSPGMEGVLGRMPVMTPLTGASGSAGVGSVSGGTSLEG 229
            :.|.:|..|.||...|.    .|..|| |..||..|...|..|..........:.::.|...:
  Rat   268 SHHETALGLPRDHHMEDPSWITRIHER-SQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHI-- 329

  Fly   230 VAPVEHFLGPKRKRGRPPLDDAYDVFNVRKLAQYAANLEPAQRAYLETARHFTEEPPLAAHAASM 294
                           :..::|.||.:..:::.....|.........:.|.....||...:..:.:
  Rat   330 ---------------KQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGV 379

  Fly   295 ASPPAACPPKQRQRLRHQQQQQQQLLQSESSDQEQPAAGQDWSNLEPN----GSATPKLLSDGDA 355
            :|.....|....|:......::.|:   |::..||.|.....|:.:||    |:::|:..::.:.
  Rat   380 SSSIGTEPDSVEQQFGAGATREGQV---EAAQPEQAAEAPAESSAQPNQLETGASSPERSTEVEM 441

  Fly   356 NKQETEGGDESLPAVLTTASSSGTKKLEK------IGERRERHGKLRHARRLYEKSGEDEVDPPK 414
            :.           .|:|.::||....|::      ||:...       :.:||.:..|...
  Rat   442 DN-----------TVITVSNSSDKGVLQQPSVNTSIGQPLP-------STQLYLRQTETLT---- 484

  Fly   415 EEPDELPQPVEEIENEHLVANRAESPRPTVVIPASFACKYEGGVTAAGGGSGSGTG--------S 471
               ..|..|:....|..::.....:     .:||.|        |....|||....        :
  Rat   485 ---SNLRMPLTLTSNTQVIGTAGNT-----YLPALF--------TTQPAGSGPKPFLFSLPQPLT 533

  Fly   472 GSLGSSYLINEHGMLMAHEFAPNVASAAATAAVAVAAAAAAVANASAGNGNGGQDVSGSGTGAAA 536
            |.......:::.|:            :..||.:......|:.|:.|..:|.|
  Rat   534 GQQTQFVTVSQPGL------------STFTAQLPAPQPLASSASHSTASGQG------------- 573

  Fly   537 DYPDIKLEDYDAAELRLTNEELSQWQDVIKMDDYLAKGRRPQ----FWEEPFTKRVL-------- 589
                    |....|..|.|:..:..|:.:| ..::..|.:|.    .|.....|..|
  Rat   574 --------DKKPYECTLCNKTFTAKQNYVK-HMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHT 629

  Fly   590 ------DAIKNKRLEMKKAARI-LGVSYGTLYGRYREVYGCLKHPYSGTAFR-----NSGSTSTS 642
                  .:|.|||...|.:..: :.:..|.   :..|.|.|.|.....|...     :|.|..|.
  Rat   630 GVRAYQCSICNKRFTQKSSLNVHMRLHRGE---KSYECYICKKKFSHKTLLERHVALHSASNGTP 691

  Fly   643 QMGVQPRFDLGFRNG--GVL 660
            ..|..|    |.|.|  ||:
  Rat   692 PAGTPP----GARAGPPGVV 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	38/104 (37%)
		BTB	32..121	CDD:197585	33/89 (37%)
		HTH_psq	587..622	CDD:283007	8/49 (16%)
Zbtb20	NP_001099350.2	BTB_POZ_ZBTB20_DPZF	79..195	CDD:349517	42/119 (35%)
		zf-C2H2	578..600	CDD:395048	5/22 (23%)
		C2H2 Zn finger	580..600	CDD:275368	4/20 (20%)
		SUF4-like	608..>657	CDD:411020	8/48 (17%)
		C2H2 Zn finger	608..629	CDD:411020	3/20 (15%)
		C2H2 Zn finger	608..628	CDD:275368	3/19 (16%)
		zf-C2H2	634..656	CDD:395048	5/21 (24%)
		C2H2 Zn finger	636..656	CDD:411020	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		zf-H2C2_2	648..673	CDD:404364	5/27 (19%)
		C2H2 Zn finger	664..684	CDD:275368	4/19 (21%)
		C2H2 Zn finger	717..737	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910