DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3726 and AgaP_AGAP010355

DIOPT Version :9

Sequence 1:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_311585.4	Gene:	AgaP_AGAP010355 / 1272684	VectorBaseID:	AGAP010355	Length:	874	Species:	Anopheles gambiae

Alignment Length:	853	Identity:	167/853 - (19%)
Similarity:	260/853 - (30%)	Gaps:	311/853 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LPQQ--YCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYA 64
            :|.|  |.|||..|.:::...|..||......||||.|....||||:|||.|||.||..|.|:..
Mosquito     1 MPDQEHYSLRWNNHQNHILRAFDTLLQTKTLVDVTLVCAETSIRAHKVVLSACSPFFQRVFSDTP 65

  Fly    65 SERDPIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPP 129
            . :.|:|::||.....|:.:::|||:|||:|....|..|::..:.|:::||.:           .
Mosquito    66 C-KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQERLSVLIQAGESLQVRGLVD-----------H 118

  Fly   130 PMAAAEFHSPPRSLAESYAQDLILQHQQQQQQGPAAPPLNL---HSSAALLERDRERERERDRER 191
            |:||   ::|  :.|||.....:|:........|:.|..|.   |.|..|      |........
Mosquito   119 PVAA---NTP--TPAESPEDFSLLEGSLISPTSPSLPSPNFQTNHQSGQL------RHHSTTPSS 172

  Fly   192 LSPGMEGVLGRMPVMTPLTGASGSAGVGSVSGGTSLEGVAPVEHFLG--PKRKRGRP-------- 246
            |..|....|    ::.|...|..|..:.|          |||:....  |:||:.||
Mosquito   173 LISGNASKL----LLPPQVFADPSINLPS----------APVDTCTSPMPRRKQARPRRRSGDCG 223

  Fly   247 ----------PL-----------------------------DDAYDVFNV--------RKLAQYA 264
                      |:                             ||..|:..:        .|||...
Mosquito   224 PQDLSSKPSTPVPQTLDDDETERDLLDERPDDEDELEDLEDDDDEDLKRILHRSQSVDEKLAALV 288

  Fly   265 AN---------------------------------LEPAQRAYLETARHFTEEPPLAAH--AASM 294
            ||                                 |.|.:.....::.....:..|...  |.|.
Mosquito   289 ANENLRTHSSNSLTTTPTTTNPTSNDERRSRSLHKLSPRKTPSANSSAELLRDVDLETDPVAVSS 353

  Fly   295 ASPPAACPPKQRQRLRHQQQQQQQLLQSESSDQEQPAAGQDWSNLEPNGSATPKLLSDGDANKQE 359
            ||||.:..|             :.|...:||.....|...|       ||.....||||.:.:..
Mosquito   354 ASPPVSDGP-------------ENLCMKKSSSSNGTARMSD-------GSKESSSLSDGISGQLS 398

  Fly   360 TEG-------------------GDESLPAVLTTASSSGTKKLEKIGERRERHGKLRHARRLYEKS 405
            ..|                   |..|.|..|::.|::....|..:......|.....::|:..:.
Mosquito   399 KRGLLSLKDIRHLNRAALNRSLGSISPPPSLSSLSNNLHPALSLMHHHHHHHHHHGESKRVKLED 463

  Fly   406 GEDEVDPPKEEPDELPQPVEEIE---------------NEHLVANRAESPRPTVVIPASFACKYE 455
            .|||.....::..|.|..::.::               ::|.:.|.:...||.:|         :
Mosquito   464 REDERSLLHDDMMEPPHFLDHMDLALSTHQHPLAHHLAHQHHLRNSSPHVRPPMV---------D 519

  Fly   456 GGVTAAGGG--SGSGTGSGSLGSSYLINEHGMLMAHEFAPNVASAAATAAVAVAAAAAAVANASA 518
            .|:...|..  :.||..|.:...|...|.|.                           ::.|...
Mosquito   520 AGIDNNGSNKQNNSGILSNNNNDSAGTNNHN---------------------------SILNQLH 557

  Fly   519 GNGNGGQDVSGSGTGAAADY---PDIKLEDY---------------------DAAELRLTNEEL- 558
            .|.|..........|...|:   |.:....:                     ..:.|.||...:
Mosquito   558 SNPNNKHHHQSGSAGGPKDFLHSPTLNFPPFFNHAEGPPRPTHSPLPFPHMPSVSSLTLTPPHMF 622

  Fly   559 ----------------SQWQDVIKMDD----------YLAK-------------GRRPQFWEEPF 584
                            ..:..:::|.|          :|.|             |..|:.|....
Mosquito   623 GLDSPLGLFPPGMDPGKIYSPLMEMSDPRGLHHEGPPFLKKKMNRPKGQHSAPRGGPPRSWTNAE 687

  Fly   585 TKRVLDAIKNKRLEMKKAARILGVSYGTLYGRYREVYG-----------CLKHPYSGTAFRNSGS 638
            ....|..:.||::...:|:||.|:.|.:|....|..||           |:..|          .
Mosquito   688 LTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGP----------P 742

  Fly   639 TSTSQMGV 646
            ....||||
Mosquito   743 IELLQMGV 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	39/96 (41%)
		BTB	32..121	CDD:197585	36/88 (41%)
		HTH_psq	587..622	CDD:283007	10/34 (29%)
AgaP_AGAP010355	XP_311585.4	BTB	22..118	CDD:279045	39/107 (36%)
		BTB	33..118	CDD:197585	36/96 (38%)
		HTH_psq	684..727	CDD:283007	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920