DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3726 and ZBTB9

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_689948.1	Gene:	ZBTB9 / 221504	HGNCID:	28323	Length:	473	Species:	Homo sapiens

Alignment Length:	433	Identity:	88/433 - (20%)
Similarity:	144/433 - (33%)	Gaps:	144/433 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQQYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFF-DAVLSNYASE 66
            |:...:.:..|.|:|....::....|.||||:|..:|:.:|||:.||.|.|.:| |.:|...|
Human    20 PRTIQIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDA-- 82

  Fly    67 RDPIIIMKDVTFAEV-KCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWR--------- 121
              |.:.:..|..|:. :.|::.:|.|.:.:...:||:.|..|..|::       |:
Human    83 --PRLTLPSVIEADAFEGLLQLIYSGRLRLPLDALPAHLLVASGLQM-------WQVVDQCSEIL 138

  Fly   122 ---DDEDGPPPPMAAAEFH----------------SPPRSLAESYAQDLILQHQQQQQQGPAAPP 167
               :...|.........:|                ||.::..:|.|          ..:.||:..
Human   139 RELETSGGGISARGGNSYHALLSTTSSTGGWCIRSSPFQTPVQSSA----------STESPASTE 193

  Fly   168 LNLHSSAALL--------ERDRERERERDRERLSPGMEGVLGRMPVMTPLTGASGSAGVGSVSGG 224
            ..:....:.|        |.:.|.|.:.|.|                     ..|||.:......
Human   194 SPVGGEGSELGEVLQIQVEEEEEEEEDDDDE---------------------DQGSATLSQTPQP 237

  Fly   225 TSLEGVAPVEHFLGPKRKRGRPPLDDAYDVFNVRKLAQYAANLEPAQRAYLETARHFTEEPPLAA 289
            ..:.||.|..|...|......|           |||.:                   .|..||
Human   238 QRVSGVFPRPHGPHPLPMTATP-----------RKLPE-------------------GESAPL-- 270

  Fly   290 HAASMASPPAACPPKQRQRLRHQQQQQQQLLQSESSDQEQPAAGQDWSNLEPNGS-ATPKLLSDG 353
               .:.:|| |.|||            ...::.|..:.::..:|   |..:|.|: ...|:.|.|
Human   271 ---ELPAPP-ALPPK------------IFYIKQEPFEPKEEISG---SGTQPGGAKEETKVFSGG 316

  Fly   354 DANKQETEGGDE---SLPAVLTTASSSGTKKLEKIGERRERHG 393
            |     |||..|   .||:.....|..|....:.:    :.||
Human   317 D-----TEGNGELGFLLPSGPGPTSGGGGPSWKPV----DLHG 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	29/98 (30%)
		BTB	32..121	CDD:197585	26/90 (29%)
		HTH_psq	587..622	CDD:283007
ZBTB9	NP_689948.1	BTB	38..140	CDD:306997	30/112 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..279		28/168 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..376		18/70 (26%)
		C2H2 Zn finger	388..405	CDD:275368
		C2H2 Zn finger	413..433	CDD:275368
		zf-C2H2	413..433	CDD:306579
		C2H2 Zn finger	440..457	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910