DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3726 and AgaP_AGAP003537

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_003436512.1	Gene:	AgaP_AGAP003537 / 1274194	VectorBaseID:	AGAP003537	Length:	885	Species:	Anopheles gambiae

Alignment Length:	748	Identity:	186/748 - (24%)
Similarity:	280/748 - (37%)	Gaps:	222/748 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPQQYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYAS 65
            |..|::||||..|.:||..:|.|||....|.|||||.|||.::||::||.|||.:|..:..:: .
Mosquito     1 MTSQRFCLRWNNHQTNLLAVFDQLLHDETFIDVTLAVEGQHLKAHKMVLSACSPYFQQLFVSH-P 64

  Fly    66 ERDPIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPP 130
            |:.||:|::||.|.::|||::|||:||::|:...|.:.|:.|:.|:||||.||  .||:...|..
Mosquito    65 EKHPIVILRDVPFKDMKCLLDFMYRGEVSVDQDRLAAFLRVAESLRIKGLTEV--NDDKPNAPSG 127

  Fly   131 MAAAEFHSPPRSLAESYAQDLILQHQQQQQQGPAAPPLNLHSSAALLERDRERERERDRERLSPG 195
            .|:|...:...|.|.|.||                                           :.|
Mosquito   128 SASATATNSAGSAASSGAQ-------------------------------------------ATG 149

  Fly   196 MEGVLGRMPVMTPLTGASGSAGVGSVSGGTSLEGVAPVEHFLGPKRKRGRPPLDDAYD----VFN 256
            .......:|..|....:|||:|:           ||.|:              ||..|    |.|
Mosquito   150 ATTTTNTVPNATVQKNSSGSSGM-----------VAQVD--------------DDEDDRCSPVPN 189

  Fly   257 VRKLAQYAANLEPAQRAYLETARHFTEEPPLAAHAASMASPPAACPPKQRQRLRHQQQQQQQLLQ 321
            ...:|..||:...||..:|:..      |||.:....:.                 :.....|||
Mosquito   190 SIAVAPNAASSGQAQGGHLKPL------PPLLSSTGIVT-----------------RSHSNSLLQ 231

  Fly   322 SESSD--------QEQPAAGQDWSNLEPNGSATPKLLSDGDANKQETEG---------GDE---- 365
            ...|.        |..|..|...|. :......|:.||..||.:.||||         |:|
Mosquito   232 QGGSSAASGSAMVQTNPLLGTALSQ-QKRKRGRPRKLSGSDAGEGETEGNFVGGGGAPGEEYDSS 295

  Fly   366 -----SLPAVLTTASSSG--TKKLEKIGERRERHGKLRHARRLYEKSGEDEVDPPKEEPDELPQP 423
                 .:....:.||:||  .::|..:..|.:....|.|.:.......:|||  ..:|.|||
Mosquito   296 SMDIMDVKIASSGASNSGDDDQQLRIVSSRTDDDDTLMHEKAEQLDDEDDEV--MDDEADEL--- 355

  Fly   424 VEEIENEHLVANRAESP------RPTVVIPASFACKYEGGVTAAGGGSGSGTGSGSLGSSYLINE 482
            |::::.|.....|..||      ..|:           |.:......:|:...||        .:
Mosquito   356 VDDVDLEAGDEPRGTSPSLDESMEDTI-----------GNMDGTTNNNGNTNRSG--------RQ 401

  Fly   483 HGMLMAHEFAPNVASAAATAAVAVAAAAAAVANASAGNGNGGQDVSGS-----------GTGAAA 536
            |             ....||  |...:.|:..:.:..|.|...|...|           ||||..
Mosquito   402 H-------------QKQGTA--AAKPSRASKRSRTRNNENSLSDSKDSFAEDDKCNKLDGTGAGE 451

  Fly   537 DYPDIKLEDYDAAELRLTNEELSQWQDVIKMDDYLAKGRRPQFWEEP----FTKR----VLDAIK 593
            :..||:.:.||..||   |..|.:.|  :.:|:|          :||    |..|    .:|:..
Mosquito   452 EEDDIEDDQYDGREL---NSSLMEPQ--LLLDEY----------DEPVEFKFDPRTDSGAVDSTS 501

  Fly   594 NKR----LEMKKAARILGVSYGTLYGRYREV-YGCLKHP------YSG---TAFRNSGSTSTSQM 644
            |..    |:.|...:|...|.|....:...| ...|:.|      .||   ::|...||.:.|.:
Mosquito   502 NSNYLPPLQPKPGLKIASTSGGARMPQISVVPTTALQIPKLAPLTASGGGTSSFLGGGSNNKSSV 566

  Fly   645 GVQPRFDL--GFRNGGVLPAQLELGKLKKDLSE 675
            .:..|..|  ..:..|:...|..|..|..:|:|
Mosquito   567 KLHKRARLMTPKKPNGMTTTQTILNNLNNNLNE 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	45/96 (47%)
		BTB	32..121	CDD:197585	42/88 (48%)
		HTH_psq	587..622	CDD:283007	9/43 (21%)
AgaP_AGAP003537	XP_003436512.1	BTB	21..117	CDD:279045	45/96 (47%)
		BTB	32..117	CDD:197585	40/85 (47%)
		C2H2 Zn finger	685..706	CDD:275370
		C2H2 Zn finger	715..734	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010